FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1976804439> ?p ?o ?g. }

• W1976804439 endingPage "9" @default.
• W1976804439 startingPage "1655" @default.
• W1976804439 abstract "We assessed the influence of the histological response to intravesical bacillus Calmette-Guerin (BCG) and the prevalence of p53 nuclear accumulation on the clinical behavior of patients with carcinoma in situ.Of 60 patients with Bergquist grade 3 carcinoma in situ 13 had primary and 47 had secondary carcinoma in situ. Patients received 6 weekly instillations and nonresponders received an additional 6 instillations at 2-week intervals. No maintenance was administered. Median followup was 48 months. The p53 nuclear accumulation was detected by immunohistochemical analysis with antibody PAb 1801.The complete histological response rate to BCG therapy was 64%, which decreased to 52% at 4 years. BCG was more effective for treatment of primary than secondary carcinoma in situ (complete response rate 85 versus 57%, respectively). The 45% progression rate was related to the initial histological response occurring in 26% of patients with a complete versus 77% with a partial and no response. Consequently, the progression rate was only 8% for primary versus 57% for secondary carcinoma in situ. Of the patients receiving only 1 course of BCG 40% had progression compared to 62% of those who received 2 courses. Patients in whom both courses failed had a progression rate of 89%. Intravesical BCG converted the p53 nuclear immunoreactivity from positive to negative in 73% of the 26 patients expressing reactivity before treatment, of whom 68% also had a complete response. The progression rate was related to the prevalence of p53 nuclear reactivity after but not before treatment (90% of patients with versus 37% without p53 nuclear accumulation had progression). All 3 complete responders with p53 nuclear reactivity after BCG had progression, which suggests that molecular genetic change may precede histological change. Complete responders without p53 nuclear accumulation after BCG treatment experienced the lowest progression rate (21%).Our results suggest that patients with a persistent complete histological response and without p53 nuclear accumulation after BCG treatment can be followed conservatively. Cystectomy should be considered in all other patients." @default.
• W1976804439 created "2016-06-24" @default.
• W1976804439 creator A5012687055 @default.
• W1976804439 creator A5038133469 @default.
• W1976804439 creator A5091595067 @default.
• W1976804439 date "1997-05-01" @default.
• W1976804439 modified "2023-10-14" @default.
• W1976804439 title "Long-term efficacy of intravesical bacillus Calmette-Guerin for carcinoma in situ: relationship of progression to histological response and p53 nuclear accumulation." @default.
• W1976804439 cites W122123081 @default.
• W1976804439 cites W1571175410 @default.
• W1976804439 cites W162594705 @default.
• W1976804439 cites W192633127 @default.
• W1976804439 cites W1973948212 @default.
• W1976804439 cites W1979300931 @default.
• W1976804439 cites W1991274574 @default.
• W1976804439 cites W1991697781 @default.
• W1976804439 cites W2022146756 @default.
• W1976804439 cites W2046376751 @default.
• W1976804439 cites W2049259485 @default.
• W1976804439 cites W2167937794 @default.
• W1976804439 cites W229419814 @default.
• W1976804439 cites W2402487223 @default.
• W1976804439 cites W2410257367 @default.
• W1976804439 cites W2411417005 @default.
• W1976804439 cites W2413740587 @default.
• W1976804439 cites W2417712782 @default.
• W1976804439 cites W2418998907 @default.
• W1976804439 cites W2470130076 @default.
• W1976804439 cites W26171313 @default.
• W1976804439 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9112499" @default.
• W1976804439 hasPublicationYear "1997" @default.
• W1976804439 type Work @default.
• W1976804439 sameAs 1976804439 @default.
• W1976804439 citedByCount "16" @default.
• W1976804439 countsByYear W19768044392015 @default.
• W1976804439 countsByYear W19768044392018 @default.
• W1976804439 crossrefType "journal-article" @default.
• W1976804439 hasAuthorship W1976804439A5012687055 @default.
• W1976804439 hasAuthorship W1976804439A5038133469 @default.
• W1976804439 hasAuthorship W1976804439A5091595067 @default.
• W1976804439 hasConcept C121608353 @default.
• W1976804439 hasConcept C126322002 @default.
• W1976804439 hasConcept C126894567 @default.
• W1976804439 hasConcept C142724271 @default.
• W1976804439 hasConcept C2776283816 @default.
• W1976804439 hasConcept C2777546739 @default.
• W1976804439 hasConcept C2777661416 @default.
• W1976804439 hasConcept C2779256057 @default.
• W1976804439 hasConcept C71924100 @default.
• W1976804439 hasConcept C90924648 @default.
• W1976804439 hasConceptScore W1976804439C121608353 @default.
• W1976804439 hasConceptScore W1976804439C126322002 @default.
• W1976804439 hasConceptScore W1976804439C126894567 @default.
• W1976804439 hasConceptScore W1976804439C142724271 @default.
• W1976804439 hasConceptScore W1976804439C2776283816 @default.
• W1976804439 hasConceptScore W1976804439C2777546739 @default.
• W1976804439 hasConceptScore W1976804439C2777661416 @default.
• W1976804439 hasConceptScore W1976804439C2779256057 @default.
• W1976804439 hasConceptScore W1976804439C71924100 @default.
• W1976804439 hasConceptScore W1976804439C90924648 @default.
• W1976804439 hasIssue "5" @default.
• W1976804439 hasLocation W19768044391 @default.
• W1976804439 hasOpenAccess W1976804439 @default.
• W1976804439 hasPrimaryLocation W19768044391 @default.
• W1976804439 hasRelatedWork W14333632 @default.
• W1976804439 hasRelatedWork W2006911370 @default.
• W1976804439 hasRelatedWork W2054260024 @default.
• W1976804439 hasRelatedWork W2075064101 @default.
• W1976804439 hasRelatedWork W2095694162 @default.
• W1976804439 hasRelatedWork W2147779944 @default.
• W1976804439 hasRelatedWork W2168881876 @default.
• W1976804439 hasRelatedWork W2415382229 @default.
• W1976804439 hasRelatedWork W2912851634 @default.
• W1976804439 hasRelatedWork W3025709098 @default.
• W1976804439 hasVolume "157" @default.
• W1976804439 isParatext "false" @default.
• W1976804439 isRetracted "false" @default.
• W1976804439 magId "1976804439" @default.
• W1976804439 workType "article" @default.