FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1976756918> ?p ?o ?g. }

• W1976756918 endingPage "2295" @default.
• W1976756918 startingPage "2288" @default.
• W1976756918 abstract "Differentiation therapy may provide an alternative for treatment of cancers that do not respond to cytotoxic chemotherapy or hormonal manipulations. This hypothesis led us to evaluate the effect of a nontoxic differentiation inducer, sodium phenylacetate (NaPA), on hormone-refractory prostate cancer, the second most common cause of cancer deaths in men. NaPA treatment of androgen-independent PC3 and DU145 prostate cell lines, like that of hormone-responsive LNCaP cultures, resulted in dose-dependent inhibition of cell proliferation. Similar treatments were not significantly inhibitory to replicating normal endothelial cells and skin fibroblasts. In addition to the selective cytostatic effect, NaPA induced reversion of the prostatic cells to a nonmalignant phenotype, evidenced by their reduced invasiveness and loss of tumorigenicity in athymic mice. Phenotypic reversion was accompanied by alterations in gene expression, including selective reduction in tumor growth factor-beta 2 mRNA levels and increased amounts of class I major histocompatibility complex HLA transcripts. Furthermore, there was a decrease in tumor-associated proteolysis mediated by urokinase plasminogen activator, a molecular marker of disease progression in humans. When tumor cells were treated with NaPA together with suramin, a drug with demonstrable activity in patients, there was complete abrogation of cell growth under conditions in which each treatment alone produced only a partial effect. The in vitro antineoplastic activity was observed with drug concentrations that have been achieved in humans with no significant toxicities, suggesting that PA, used alone or in combination with other antitumor agents, warrants evaluation in the treatment of advanced prostatic cancer." @default.
• W1976756918 created "2016-06-24" @default.
• W1976756918 creator A5021149113 @default.
• W1976756918 creator A5065139905 @default.
• W1976756918 creator A5075895200 @default.
• W1976756918 date "1993-05-01" @default.
• W1976756918 modified "2023-10-03" @default.
• W1976756918 title "Selective growth arrest and phenotypic reversion of prostate cancer cells in vitro by nontoxic pharmacological concentrations of phenylacetate." @default.
• W1976756918 cites W1480410640 @default.
• W1976756918 cites W1496899148 @default.
• W1976756918 cites W1502033771 @default.
• W1976756918 cites W1505374702 @default.
• W1976756918 cites W1521160613 @default.
• W1976756918 cites W1551346835 @default.
• W1976756918 cites W1589574688 @default.
• W1976756918 cites W1729458249 @default.
• W1976756918 cites W1767142804 @default.
• W1976756918 cites W1938617858 @default.
• W1976756918 cites W1943056815 @default.
• W1976756918 cites W1969482311 @default.
• W1976756918 cites W1989081914 @default.
• W1976756918 cites W1991908530 @default.
• W1976756918 cites W1998467476 @default.
• W1976756918 cites W2014239161 @default.
• W1976756918 cites W2015852625 @default.
• W1976756918 cites W2030156015 @default.
• W1976756918 cites W2032484868 @default.
• W1976756918 cites W2049732521 @default.
• W1976756918 cites W2050687675 @default.
• W1976756918 cites W2054045654 @default.
• W1976756918 cites W2088612988 @default.
• W1976756918 cites W2101281838 @default.
• W1976756918 cites W2137330819 @default.
• W1976756918 cites W2140117937 @default.
• W1976756918 cites W2144125159 @default.
• W1976756918 cites W2149637946 @default.
• W1976756918 cites W2157803226 @default.
• W1976756918 cites W2168476587 @default.
• W1976756918 cites W2170420619 @default.
• W1976756918 cites W2204115562 @default.
• W1976756918 cites W2271098438 @default.
• W1976756918 cites W2331882414 @default.
• W1976756918 cites W2341981318 @default.
• W1976756918 cites W2395111376 @default.
• W1976756918 cites W2398661098 @default.
• W1976756918 cites W2401281430 @default.
• W1976756918 cites W2409673936 @default.
• W1976756918 cites W2410783083 @default.
• W1976756918 cites W2410788613 @default.
• W1976756918 cites W2411775406 @default.
• W1976756918 cites W2415099587 @default.
• W1976756918 cites W2417303506 @default.
• W1976756918 cites W2421330132 @default.
• W1976756918 cites W2443673815 @default.
• W1976756918 cites W2444070421 @default.
• W1976756918 cites W2484287653 @default.
• W1976756918 cites W31359041 @default.
• W1976756918 cites W60483430 @default.
• W1976756918 doi "https://doi.org/10.1172/jci116457" @default.
• W1976756918 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/288233" @default.
• W1976756918 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8486788" @default.
• W1976756918 hasPublicationYear "1993" @default.
• W1976756918 type Work @default.
• W1976756918 sameAs 1976756918 @default.
• W1976756918 citedByCount "128" @default.
• W1976756918 countsByYear W19767569182012 @default.
• W1976756918 countsByYear W19767569182013 @default.
• W1976756918 countsByYear W19767569182014 @default.
• W1976756918 countsByYear W19767569182015 @default.
• W1976756918 countsByYear W19767569182017 @default.
• W1976756918 countsByYear W19767569182018 @default.
• W1976756918 countsByYear W19767569182020 @default.
• W1976756918 countsByYear W19767569182021 @default.
• W1976756918 countsByYear W19767569182022 @default.
• W1976756918 countsByYear W19767569182023 @default.
• W1976756918 crossrefType "journal-article" @default.
• W1976756918 hasAuthorship W1976756918A5021149113 @default.
• W1976756918 hasAuthorship W1976756918A5065139905 @default.
• W1976756918 hasAuthorship W1976756918A5075895200 @default.
• W1976756918 hasBestOaLocation W19767569181 @default.
• W1976756918 hasConcept C121608353 @default.
• W1976756918 hasConcept C126322002 @default.
• W1976756918 hasConcept C134018914 @default.
• W1976756918 hasConcept C2776438761 @default.
• W1976756918 hasConcept C2776897752 @default.
• W1976756918 hasConcept C2779707156 @default.
• W1976756918 hasConcept C2779723316 @default.
• W1976756918 hasConcept C2780192828 @default.
• W1976756918 hasConcept C502942594 @default.
• W1976756918 hasConcept C55493867 @default.
• W1976756918 hasConcept C62112901 @default.
• W1976756918 hasConcept C71924100 @default.
• W1976756918 hasConcept C86803240 @default.
• W1976756918 hasConcept C96232424 @default.
• W1976756918 hasConceptScore W1976756918C121608353 @default.
• W1976756918 hasConceptScore W1976756918C126322002 @default.
• W1976756918 hasConceptScore W1976756918C134018914 @default.
• W1976756918 hasConceptScore W1976756918C2776438761 @default.

• next