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• W1976784378 abstract "Nonsteroidal antiinflammatory drugs (NSAIDs) are the most frequently prescribed medication for chronic pain. Gastrointestinal complications from NSAID treatment are a major cause of morbidity and mortality. In the majority of patients, NSAID induced gastropathy is superficial and self-limiting. However, peptic ulcers develop in some patients and may lead to hemorrhage, perforation, or death. NSAIDs can cause gastrointestinal damage via topical injury of the mucosal barrier, systemic inhibition of prostaglandin synthesis or a combination of both. Risk factors for NSAID related complications include age >s 60 years, history of ulcer disease, concomitant corticosteroid or anticoagulant use, high dose therapy, and multiple NSAID use. Identifying high-risk patients is critical in order to minimize risk. Factors suggested to predict the safety of NSAIDs include selective COX-2 inhibition, absence of enterohepatic circulation, shorter half-life, and nonacidic pro-drug formulations. The COX-2 selective NSAIDs, ce..." @default.
• W1976784378 created "2016-06-24" @default.
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• W1976784378 date "2000-01-01" @default.
• W1976784378 modified "2023-09-28" @default.
• W1976784378 title "Prevention and Management of NSAID-Induced Gastropathy" @default.
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• W1976784378 doi "https://doi.org/10.1300/j088v08n04_04" @default.
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