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• W1976783237 startingPage "825" @default.
• W1976783237 abstract "Multistranded helical structures in nucleic acids play various functions in biological processes. Here we report the crystal structure of a hexamer, rU(BrdG)r(AGGU),at 1.5 Å resolution containing a structural complex of an alternating antiparallel eight-stranded helical fragment that is sandwiched in two tetraplexes. The octaplex is formed by groove binding interaction and base tetrad intercalation between two tetraplexes. Two different forms of octaplexes have been proposed, which display different properties in interaction with proteins and nucleic acids. Adenines form a base tetrad in the novel N6-H…N3 conformation and further interact with uridines to form an adenine-uridine octad in the reverse Hoogsteen pairing scheme. The conformational flexibility of adenine tetrad indicates that it can optimize its conformation in different interactions." @default.
• W1976783237 created "2016-06-24" @default.
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• W1976783237 date "2003-07-01" @default.
• W1976783237 modified "2023-10-18" @default.
• W1976783237 title "An Eight-Stranded Helical Fragment in RNA Crystal Structure" @default.
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• W1976783237 doi "https://doi.org/10.1016/s0969-2126(03)00108-4" @default.
• W1976783237 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12842045" @default.
• W1976783237 hasPublicationYear "2003" @default.
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