Matches in SemOpenAlex for { <https://semopenalex.org/work/W1976886090> ?p ?o ?g. }
- W1976886090 endingPage "376" @default.
- W1976886090 startingPage "376" @default.
- W1976886090 abstract "Although the diverse effects of ionizing radiation on biological and pathological processes at various levels ranging from molecular to whole body are well studied, the effects on adult stem cells by ionizing radiation remain largely unknown. In this study, we characterized the functional modifications of adult Drosophila midgut intestinal stem cells after ionizing radiation treatment. A dose of 10 Gy of radiation decreased the proliferative capacity of intestinal stem cells. Interestingly, after irradiation at 2 Gy, the intestinal stem cells exhibited increased proliferative activity, misdifferentiation and γH2AvD and 8-oxo-dG levels. In addition, the guts irradiated with 2 Gy showed increased JNK and AKT activities. Furthermore, we showed that 2 Gy of ionizing radiation induced centrosome amplification in intestinal stem cells of adult midguts. Our data gives molecular insights into the effects of ionizing radiation on functional modifications of stem cells. The adult Drosophila midgut intestinal stem cells offer a potentially rich new system for the exploration of the biological effects of ionizing radiation." @default.
- W1976886090 created "2016-06-24" @default.
- W1976886090 creator A5021541241 @default.
- W1976886090 creator A5031356545 @default.
- W1976886090 creator A5037133039 @default.
- W1976886090 creator A5038052110 @default.
- W1976886090 creator A5038825719 @default.
- W1976886090 creator A5054254227 @default.
- W1976886090 creator A5061466071 @default.
- W1976886090 creator A5062982950 @default.
- W1976886090 creator A5085749363 @default.
- W1976886090 creator A5090957403 @default.
- W1976886090 date "2014-04-04" @default.
- W1976886090 modified "2023-09-27" @default.
- W1976886090 title "Functional Modification of Drosophila Intestinal Stem Cells by Ionizing Radiation" @default.
- W1976886090 cites W1580804852 @default.
- W1976886090 cites W169445818 @default.
- W1976886090 cites W1967440011 @default.
- W1976886090 cites W1968814136 @default.
- W1976886090 cites W1973359552 @default.
- W1976886090 cites W1978143866 @default.
- W1976886090 cites W1978651716 @default.
- W1976886090 cites W1985234259 @default.
- W1976886090 cites W1986932941 @default.
- W1976886090 cites W1992336853 @default.
- W1976886090 cites W2001025011 @default.
- W1976886090 cites W2003388531 @default.
- W1976886090 cites W2006229889 @default.
- W1976886090 cites W2008484243 @default.
- W1976886090 cites W2025829112 @default.
- W1976886090 cites W2031217639 @default.
- W1976886090 cites W2035151165 @default.
- W1976886090 cites W2039652459 @default.
- W1976886090 cites W2042260470 @default.
- W1976886090 cites W2042686954 @default.
- W1976886090 cites W2051040012 @default.
- W1976886090 cites W2051909115 @default.
- W1976886090 cites W2052133467 @default.
- W1976886090 cites W2055301723 @default.
- W1976886090 cites W2056549202 @default.
- W1976886090 cites W2060558228 @default.
- W1976886090 cites W2065653828 @default.
- W1976886090 cites W2068121956 @default.
- W1976886090 cites W2068930946 @default.
- W1976886090 cites W2070386387 @default.
- W1976886090 cites W2073239066 @default.
- W1976886090 cites W2079657320 @default.
- W1976886090 cites W2088179903 @default.
- W1976886090 cites W2098137179 @default.
- W1976886090 cites W2105214962 @default.
- W1976886090 cites W2105575647 @default.
- W1976886090 cites W2106882281 @default.
- W1976886090 cites W2110367574 @default.
- W1976886090 cites W2114371575 @default.
- W1976886090 cites W2119092293 @default.
- W1976886090 cites W2128126810 @default.
- W1976886090 cites W2133745628 @default.
- W1976886090 cites W2142018200 @default.
- W1976886090 cites W2145200068 @default.
- W1976886090 cites W2145956680 @default.
- W1976886090 cites W2153718995 @default.
- W1976886090 cites W2155111434 @default.
- W1976886090 cites W2157285575 @default.
- W1976886090 cites W2162681116 @default.
- W1976886090 cites W2166053174 @default.
- W1976886090 cites W2170908574 @default.
- W1976886090 cites W2171278491 @default.
- W1976886090 cites W2174482320 @default.
- W1976886090 cites W22480690 @default.
- W1976886090 cites W2338715815 @default.
- W1976886090 doi "https://doi.org/10.1667/rr13545.1" @default.
- W1976886090 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24701963" @default.
- W1976886090 hasPublicationYear "2014" @default.
- W1976886090 type Work @default.
- W1976886090 sameAs 1976886090 @default.
- W1976886090 citedByCount "9" @default.
- W1976886090 countsByYear W19768860902015 @default.
- W1976886090 countsByYear W19768860902018 @default.
- W1976886090 countsByYear W19768860902020 @default.
- W1976886090 countsByYear W19768860902022 @default.
- W1976886090 crossrefType "journal-article" @default.
- W1976886090 hasAuthorship W1976886090A5021541241 @default.
- W1976886090 hasAuthorship W1976886090A5031356545 @default.
- W1976886090 hasAuthorship W1976886090A5037133039 @default.
- W1976886090 hasAuthorship W1976886090A5038052110 @default.
- W1976886090 hasAuthorship W1976886090A5038825719 @default.
- W1976886090 hasAuthorship W1976886090A5054254227 @default.
- W1976886090 hasAuthorship W1976886090A5061466071 @default.
- W1976886090 hasAuthorship W1976886090A5062982950 @default.
- W1976886090 hasAuthorship W1976886090A5085749363 @default.
- W1976886090 hasAuthorship W1976886090A5090957403 @default.
- W1976886090 hasConcept C111337013 @default.
- W1976886090 hasConcept C121332964 @default.
- W1976886090 hasConcept C150149183 @default.
- W1976886090 hasConcept C173758957 @default.
- W1976886090 hasConcept C18231593 @default.
- W1976886090 hasConcept C185544564 @default.
- W1976886090 hasConcept C28328180 @default.