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• W1976745102 abstract "Amlodipine is a potent vasodilator with a long half-life and delayed onset of action that is particularly concerning after an overdose. Vasodilation occurs through stimulation of nitric oxide release with increased cyclic guanosine monophosphate (cGMP) production. Methylene blue inhibits guanylate cyclase. This enzyme is responsible for the production of cGMP. Methylene blue also has the ability to scavenge nitric oxide, as well as inhibit nitric oxide synthase. We report the use of methylene blue for refractory shock in a patient with amlodipine toxicity." @default.
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• W1976745102 date "2011-12-01" @default.
• W1976745102 modified "2023-09-25" @default.
• W1976745102 title "Methylene Blue in the Treatment of Refractory Shock From an Amlodipine Overdose" @default.
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• W1976745102 doi "https://doi.org/10.1016/j.annemergmed.2011.02.025" @default.
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