FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1976716335> ?p ?o ?g. }

• W1976716335 endingPage "641" @default.
• W1976716335 startingPage "631" @default.
• W1976716335 abstract "Physiological functions of mitochondria in contractile arterial myocytes are poorly understood. Mitochondria can uptake calcium (Ca(2+)), but intracellular Ca(2+) signals that regulate mitochondrial Ca(2+) concentration ([Ca(2+)](mito)) and physiological functions of changes in [Ca(2+)](mito) in arterial myocytes are unclear.To identify Ca(2+) signals that regulate [Ca(2+)](mito), examine the significance of changes in [Ca(2+)](mito), and test the hypothesis that [Ca(2+)](mito) controls functional ion channel transcription in myocytes of resistance-size cerebral arteries.Endothelin (ET)-1 activated Ca(2+) waves and elevated global Ca(2+) concentration ([Ca(2+)](i)) via inositol 1,4,5-trisphosphate receptor (IP(3)R) activation. IP(3)R-mediated sarcoplasmic reticulum (SR) Ca(2+) release increased [Ca(2+)](mito) and induced mitochondrial depolarization, which stimulated mitochondrial reactive oxygen species (mitoROS) generation that elevated cytosolic ROS. In contrast, a global [Ca(2+)](i) elevation did not alter [Ca(2+)](mito), mitochondrial potential, or mitoROS generation. ET-1 stimulated nuclear translocation of nuclear factor (NF)-kappaB p50 subunit and ET-1-induced IP(3)R-mediated mitoROS elevated NF-kappaB-dependent transcriptional activity. ET-1 elevated voltage-dependent Ca(2+) (Ca(V)1.2) channel expression, leading to an increase in both pressure (myogenic tone)- and depolarization-induced vasoconstriction. Baseline Ca(V)1.2 expression and the ET-1-induced elevation in Ca(V)1.2 expression were both reduced by IP(3)R inhibition, mitochondrial electron transport chain block, antioxidant treatment, and NF-kappaB subunit knockdown, leading to vasodilation.IP(3)R-mediated SR Ca(2+) release elevates [Ca(2+)](mito), which induces mitoROS generation. MitoROS activate NF-kappaB, which stimulates Ca(V)1.2 channel transcription. Thus, mitochondria sense IP(3)R-mediated SR Ca(2+) release to control NF-kappaB-dependent Ca(V)1.2 channel expression in arterial myocytes, thereby modulating arterial contractility." @default.
• W1976716335 created "2016-06-24" @default.
• W1976716335 creator A5018134952 @default.
• W1976716335 creator A5022290210 @default.
• W1976716335 creator A5060315433 @default.
• W1976716335 creator A5076720785 @default.
• W1976716335 date "2010-09-03" @default.
• W1976716335 modified "2023-10-16" @default.
• W1976716335 title "Mitochondria Control Functional Ca _V 1.2 Expression in Smooth Muscle Cells of Cerebral Arteries" @default.
• W1976716335 cites W1485627882 @default.
• W1976716335 cites W150246076 @default.
• W1976716335 cites W1507213876 @default.
• W1976716335 cites W1585781020 @default.
• W1976716335 cites W1884656506 @default.
• W1976716335 cites W1913671643 @default.
• W1976716335 cites W1920479129 @default.
• W1976716335 cites W1967291007 @default.
• W1976716335 cites W1976136773 @default.
• W1976716335 cites W1976527906 @default.
• W1976716335 cites W1977448609 @default.
• W1976716335 cites W1978348074 @default.
• W1976716335 cites W1992032501 @default.
• W1976716335 cites W1993039541 @default.
• W1976716335 cites W2018682013 @default.
• W1976716335 cites W2021296052 @default.
• W1976716335 cites W2025319034 @default.
• W1976716335 cites W2038419938 @default.
• W1976716335 cites W2040599577 @default.
• W1976716335 cites W2068048197 @default.
• W1976716335 cites W2068821413 @default.
• W1976716335 cites W2071035461 @default.
• W1976716335 cites W2075700543 @default.
• W1976716335 cites W2084238143 @default.
• W1976716335 cites W2087398506 @default.
• W1976716335 cites W2088919308 @default.
• W1976716335 cites W2089781939 @default.
• W1976716335 cites W2090425674 @default.
• W1976716335 cites W2100663877 @default.
• W1976716335 cites W2107639321 @default.
• W1976716335 cites W2108435189 @default.
• W1976716335 cites W2112645157 @default.
• W1976716335 cites W2120618720 @default.
• W1976716335 cites W2121158779 @default.
• W1976716335 cites W2137640531 @default.
• W1976716335 cites W2141403366 @default.
• W1976716335 cites W2146886609 @default.
• W1976716335 cites W2154035441 @default.
• W1976716335 cites W2163272120 @default.
• W1976716335 cites W2164497329 @default.
• W1976716335 cites W2166518194 @default.
• W1976716335 cites W2170772130 @default.
• W1976716335 cites W2474296480 @default.
• W1976716335 doi "https://doi.org/10.1161/circresaha.110.224345" @default.
• W1976716335 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3050675" @default.
• W1976716335 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20616314" @default.
• W1976716335 hasPublicationYear "2010" @default.
• W1976716335 type Work @default.
• W1976716335 sameAs 1976716335 @default.
• W1976716335 citedByCount "61" @default.
• W1976716335 countsByYear W19767163352012 @default.
• W1976716335 countsByYear W19767163352013 @default.
• W1976716335 countsByYear W19767163352014 @default.
• W1976716335 countsByYear W19767163352015 @default.
• W1976716335 countsByYear W19767163352016 @default.
• W1976716335 countsByYear W19767163352017 @default.
• W1976716335 countsByYear W19767163352018 @default.
• W1976716335 countsByYear W19767163352019 @default.
• W1976716335 countsByYear W19767163352020 @default.
• W1976716335 countsByYear W19767163352021 @default.
• W1976716335 countsByYear W19767163352022 @default.
• W1976716335 countsByYear W19767163352023 @default.
• W1976716335 crossrefType "journal-article" @default.
• W1976716335 hasAuthorship W1976716335A5018134952 @default.
• W1976716335 hasAuthorship W1976716335A5022290210 @default.
• W1976716335 hasAuthorship W1976716335A5060315433 @default.
• W1976716335 hasAuthorship W1976716335A5076720785 @default.
• W1976716335 hasBestOaLocation W19767163351 @default.
• W1976716335 hasConcept C126322002 @default.
• W1976716335 hasConcept C134018914 @default.
• W1976716335 hasConcept C185592680 @default.
• W1976716335 hasConcept C207200792 @default.
• W1976716335 hasConcept C28859421 @default.
• W1976716335 hasConcept C4141045 @default.
• W1976716335 hasConcept C71924100 @default.
• W1976716335 hasConcept C86803240 @default.
• W1976716335 hasConcept C95444343 @default.
• W1976716335 hasConceptScore W1976716335C126322002 @default.
• W1976716335 hasConceptScore W1976716335C134018914 @default.
• W1976716335 hasConceptScore W1976716335C185592680 @default.
• W1976716335 hasConceptScore W1976716335C207200792 @default.
• W1976716335 hasConceptScore W1976716335C28859421 @default.
• W1976716335 hasConceptScore W1976716335C4141045 @default.
• W1976716335 hasConceptScore W1976716335C71924100 @default.
• W1976716335 hasConceptScore W1976716335C86803240 @default.
• W1976716335 hasConceptScore W1976716335C95444343 @default.
• W1976716335 hasIssue "5" @default.
• W1976716335 hasLocation W19767163351 @default.
• W1976716335 hasLocation W19767163352 @default.

• next