FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1976714996> ?p ?o ?g. }

• W1976714996 endingPage "156" @default.
• W1976714996 startingPage "147" @default.
• W1976714996 abstract "Bursts of nascent mRNA have been shown to lead to substantial cell-cell variation in unicellular organisms, facilitating diverse responses to environmental challenges. It is unknown whether similar bursts and gene-expression noise occur in mammalian tissues. To address this, we combine single molecule transcript counting with dual-color labeling and quantification of nascent mRNA to characterize promoter states, transcription rates, and transcript lifetimes in the intact mouse liver. We find that liver gene expression is highly bursty, with promoters stochastically switching between transcriptionally active and inactive states. Promoters of genes with short mRNA lifetimes are active longer, facilitating rapid response while reducing burst-associated noise. Moreover, polyploid hepatocytes exhibit less noise than diploid hepatocytes, suggesting a possible benefit to liver polyploidy. Thus, temporal averaging and liver polyploidy dampen the intrinsic variability associated with transcriptional bursts. Our approach can be used to study transcriptional bursting in diverse mammalian tissues." @default.
• W1976714996 created "2016-06-24" @default.
• W1976714996 creator A5012843541 @default.
• W1976714996 creator A5013073728 @default.
• W1976714996 creator A5015479543 @default.
• W1976714996 creator A5042875880 @default.
• W1976714996 creator A5043816772 @default.
• W1976714996 creator A5067119906 @default.
• W1976714996 creator A5072218894 @default.
• W1976714996 creator A5073778618 @default.
• W1976714996 date "2015-04-01" @default.
• W1976714996 modified "2023-10-10" @default.
• W1976714996 title "Bursty Gene Expression in the Intact Mammalian Liver" @default.
• W1976714996 cites W168063310 @default.
• W1976714996 cites W1964259728 @default.
• W1976714996 cites W1971248187 @default.
• W1976714996 cites W1979302584 @default.
• W1976714996 cites W1984916226 @default.
• W1976714996 cites W1992927069 @default.
• W1976714996 cites W1993009001 @default.
• W1976714996 cites W1997179616 @default.
• W1976714996 cites W2003470745 @default.
• W1976714996 cites W2005806876 @default.
• W1976714996 cites W2009096224 @default.
• W1976714996 cites W2011172223 @default.
• W1976714996 cites W2017886758 @default.
• W1976714996 cites W2019472515 @default.
• W1976714996 cites W2021963778 @default.
• W1976714996 cites W2030086669 @default.
• W1976714996 cites W2031402631 @default.
• W1976714996 cites W2037768790 @default.
• W1976714996 cites W2043875880 @default.
• W1976714996 cites W2053460598 @default.
• W1976714996 cites W2061717797 @default.
• W1976714996 cites W2065923714 @default.
• W1976714996 cites W2067432938 @default.
• W1976714996 cites W2068978083 @default.
• W1976714996 cites W2070498223 @default.
• W1976714996 cites W2071411183 @default.
• W1976714996 cites W2075865654 @default.
• W1976714996 cites W2077046573 @default.
• W1976714996 cites W2080252570 @default.
• W1976714996 cites W2085319408 @default.
• W1976714996 cites W2091198609 @default.
• W1976714996 cites W2105512180 @default.
• W1976714996 cites W2105598902 @default.
• W1976714996 cites W2114870653 @default.
• W1976714996 cites W2115368299 @default.
• W1976714996 cites W2127013070 @default.
• W1976714996 cites W2128459167 @default.
• W1976714996 cites W2128551987 @default.
• W1976714996 cites W2128942354 @default.
• W1976714996 cites W2131925550 @default.
• W1976714996 cites W2134150890 @default.
• W1976714996 cites W2141688036 @default.
• W1976714996 cites W2149242848 @default.
• W1976714996 cites W2164721923 @default.
• W1976714996 cites W2167244112 @default.
• W1976714996 cites W2171280873 @default.
• W1976714996 cites W2171327609 @default.
• W1976714996 cites W2173366817 @default.
• W1976714996 cites W4256266823 @default.
• W1976714996 doi "https://doi.org/10.1016/j.molcel.2015.01.027" @default.
• W1976714996 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4500162" @default.
• W1976714996 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25728770" @default.
• W1976714996 hasPublicationYear "2015" @default.
• W1976714996 type Work @default.
• W1976714996 sameAs 1976714996 @default.
• W1976714996 citedByCount "223" @default.
• W1976714996 countsByYear W19767149962015 @default.
• W1976714996 countsByYear W19767149962016 @default.
• W1976714996 countsByYear W19767149962017 @default.
• W1976714996 countsByYear W19767149962018 @default.
• W1976714996 countsByYear W19767149962019 @default.
• W1976714996 countsByYear W19767149962020 @default.
• W1976714996 countsByYear W19767149962021 @default.
• W1976714996 countsByYear W19767149962022 @default.
• W1976714996 countsByYear W19767149962023 @default.
• W1976714996 crossrefType "journal-article" @default.
• W1976714996 hasAuthorship W1976714996A5012843541 @default.
• W1976714996 hasAuthorship W1976714996A5013073728 @default.
• W1976714996 hasAuthorship W1976714996A5015479543 @default.
• W1976714996 hasAuthorship W1976714996A5042875880 @default.
• W1976714996 hasAuthorship W1976714996A5043816772 @default.
• W1976714996 hasAuthorship W1976714996A5067119906 @default.
• W1976714996 hasAuthorship W1976714996A5072218894 @default.
• W1976714996 hasAuthorship W1976714996A5073778618 @default.
• W1976714996 hasBestOaLocation W19767149961 @default.
• W1976714996 hasConcept C101762097 @default.
• W1976714996 hasConcept C104317684 @default.
• W1976714996 hasConcept C105580179 @default.
• W1976714996 hasConcept C138885662 @default.
• W1976714996 hasConcept C150194340 @default.
• W1976714996 hasConcept C165864922 @default.
• W1976714996 hasConcept C179926584 @default.
• W1976714996 hasConcept C41895202 @default.
• W1976714996 hasConcept C54355233 @default.
• W1976714996 hasConcept C86803240 @default.

• next