FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1976871650> ?p ?o ?g. }

• W1976871650 endingPage "64" @default.
• W1976871650 startingPage "58" @default.
• W1976871650 abstract "Allergic rhinitis (AR) is a common chronic inflammatory condition of the nasal mucosal tissue. The interleukin-13 (IL-13) signaling pathway is of great importance in the pathogenesis of AR. However, how the signaling molecules in this pathway are regulated, particularly through microRNAs (miRNAs), remains unclear. In the present study, we investigated the regulatory role and mechanism of miRNA-143 (miR-143) in IL-13-induced inflammatory cytokine and mucus production in nasal epithelial cells (NECs) from AR patients. Our results showed that forced expression of miR-143 significantly decreased the mRNA and protein expression levels of granulocyte-macrophage colony-stimulating factor (GM-CSF), eotaxin and mucin 5AC (MUC5AC) in IL-13-stimulated NECs. Moreover, we confirmed that miR-143 directly targeted and significantly suppressed IL-13 receptor α1 chain (IL13Rα1) gene expression. This study thus suggests that miR-143 regulation of IL-13-induced inflammatory cytokine and mucus production in NECs from AR patients probably partly depends on inhibition of IL13Rα1. Therefore, the IL13Rα1 signaling pathway may be a potential target for the prevention and treatment of AR by miR-143." @default.
• W1976871650 created "2016-06-24" @default.
• W1976871650 creator A5033020983 @default.
• W1976871650 creator A5033251317 @default.
• W1976871650 creator A5046150247 @default.
• W1976871650 creator A5054175249 @default.
• W1976871650 creator A5079618691 @default.
• W1976871650 creator A5085880446 @default.
• W1976871650 creator A5087826088 @default.
• W1976871650 creator A5088082429 @default.
• W1976871650 date "2015-01-01" @default.
• W1976871650 modified "2023-09-29" @default.
• W1976871650 title "miR-143 inhibits interleukin-13-induced inflammatory cytokine and mucus production in nasal epithelial cells from allergic rhinitis patients by targeting IL13Rα1" @default.
• W1976871650 cites W144423133 @default.
• W1976871650 cites W1969721067 @default.
• W1976871650 cites W1969729712 @default.
• W1976871650 cites W1979732414 @default.
• W1976871650 cites W2019370193 @default.
• W1976871650 cites W2020120040 @default.
• W1976871650 cites W2024319734 @default.
• W1976871650 cites W2028835231 @default.
• W1976871650 cites W2030222836 @default.
• W1976871650 cites W2036075099 @default.
• W1976871650 cites W2042653100 @default.
• W1976871650 cites W2056897424 @default.
• W1976871650 cites W2065801967 @default.
• W1976871650 cites W2066318154 @default.
• W1976871650 cites W2076943072 @default.
• W1976871650 cites W2083153453 @default.
• W1976871650 cites W2085624556 @default.
• W1976871650 cites W2095310960 @default.
• W1976871650 cites W2095362351 @default.
• W1976871650 cites W2097346494 @default.
• W1976871650 cites W2107277218 @default.
• W1976871650 cites W2111398048 @default.
• W1976871650 cites W2121753858 @default.
• W1976871650 cites W2124566107 @default.
• W1976871650 cites W2135152690 @default.
• W1976871650 cites W2136378686 @default.
• W1976871650 cites W2171882740 @default.
• W1976871650 cites W2314048832 @default.
• W1976871650 doi "https://doi.org/10.1016/j.bbrc.2014.12.058" @default.
• W1976871650 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25529447" @default.
• W1976871650 hasPublicationYear "2015" @default.
• W1976871650 type Work @default.
• W1976871650 sameAs 1976871650 @default.
• W1976871650 citedByCount "68" @default.
• W1976871650 countsByYear W19768716502015 @default.
• W1976871650 countsByYear W19768716502016 @default.
• W1976871650 countsByYear W19768716502017 @default.
• W1976871650 countsByYear W19768716502018 @default.
• W1976871650 countsByYear W19768716502019 @default.
• W1976871650 countsByYear W19768716502020 @default.
• W1976871650 countsByYear W19768716502021 @default.
• W1976871650 countsByYear W19768716502022 @default.
• W1976871650 countsByYear W19768716502023 @default.
• W1976871650 crossrefType "journal-article" @default.
• W1976871650 hasAuthorship W1976871650A5033020983 @default.
• W1976871650 hasAuthorship W1976871650A5033251317 @default.
• W1976871650 hasAuthorship W1976871650A5046150247 @default.
• W1976871650 hasAuthorship W1976871650A5054175249 @default.
• W1976871650 hasAuthorship W1976871650A5079618691 @default.
• W1976871650 hasAuthorship W1976871650A5085880446 @default.
• W1976871650 hasAuthorship W1976871650A5087826088 @default.
• W1976871650 hasAuthorship W1976871650A5088082429 @default.
• W1976871650 hasConcept C104317684 @default.
• W1976871650 hasConcept C13373296 @default.
• W1976871650 hasConcept C142724271 @default.
• W1976871650 hasConcept C145059251 @default.
• W1976871650 hasConcept C179264091 @default.
• W1976871650 hasConcept C18903297 @default.
• W1976871650 hasConcept C203014093 @default.
• W1976871650 hasConcept C2776914184 @default.
• W1976871650 hasConcept C2777312293 @default.
• W1976871650 hasConcept C2777478134 @default.
• W1976871650 hasConcept C2777716647 @default.
• W1976871650 hasConcept C2778690821 @default.
• W1976871650 hasConcept C2780942790 @default.
• W1976871650 hasConcept C32046619 @default.
• W1976871650 hasConcept C502942594 @default.
• W1976871650 hasConcept C55493867 @default.
• W1976871650 hasConcept C62478195 @default.
• W1976871650 hasConcept C71924100 @default.
• W1976871650 hasConcept C74172505 @default.
• W1976871650 hasConcept C86803240 @default.
• W1976871650 hasConcept C95444343 @default.
• W1976871650 hasConceptScore W1976871650C104317684 @default.
• W1976871650 hasConceptScore W1976871650C13373296 @default.
• W1976871650 hasConceptScore W1976871650C142724271 @default.
• W1976871650 hasConceptScore W1976871650C145059251 @default.
• W1976871650 hasConceptScore W1976871650C179264091 @default.
• W1976871650 hasConceptScore W1976871650C18903297 @default.
• W1976871650 hasConceptScore W1976871650C203014093 @default.
• W1976871650 hasConceptScore W1976871650C2776914184 @default.
• W1976871650 hasConceptScore W1976871650C2777312293 @default.
• W1976871650 hasConceptScore W1976871650C2777478134 @default.
• W1976871650 hasConceptScore W1976871650C2777716647 @default.
• W1976871650 hasConceptScore W1976871650C2778690821 @default.

• next