Matches in SemOpenAlex for { <https://semopenalex.org/work/W1976801241> ?p ?o ?g. }
Showing items 1 to 86 of
86
with 100 items per page.
- W1976801241 endingPage "6" @default.
- W1976801241 startingPage "3" @default.
- W1976801241 abstract "Objectives Increased levels of dopamine transporter (DAT) binding have been reported in patients with major depression. We used the selective DAT radiopharmaceutical 99mTc-TRODAT-1 and SPECT brain imaging, to examine differences in DAT levels in healthy subjects with and without depressive affect. Methods We compared striatal DAT binding affinity in 73 healthy subjects to their scores on the depressive symptoms subscale of the Profile of Mood States (POMS). Regions of interest in the basal ganglia of the brain were examined. Distribution volume ratios (DVRs) of 99mTc-TRODAT-1 binding affinity were calculated from the SPECT scan data, and comparisons among subjects with low and high depressive symptom ratings were calculated using unpaired t-tests and the Pearson correlation. Results We observed a greater 99mTc-TRODAT-1 DVR in the right caudate of subjects with high POMS mood scores compared to subjects with low scores on depressive items on the POMS (2.99±0.35 and 2.79±0.35, respectively; P=0.009). There was also a weak, but significant correlation between higher 99mTc-TRODAT-1 DVRs in the right caudate and depressive symptoms scores (r=0.23, P=0.05). Conclusions These data suggest that 99mTc-TRODAT-1 binding affinity to DAT sites may be associated with depressive affect in healthy subjects. The finding also supports prior observations of greater 99mTc-TRODAT-1 DVRs in patients with major depressive episode." @default.
- W1976801241 created "2016-06-24" @default.
- W1976801241 creator A5002520132 @default.
- W1976801241 creator A5046106672 @default.
- W1976801241 creator A5047129280 @default.
- W1976801241 date "2007-01-01" @default.
- W1976801241 modified "2023-09-25" @default.
- W1976801241 title "Dopamine transporter density may be associated with the depressed affect in healthy subjects" @default.
- W1976801241 cites W1530899316 @default.
- W1976801241 cites W1910313789 @default.
- W1976801241 cites W1964177118 @default.
- W1976801241 cites W1977430165 @default.
- W1976801241 cites W1986552785 @default.
- W1976801241 cites W2014793858 @default.
- W1976801241 cites W2015933168 @default.
- W1976801241 cites W2018294624 @default.
- W1976801241 cites W2027702949 @default.
- W1976801241 cites W2030078771 @default.
- W1976801241 cites W2036602098 @default.
- W1976801241 cites W2047456762 @default.
- W1976801241 cites W2055891072 @default.
- W1976801241 cites W2061011449 @default.
- W1976801241 cites W2082362868 @default.
- W1976801241 cites W2092024217 @default.
- W1976801241 cites W2142801688 @default.
- W1976801241 cites W2147600591 @default.
- W1976801241 cites W2149251203 @default.
- W1976801241 cites W4253135703 @default.
- W1976801241 doi "https://doi.org/10.1097/mnm.0b013e328013dc9d" @default.
- W1976801241 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17159542" @default.
- W1976801241 hasPublicationYear "2007" @default.
- W1976801241 type Work @default.
- W1976801241 sameAs 1976801241 @default.
- W1976801241 citedByCount "26" @default.
- W1976801241 countsByYear W19768012412012 @default.
- W1976801241 countsByYear W19768012412013 @default.
- W1976801241 countsByYear W19768012412014 @default.
- W1976801241 countsByYear W19768012412020 @default.
- W1976801241 countsByYear W19768012412021 @default.
- W1976801241 countsByYear W19768012412022 @default.
- W1976801241 crossrefType "journal-article" @default.
- W1976801241 hasAuthorship W1976801241A5002520132 @default.
- W1976801241 hasAuthorship W1976801241A5046106672 @default.
- W1976801241 hasAuthorship W1976801241A5047129280 @default.
- W1976801241 hasConcept C118552586 @default.
- W1976801241 hasConcept C126322002 @default.
- W1976801241 hasConcept C137183658 @default.
- W1976801241 hasConcept C15744967 @default.
- W1976801241 hasConcept C2776035688 @default.
- W1976801241 hasConcept C2776755682 @default.
- W1976801241 hasConcept C2780733359 @default.
- W1976801241 hasConcept C46312422 @default.
- W1976801241 hasConcept C513476851 @default.
- W1976801241 hasConcept C71924100 @default.
- W1976801241 hasConceptScore W1976801241C118552586 @default.
- W1976801241 hasConceptScore W1976801241C126322002 @default.
- W1976801241 hasConceptScore W1976801241C137183658 @default.
- W1976801241 hasConceptScore W1976801241C15744967 @default.
- W1976801241 hasConceptScore W1976801241C2776035688 @default.
- W1976801241 hasConceptScore W1976801241C2776755682 @default.
- W1976801241 hasConceptScore W1976801241C2780733359 @default.
- W1976801241 hasConceptScore W1976801241C46312422 @default.
- W1976801241 hasConceptScore W1976801241C513476851 @default.
- W1976801241 hasConceptScore W1976801241C71924100 @default.
- W1976801241 hasIssue "1" @default.
- W1976801241 hasLocation W19768012411 @default.
- W1976801241 hasLocation W19768012412 @default.
- W1976801241 hasOpenAccess W1976801241 @default.
- W1976801241 hasPrimaryLocation W19768012411 @default.
- W1976801241 hasRelatedWork W1973576252 @default.
- W1976801241 hasRelatedWork W1997975262 @default.
- W1976801241 hasRelatedWork W2004875175 @default.
- W1976801241 hasRelatedWork W2019484765 @default.
- W1976801241 hasRelatedWork W2025483729 @default.
- W1976801241 hasRelatedWork W2030104137 @default.
- W1976801241 hasRelatedWork W2468271471 @default.
- W1976801241 hasRelatedWork W2748952813 @default.
- W1976801241 hasRelatedWork W2899084033 @default.
- W1976801241 hasRelatedWork W2919532134 @default.
- W1976801241 hasVolume "28" @default.
- W1976801241 isParatext "false" @default.
- W1976801241 isRetracted "false" @default.
- W1976801241 magId "1976801241" @default.
- W1976801241 workType "article" @default.