FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1976727846> ?p ?o ?g. }

• W1976727846 endingPage "113" @default.
• W1976727846 startingPage "103" @default.
• W1976727846 abstract "Activating cells of the immune system may stimulate human immunodeficiency virus type 1 (HIV-1) replication and contribute to select pathogenic variants in vivo. Here, we examined the possible effect of a major pathway of immune activation, CD40 interaction with its ligand (CD40L), on the susceptibility of monocyte-derived macrophages (MDMs) to various HIV-1 strains. Stimulation of MDMs with CD40L led to reduced replication of R5 HIV-1(Ba-L), whereas this strongly enhanced the replication of X4 HIV-1(Lai) as well as of X4 primary isolates, and this was associated with strong cytopathic effects. The replication of X4 strains was inhibited by stromal cell-derived factor 1, an indication of the restricted usage of CXCR4 as virus coreceptor in this case. CD40L induced the activation of mitogen-activated protein kinases ERK1/ERK2 and stimulated MDMs to secrete RANTES (regulated on activation, normal T cell expressed and secreted), macrophage inflammatory protein 1alpha (MIP-1alpha), MIP-1beta, interleukin 6 (IL-6), IL-1beta, and tumor necrosis factor alpha. From this data, it may be hypothesized that activated macrophages represent a favorable environment for the replication of classically T lymphocyte-tropic X4 variants and, thus, may contribute significantly to the selection of such variants at late stages of clinical HIV-1 infection." @default.
• W1976727846 created "2016-06-24" @default.
• W1976727846 creator A5021622956 @default.
• W1976727846 creator A5055539504 @default.
• W1976727846 creator A5057775882 @default.
• W1976727846 creator A5067641091 @default.
• W1976727846 creator A5073739175 @default.
• W1976727846 creator A5080268881 @default.
• W1976727846 date "2002-01-20" @default.
• W1976727846 modified "2023-10-18" @default.
• W1976727846 title "CD40-Activated Macrophages Become Highly Susceptible to X4 Strains of Human Immunodeficiency Virus Type 1" @default.
• W1976727846 cites W1490928025 @default.
• W1976727846 cites W1573821584 @default.
• W1976727846 cites W1830857550 @default.
• W1976727846 cites W1840516913 @default.
• W1976727846 cites W1850629568 @default.
• W1976727846 cites W1885192584 @default.
• W1976727846 cites W1970524401 @default.
• W1976727846 cites W1974616856 @default.
• W1976727846 cites W1981258449 @default.
• W1976727846 cites W1981684603 @default.
• W1976727846 cites W1984235828 @default.
• W1976727846 cites W2004319639 @default.
• W1976727846 cites W2019899829 @default.
• W1976727846 cites W2020751019 @default.
• W1976727846 cites W2028002620 @default.
• W1976727846 cites W2030017358 @default.
• W1976727846 cites W2030106757 @default.
• W1976727846 cites W2030844138 @default.
• W1976727846 cites W2032918869 @default.
• W1976727846 cites W2036890038 @default.
• W1976727846 cites W2043541788 @default.
• W1976727846 cites W2050937329 @default.
• W1976727846 cites W2052806033 @default.
• W1976727846 cites W2059417911 @default.
• W1976727846 cites W2060829964 @default.
• W1976727846 cites W2073013917 @default.
• W1976727846 cites W2075916954 @default.
• W1976727846 cites W2078930757 @default.
• W1976727846 cites W2084072841 @default.
• W1976727846 cites W2085464725 @default.
• W1976727846 cites W2089242226 @default.
• W1976727846 cites W2093410626 @default.
• W1976727846 cites W2097183306 @default.
• W1976727846 cites W2101492664 @default.
• W1976727846 cites W2102780335 @default.
• W1976727846 cites W2106804406 @default.
• W1976727846 cites W2116014786 @default.
• W1976727846 cites W2125442707 @default.
• W1976727846 cites W2141608261 @default.
• W1976727846 cites W2155070282 @default.
• W1976727846 cites W2155229523 @default.
• W1976727846 cites W2158752186 @default.
• W1976727846 cites W2159610080 @default.
• W1976727846 cites W2410629586 @default.
• W1976727846 cites W2415234673 @default.
• W1976727846 cites W4292820908 @default.
• W1976727846 cites W45806187 @default.
• W1976727846 doi "https://doi.org/10.1089/08892220252779647" @default.
• W1976727846 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11839143" @default.
• W1976727846 hasPublicationYear "2002" @default.
• W1976727846 type Work @default.
• W1976727846 sameAs 1976727846 @default.
• W1976727846 citedByCount "14" @default.
• W1976727846 countsByYear W19767278462012 @default.
• W1976727846 countsByYear W19767278462014 @default.
• W1976727846 countsByYear W19767278462019 @default.
• W1976727846 crossrefType "journal-article" @default.
• W1976727846 hasAuthorship W1976727846A5021622956 @default.
• W1976727846 hasAuthorship W1976727846A5055539504 @default.
• W1976727846 hasAuthorship W1976727846A5057775882 @default.
• W1976727846 hasAuthorship W1976727846A5067641091 @default.
• W1976727846 hasAuthorship W1976727846A5073739175 @default.
• W1976727846 hasAuthorship W1976727846A5080268881 @default.
• W1976727846 hasConcept C13373296 @default.
• W1976727846 hasConcept C140704245 @default.
• W1976727846 hasConcept C154317977 @default.
• W1976727846 hasConcept C159047783 @default.
• W1976727846 hasConcept C170217031 @default.
• W1976727846 hasConcept C17991360 @default.
• W1976727846 hasConcept C202751555 @default.
• W1976727846 hasConcept C203014093 @default.
• W1976727846 hasConcept C2522874641 @default.
• W1976727846 hasConcept C2779244956 @default.
• W1976727846 hasConcept C2781184567 @default.
• W1976727846 hasConcept C39347974 @default.
• W1976727846 hasConcept C55493867 @default.
• W1976727846 hasConcept C86803240 @default.
• W1976727846 hasConcept C8891405 @default.
• W1976727846 hasConceptScore W1976727846C13373296 @default.
• W1976727846 hasConceptScore W1976727846C140704245 @default.
• W1976727846 hasConceptScore W1976727846C154317977 @default.
• W1976727846 hasConceptScore W1976727846C159047783 @default.
• W1976727846 hasConceptScore W1976727846C170217031 @default.
• W1976727846 hasConceptScore W1976727846C17991360 @default.
• W1976727846 hasConceptScore W1976727846C202751555 @default.
• W1976727846 hasConceptScore W1976727846C203014093 @default.
• W1976727846 hasConceptScore W1976727846C2522874641 @default.

• next