Matches in SemOpenAlex for { <https://semopenalex.org/work/W1976855711> ?p ?o ?g. }
Showing items 1 to 90 of
90
with 100 items per page.
- W1976855711 abstract "This study aimed at evaluating the in vitro antioxidant and hepatoprotective activities of different stem bark extracts of Erythrina senegalensis prepared with ethanol, and the in vivo hepatoprotective activity and acute toxicity of the best extract. The 2, 4-diphenyl-1-picryl-hydrazil (DPPH) and microsomal lipid peroxidation (MLP) models, and the rat liver slices system were respectively used for the in vitro study. The Methylene chloride/methanol (1:1 v/v) (Emc) and 40% ethanolic (E40) extracts were more efficient in inhibiting MLP and in scavenging DPPH radical. However, E40 was most effective with regards to lactate dehydrogenase (LDH) leakage inhibition from rat liver slices intoxicated with carbon tetrachloride (CCl4). The in vivo hepatoprotective activity was evaluated against CCl4-induced hepatotoxicity in rats. The E40 extract (100 mg/Kg) significantly reduced the increase in ALT, AST and lipid peroxidation in liver homogenate, showing that the extract is as protective as silymarin at the same dose. Acute toxicity was evaluated in mice and E40 did not produce any behavioural changes or mortality even at an oral dose of 16 g/kg. The extract was found to contain antioxidant classes of compounds (flavonoids and polyphenols). In conclusion, the E40 extract of E. senegalensis could be an important source of hepatoprotective compounds.Key words: Erythrina senegalensis, stem bark extract, antioxidant, hepatoprotective, carbon tetrachloride." @default.
- W1976855711 created "2016-06-24" @default.
- W1976855711 creator A5005608762 @default.
- W1976855711 creator A5035758000 @default.
- W1976855711 creator A5037545912 @default.
- W1976855711 creator A5044885199 @default.
- W1976855711 creator A5054713446 @default.
- W1976855711 creator A5059716391 @default.
- W1976855711 creator A5070862467 @default.
- W1976855711 date "2010-10-05" @default.
- W1976855711 modified "2023-10-18" @default.
- W1976855711 title "Hepato-protective, antioxidant activities and acute toxicity of a stem bark extract of <i>Erythrina senegalensis</i> DC." @default.
- W1976855711 doi "https://doi.org/10.4314/ijbcs.v4i3.60503" @default.
- W1976855711 hasPublicationYear "2010" @default.
- W1976855711 type Work @default.
- W1976855711 sameAs 1976855711 @default.
- W1976855711 citedByCount "4" @default.
- W1976855711 countsByYear W19768557112013 @default.
- W1976855711 countsByYear W19768557112014 @default.
- W1976855711 countsByYear W19768557112017 @default.
- W1976855711 crossrefType "journal-article" @default.
- W1976855711 hasAuthorship W1976855711A5005608762 @default.
- W1976855711 hasAuthorship W1976855711A5035758000 @default.
- W1976855711 hasAuthorship W1976855711A5037545912 @default.
- W1976855711 hasAuthorship W1976855711A5044885199 @default.
- W1976855711 hasAuthorship W1976855711A5054713446 @default.
- W1976855711 hasAuthorship W1976855711A5059716391 @default.
- W1976855711 hasAuthorship W1976855711A5070862467 @default.
- W1976855711 hasBestOaLocation W19768557111 @default.
- W1976855711 hasConcept C102124568 @default.
- W1976855711 hasConcept C116263406 @default.
- W1976855711 hasConcept C149971331 @default.
- W1976855711 hasConcept C150903083 @default.
- W1976855711 hasConcept C178790620 @default.
- W1976855711 hasConcept C181199279 @default.
- W1976855711 hasConcept C185592680 @default.
- W1976855711 hasConcept C207001950 @default.
- W1976855711 hasConcept C2776637226 @default.
- W1976855711 hasConcept C2777318727 @default.
- W1976855711 hasConcept C2777359374 @default.
- W1976855711 hasConcept C2778004101 @default.
- W1976855711 hasConcept C2780829032 @default.
- W1976855711 hasConcept C2781401929 @default.
- W1976855711 hasConcept C29730261 @default.
- W1976855711 hasConcept C55493867 @default.
- W1976855711 hasConcept C556039675 @default.
- W1976855711 hasConcept C70899900 @default.
- W1976855711 hasConcept C71924100 @default.
- W1976855711 hasConcept C86803240 @default.
- W1976855711 hasConcept C98274493 @default.
- W1976855711 hasConceptScore W1976855711C102124568 @default.
- W1976855711 hasConceptScore W1976855711C116263406 @default.
- W1976855711 hasConceptScore W1976855711C149971331 @default.
- W1976855711 hasConceptScore W1976855711C150903083 @default.
- W1976855711 hasConceptScore W1976855711C178790620 @default.
- W1976855711 hasConceptScore W1976855711C181199279 @default.
- W1976855711 hasConceptScore W1976855711C185592680 @default.
- W1976855711 hasConceptScore W1976855711C207001950 @default.
- W1976855711 hasConceptScore W1976855711C2776637226 @default.
- W1976855711 hasConceptScore W1976855711C2777318727 @default.
- W1976855711 hasConceptScore W1976855711C2777359374 @default.
- W1976855711 hasConceptScore W1976855711C2778004101 @default.
- W1976855711 hasConceptScore W1976855711C2780829032 @default.
- W1976855711 hasConceptScore W1976855711C2781401929 @default.
- W1976855711 hasConceptScore W1976855711C29730261 @default.
- W1976855711 hasConceptScore W1976855711C55493867 @default.
- W1976855711 hasConceptScore W1976855711C556039675 @default.
- W1976855711 hasConceptScore W1976855711C70899900 @default.
- W1976855711 hasConceptScore W1976855711C71924100 @default.
- W1976855711 hasConceptScore W1976855711C86803240 @default.
- W1976855711 hasConceptScore W1976855711C98274493 @default.
- W1976855711 hasIssue "3" @default.
- W1976855711 hasLocation W19768557111 @default.
- W1976855711 hasOpenAccess W1976855711 @default.
- W1976855711 hasPrimaryLocation W19768557111 @default.
- W1976855711 hasRelatedWork W1974601754 @default.
- W1976855711 hasRelatedWork W2024269343 @default.
- W1976855711 hasRelatedWork W2029702897 @default.
- W1976855711 hasRelatedWork W2077029966 @default.
- W1976855711 hasRelatedWork W2165734552 @default.
- W1976855711 hasRelatedWork W2205039294 @default.
- W1976855711 hasRelatedWork W2320723815 @default.
- W1976855711 hasRelatedWork W2751607076 @default.
- W1976855711 hasRelatedWork W3033209723 @default.
- W1976855711 hasRelatedWork W37975116 @default.
- W1976855711 hasVolume "4" @default.
- W1976855711 isParatext "false" @default.
- W1976855711 isRetracted "false" @default.
- W1976855711 magId "1976855711" @default.
- W1976855711 workType "article" @default.