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- W1976819881 abstract "Earlier work from two laboratories had shown that three mouse strains of allotype b produce a restricted response to hapten (4-hydroxy-3-nitrophenyl) acetyl (NP). These antibodies shared a peculiar heteroclitic fine specificity and exhibited a predictable although polyclonal isoelectric focusing (IEF) pattern in most of these mice. These characteristics were controlled by (an) Ig-1-linked gene(s) (VHNFb). We report studies with a guinea pig anti-idiotype serum which recognized the products of the VHNPb gene (idiotype NP-b) but not other Ig. Binding of idiotype NP-b was hapten-inhibitable. Idiotype NP-b was the predominant (> 85%) antibody population in the primary and secondary responses of C57BL/6, and also in F1 hybrid mice between C57BL/6 and an idiotype-negative strain. By preparative IEF, idiotype NP-b was separated into fractions (IgG1(λ) which had different affinities for the anti-idiotype, and also slightly different binding affinities for analogues of NP. Lambda1 light chain seems to be required for the expression of the idiotype gene, but with the exception of the SJL strain, the light chain is not responsible for the observed genetic polymorphism. Besides, λ is the predominant light chain in idiotype-negative anti-NP antibodies at least in strains BALB/c, SM, DBA, A/J and RF but not in strains CBA, AKR, NZB and SJL." @default.
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- W1976819881 date "1978-02-01" @default.
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- W1976819881 title "A mendelian idiotype is demonstrable in the heteroclitic anti-NP antibodies of the mouse" @default.
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- W1976819881 doi "https://doi.org/10.1002/eji.1830080207" @default.
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