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• W1976805038 endingPage "1185" @default.
• W1976805038 startingPage "1175" @default.
• W1976805038 abstract "This study examined the relative role of FSH and LH in governing testicular inhibin B secretion in the rhesus monkey. Adult male monkeys, rendered hypogonadotropic and hypogonadal by administration of a GnRH receptor antagonist (acyline), were implanted with testosterone (T)-filled or empty capsules. Following T-induced restoration of spermatogenesis, both groups received recombinant human FSH and vehicle for 12 d. Juvenile male monkeys received an 11-d infusion of single-chain recombinant human LH and recombinant human FSH, either alone or in combination. In adults, chronic hypogonadotropism resulted in a modest reduction of circulating inhibin B levels, which was more than fully reversed by FSH. In the presence of T, which exerted a marked suppression in inhibin B secretion, FSH restored inhibin B levels only to those observed before acyline treatment. In juveniles, treatment with single-chain recombinant human LH led to a suppression of inhibin B secretion and curtailed the FSH-induced stimulation of this testicular hormone. The T-induced decrease in inhibin B secretion was associated with suppression in inhibin-beta(B) mRNA levels, but FSH stimulation of inhibin B secretion occurred in the absence of clear changes in expression of this subunit gene. These findings indicate that inhibin B secretion by the monkey testis is governed by the inhibitory and stimulatory action of LH and FSH, respectively. The action of LH is presumably indirect and likely mediated by T inhibition of inhibin-beta(B) gene expression. The molecular basis of the stimulatory action of FSH on inhibin B secretion requires further study." @default.
• W1976805038 created "2016-06-24" @default.
• W1976805038 creator A5009595522 @default.
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• W1976805038 creator A5058968656 @default.
• W1976805038 creator A5073019775 @default.
• W1976805038 creator A5085356820 @default.
• W1976805038 date "2003-04-01" @default.
• W1976805038 modified "2023-09-22" @default.
• W1976805038 title "Inhibitory and Stimulatory Regulation of Testicular Inhibin B Secretion by Luteinizing Hormone and Follicle-Stimulating Hormone, Respectively, in the Rhesus Monkey (<i>Macaca mulatta</i>)" @default.
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• W1976805038 doi "https://doi.org/10.1210/en.2002-221078" @default.
• W1976805038 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12639898" @default.
• W1976805038 hasPublicationYear "2003" @default.
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