Matches in SemOpenAlex for { <https://semopenalex.org/work/W1976788351> ?p ?o ?g. }
Showing items 1 to 86 of
86
with 100 items per page.
- W1976788351 endingPage "176" @default.
- W1976788351 startingPage "171" @default.
- W1976788351 abstract "We have examined the effect of transforming growth factor beta(1) (TGF-beta(1)) and overexpression of the Smad4 gene on the phenotype of Car C, a ras mutated highly malignant spindle carcinoma cell line. TGF-beta(1)-treated Car C cells overexpressing Smad4 spread with a flattened morphology with membrane ruffles abundant in vinculin and show a reduction in their invasive abilities. TGF-beta(1) treatment and overexpression of Smad4 also enhanced the production of PAI-1 measured by the activation of the p3TP-lux reporter gene containing a PAI-1-related promoter. This activation was abolished with a dominant-negative Smad4 construct. These results lead us to conclude that both TGF-beta(1) and Smad4 overexpression reduce the invasive potential of Car C cells, probably via the Smad pathway." @default.
- W1976788351 created "2016-06-24" @default.
- W1976788351 creator A5020288422 @default.
- W1976788351 creator A5066883045 @default.
- W1976788351 creator A5078606624 @default.
- W1976788351 date "2002-05-08" @default.
- W1976788351 modified "2023-09-26" @default.
- W1976788351 title "TGF-β1and Smad4 overexpression induce a less invasive phenotype in highly invasive spindle carcinoma cells" @default.
- W1976788351 cites W1497005060 @default.
- W1976788351 cites W1544026316 @default.
- W1976788351 cites W1967072553 @default.
- W1976788351 cites W1972199574 @default.
- W1976788351 cites W1985651419 @default.
- W1976788351 cites W1985793111 @default.
- W1976788351 cites W2009629707 @default.
- W1976788351 cites W2022896763 @default.
- W1976788351 cites W2026460094 @default.
- W1976788351 cites W2046425054 @default.
- W1976788351 cites W2046879173 @default.
- W1976788351 cites W2052520421 @default.
- W1976788351 cites W2059644165 @default.
- W1976788351 cites W2069911905 @default.
- W1976788351 cites W2070033435 @default.
- W1976788351 cites W2081589439 @default.
- W1976788351 cites W2083431364 @default.
- W1976788351 cites W2097829282 @default.
- W1976788351 cites W2100522747 @default.
- W1976788351 cites W2133462388 @default.
- W1976788351 cites W2135745305 @default.
- W1976788351 doi "https://doi.org/10.1016/s0014-5793(02)02760-6" @default.
- W1976788351 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12044892" @default.
- W1976788351 hasPublicationYear "2002" @default.
- W1976788351 type Work @default.
- W1976788351 sameAs 1976788351 @default.
- W1976788351 citedByCount "5" @default.
- W1976788351 crossrefType "journal-article" @default.
- W1976788351 hasAuthorship W1976788351A5020288422 @default.
- W1976788351 hasAuthorship W1976788351A5066883045 @default.
- W1976788351 hasAuthorship W1976788351A5078606624 @default.
- W1976788351 hasBestOaLocation W19767883511 @default.
- W1976788351 hasConcept C104317684 @default.
- W1976788351 hasConcept C118131993 @default.
- W1976788351 hasConcept C127716648 @default.
- W1976788351 hasConcept C153911025 @default.
- W1976788351 hasConcept C185592680 @default.
- W1976788351 hasConcept C2778229498 @default.
- W1976788351 hasConcept C2781080636 @default.
- W1976788351 hasConcept C502942594 @default.
- W1976788351 hasConcept C54355233 @default.
- W1976788351 hasConcept C81885089 @default.
- W1976788351 hasConcept C86803240 @default.
- W1976788351 hasConcept C95444343 @default.
- W1976788351 hasConceptScore W1976788351C104317684 @default.
- W1976788351 hasConceptScore W1976788351C118131993 @default.
- W1976788351 hasConceptScore W1976788351C127716648 @default.
- W1976788351 hasConceptScore W1976788351C153911025 @default.
- W1976788351 hasConceptScore W1976788351C185592680 @default.
- W1976788351 hasConceptScore W1976788351C2778229498 @default.
- W1976788351 hasConceptScore W1976788351C2781080636 @default.
- W1976788351 hasConceptScore W1976788351C502942594 @default.
- W1976788351 hasConceptScore W1976788351C54355233 @default.
- W1976788351 hasConceptScore W1976788351C81885089 @default.
- W1976788351 hasConceptScore W1976788351C86803240 @default.
- W1976788351 hasConceptScore W1976788351C95444343 @default.
- W1976788351 hasIssue "1-3" @default.
- W1976788351 hasLocation W19767883511 @default.
- W1976788351 hasLocation W19767883512 @default.
- W1976788351 hasOpenAccess W1976788351 @default.
- W1976788351 hasPrimaryLocation W19767883511 @default.
- W1976788351 hasRelatedWork W1963767618 @default.
- W1976788351 hasRelatedWork W2033455982 @default.
- W1976788351 hasRelatedWork W2321750072 @default.
- W1976788351 hasRelatedWork W2325504614 @default.
- W1976788351 hasRelatedWork W2482631943 @default.
- W1976788351 hasRelatedWork W2506244296 @default.
- W1976788351 hasRelatedWork W2519352828 @default.
- W1976788351 hasRelatedWork W3000949338 @default.
- W1976788351 hasRelatedWork W3086196372 @default.
- W1976788351 hasRelatedWork W4361265810 @default.
- W1976788351 hasVolume "520" @default.
- W1976788351 isParatext "false" @default.
- W1976788351 isRetracted "false" @default.
- W1976788351 magId "1976788351" @default.
- W1976788351 workType "article" @default.