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• W1976808064 endingPage "442" @default.
• W1976808064 startingPage "435" @default.
• W1976808064 abstract "Effects of buprenorphine, U-50,488H, naltrexone and lithium chloride on cocaine conditioned place preference were examined. Buprenorphine, a mixed opioid agonist-antagonist, blocked the cocaine-induced place preference. Furthermore, the kappa-receptor agonist U-50,488H and the mu-receptor antagonist naltrexone both antagonized the cocaine preference. U-50,488H or naltrexone alone induced a place aversion in a dose-dependent manner. However, the cocaine-induced conditioned place preference was not blocked by lithium chloride, although the latter induced a conditioned place aversion, indicating that the antagonism of cocaine-induced place preference by U-50,488H or naltrexone does not result from a functional antagonism. These results suggest that mu- and kappa-opioid receptors may be involved in cocaine-induced conditioned place preference." @default.
• W1976808064 created "2016-06-24" @default.
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• W1976808064 date "1992-01-01" @default.
• W1976808064 modified "2023-09-25" @default.
• W1976808064 title "The Role of Mu- and Kappa-Opioid Receptors in Cocaine-Induced Conditioned Place Preference." @default.
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• W1976808064 doi "https://doi.org/10.1254/jjp.58.435" @default.
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