Matches in SemOpenAlex for { <https://semopenalex.org/work/W1976819386> ?p ?o ?g. }
- W1976819386 endingPage "5385" @default.
- W1976819386 startingPage "5378" @default.
- W1976819386 abstract "Osteopontin (OPN) is a multifunctional bioactive protein that is implicated in numerous biological processes such as bone remodeling, inhibition of ectopic calcification, and cellular adhesion and migration, as well as several immune functions. Osteopontin has cytokine-like properties and is a key factor in the initiation of T helper 1 immune responses. Osteopontin is present in most tissues and body fluids, with the highest concentrations being found in milk. In the present study, ELISA for human and bovine milk OPN were developed and OPN concentration in human breast milk, bovine milk, and infant formulas was measured and compared. The OPN concentration in human milk was measured to approximately 138 mg/L, which corresponds to 2.1% (wt/wt) of the total protein in human breast milk. This is considerably higher than the corresponding OPN concentrations in bovine milk (∼18 mg/L) and infant formulas (∼9 mg/L). Moreover, bovine milk OPN is shown to induce the expression of the T helper 1 cytokine IL-12 in cultured human lamina propria mononuclear cells isolated from intestinal biopsies. Finally, the OPN concentration in plasma samples from umbilical cords, 3-mo-old infants, and pregnant and nonpregnant adults was measured. The OPN level in plasma from 3-mo-old infants and umbilical cords was found to be 7 to 10 times higher than in adults. Thus, the high levels of OPN in milk and infant plasma suggest that OPN is important to infants and that ingested milk OPN is likely to induce cytokine production in neonate intestinal immune cells." @default.
- W1976819386 created "2016-06-24" @default.
- W1976819386 creator A5010647729 @default.
- W1976819386 creator A5021900786 @default.
- W1976819386 creator A5035095353 @default.
- W1976819386 creator A5045782833 @default.
- W1976819386 creator A5064667098 @default.
- W1976819386 creator A5071012216 @default.
- W1976819386 creator A5089518876 @default.
- W1976819386 date "2009-11-01" @default.
- W1976819386 modified "2023-10-16" @default.
- W1976819386 title "Considerable variation in the concentration of osteopontin in human milk, bovine milk, and infant formulas" @default.
- W1976819386 cites W1971147172 @default.
- W1976819386 cites W1976462519 @default.
- W1976819386 cites W1981168090 @default.
- W1976819386 cites W1985691031 @default.
- W1976819386 cites W1991733645 @default.
- W1976819386 cites W1995214526 @default.
- W1976819386 cites W2000465836 @default.
- W1976819386 cites W2006877529 @default.
- W1976819386 cites W2007903893 @default.
- W1976819386 cites W2012358574 @default.
- W1976819386 cites W2015546687 @default.
- W1976819386 cites W2016064855 @default.
- W1976819386 cites W2024978791 @default.
- W1976819386 cites W2029470445 @default.
- W1976819386 cites W2030167715 @default.
- W1976819386 cites W2032704852 @default.
- W1976819386 cites W2033701025 @default.
- W1976819386 cites W2040350967 @default.
- W1976819386 cites W2040370843 @default.
- W1976819386 cites W2041595300 @default.
- W1976819386 cites W2050733826 @default.
- W1976819386 cites W2057455941 @default.
- W1976819386 cites W2063398359 @default.
- W1976819386 cites W2063979780 @default.
- W1976819386 cites W2069711840 @default.
- W1976819386 cites W2089794703 @default.
- W1976819386 cites W2116995403 @default.
- W1976819386 cites W2120530897 @default.
- W1976819386 cites W2127668346 @default.
- W1976819386 cites W2137006641 @default.
- W1976819386 cites W2138745399 @default.
- W1976819386 cites W2155450435 @default.
- W1976819386 cites W2164561524 @default.
- W1976819386 cites W2166939260 @default.
- W1976819386 cites W2168724234 @default.
- W1976819386 cites W2171405904 @default.
- W1976819386 cites W4211142228 @default.
- W1976819386 doi "https://doi.org/10.3168/jds.2009-2360" @default.
- W1976819386 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19841198" @default.
- W1976819386 hasPublicationYear "2009" @default.
- W1976819386 type Work @default.
- W1976819386 sameAs 1976819386 @default.
- W1976819386 citedByCount "107" @default.
- W1976819386 countsByYear W19768193862012 @default.
- W1976819386 countsByYear W19768193862013 @default.
- W1976819386 countsByYear W19768193862014 @default.
- W1976819386 countsByYear W19768193862015 @default.
- W1976819386 countsByYear W19768193862016 @default.
- W1976819386 countsByYear W19768193862017 @default.
- W1976819386 countsByYear W19768193862018 @default.
- W1976819386 countsByYear W19768193862019 @default.
- W1976819386 countsByYear W19768193862020 @default.
- W1976819386 countsByYear W19768193862021 @default.
- W1976819386 countsByYear W19768193862022 @default.
- W1976819386 countsByYear W19768193862023 @default.
- W1976819386 crossrefType "journal-article" @default.
- W1976819386 hasAuthorship W1976819386A5010647729 @default.
- W1976819386 hasAuthorship W1976819386A5021900786 @default.
- W1976819386 hasAuthorship W1976819386A5035095353 @default.
- W1976819386 hasAuthorship W1976819386A5045782833 @default.
- W1976819386 hasAuthorship W1976819386A5064667098 @default.
- W1976819386 hasAuthorship W1976819386A5071012216 @default.
- W1976819386 hasAuthorship W1976819386A5089518876 @default.
- W1976819386 hasBestOaLocation W19768193861 @default.
- W1976819386 hasConcept C126322002 @default.
- W1976819386 hasConcept C134018914 @default.
- W1976819386 hasConcept C16685009 @default.
- W1976819386 hasConcept C185592680 @default.
- W1976819386 hasConcept C203014093 @default.
- W1976819386 hasConcept C2775871700 @default.
- W1976819386 hasConcept C2778690821 @default.
- W1976819386 hasConcept C2779150110 @default.
- W1976819386 hasConcept C2780804394 @default.
- W1976819386 hasConcept C2992940123 @default.
- W1976819386 hasConcept C31903555 @default.
- W1976819386 hasConcept C55493867 @default.
- W1976819386 hasConcept C71924100 @default.
- W1976819386 hasConcept C86803240 @default.
- W1976819386 hasConcept C8891405 @default.
- W1976819386 hasConceptScore W1976819386C126322002 @default.
- W1976819386 hasConceptScore W1976819386C134018914 @default.
- W1976819386 hasConceptScore W1976819386C16685009 @default.
- W1976819386 hasConceptScore W1976819386C185592680 @default.
- W1976819386 hasConceptScore W1976819386C203014093 @default.
- W1976819386 hasConceptScore W1976819386C2775871700 @default.
- W1976819386 hasConceptScore W1976819386C2778690821 @default.