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• W1976731460 abstract "The population structure of seven rural communities from the island of Krk (Croatia) was studied on the basis of its genetic constitution and genetic structure, and different sets of biological (genetic), biocultural (migration), cultural (linguistic), and geographic data. Genetic constitution was estimated from the allelic frequencies of nine tetranucleotide STR loci, three HLA class I loci, five HLA class II loci, and five red blood cell enzyme and serum protein loci. Genetic structure was based on coefficients of genetic diversity G(ST) and genetic kinship R(ST). Population structure was assessed by the structure of mutual relationships among biological, biocultural, cultural, and geographic matrices through Mantel's test, or by relationships among biological, biocultural, cultural measures of distance and/or similarity, and geographic distance with regression analysis of the isolation by distance model. One group of genetic markers (red blood enzymes, serum proteins, and HLA polymorphisms) reflects heterogeneity of the rural communities (a reflection of important historical processes and migration patterns), and a second group of genetic markers (STR polymorphisms) reflects the currently observed genetic homogeneity of the rural population. The positive correlations between the matrices of genetic (HLA) and linguistic distances indicate their possible co-evolution under conditions of genetic isolation (low gene flow). Furthermore, the negative correlations between the matrices of genetic (STR) distances and the migration kinship of the second and the third cohort indicate temporal coincidence between genetic constitution and structure assessed from STRs and migration patterns in the period between 1892 and 1940. Finally, the positive correlations between the matrices of genetic (STR) and geographic distances indicate isolation by distance. Am. J. Hum. Biol. 12:509-525, 2000. Copyright 2000 Wiley-Liss, Inc." @default.
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• W1976731460 date "2000-01-01" @default.
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• W1976731460 title "Population structure of the rural communities on the island of Krk (Croatia): A comparison of genetic, cultural, and geographic data" @default.
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• W1976731460 doi "https://doi.org/10.1002/1520-6300(200007/08)12:4<509::aid-ajhb11>3.0.co;2-x" @default.
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