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- W1976759518 endingPage "182" @default.
- W1976759518 startingPage "159" @default.
- W1976759518 abstract "Although associational/commissural (A/C) and perforant path (PP) inputs to CA3b pyramidal cells play a central role in hippocampal mnemonic functions, the active and passive processes that shape A/C and PP AMPA and NMDA receptor-mediated unitary EPSP/EPSC (AMPA and NMDA uEPSP/uEPSC) have not been fully characterized yet. Here we find no differences in somatic amplitude between A/C and PP for either AMPA or NMDA uEPSPs. However, larger AMPA uEPSCs were evoked from proximal than from distal A/C or PP. Given the space-clamp constraints in CA3 pyramidal cells, these voltage clamp data suggest that the location-independence of A/C and PP AMPA uEPSP amplitudes is achieved in part through the activation of voltage dependent conductances at or near the soma. Moreover, similarity in uEPSC amplitudes for distal A/C and PP points to the additional participation of unclamped active conductances. Indeed, the pharmacological blockade of voltage-dependent conductances eliminates the location-independence of these inputs. In contrast, the location-independence of A/C and PP NMDA uEPSP/uEPSC amplitudes is maintained across all conditions indicating that propagation is not affected by active membrane processes. The location-independence for A/C uEPSP amplitudes may be relevant in the recruitment of CA3 pyramidal cells by other CA3 pyramidal cells. These data also suggest that PP excitation represents a significant input to CA3 pyramidal cells. Implication of the passive data on local synaptic properties is further investigated in the companion paper with a detailed computational model." @default.
- W1976759518 created "2016-06-24" @default.
- W1976759518 creator A5015139621 @default.
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- W1976759518 date "2011-01-05" @default.
- W1976759518 modified "2023-10-18" @default.
- W1976759518 title "Passive and active shaping of unitary responses from associational/commissural and perforant path synapses in hippocampal CA3 pyramidal cells" @default.
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- W1976759518 doi "https://doi.org/10.1007/s10827-010-0303-y" @default.
- W1976759518 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3560390" @default.
- W1976759518 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21207127" @default.
- W1976759518 hasPublicationYear "2011" @default.