Matches in SemOpenAlex for { <https://semopenalex.org/work/W1976891965> ?p ?o ?g. }
- W1976891965 endingPage "252" @default.
- W1976891965 startingPage "248" @default.
- W1976891965 abstract "β‐Amyloid precursor protein (APP) is a type I transmembrane protein. Its cleavages by β‐ and γ‐secretases yield β‐amyloid, which is the main constituent of senile plaques in Alzheimer's disease (AD). In apoptotic cells and AD brains, APP is alternatively cleaved by caspases in the cytoplasmic region after the Asp664 residue (with respect to the numbering conversion for the APP695 isoform). Caspase‐cleaved fragments of APP are cytotoxic and have been implicated in AD pathogenesis; however, the mechanisms regulating the cleavage have not been studied. APP is constitutively phosphorylated at Thr668 in brain. In the present study, we demonstrate that APP phosphorylated at Thr668 is less vulnerable to cytoplasmic cleavage by caspase‐3 and caspase‐8. This suggests that APP phosphorylation suppresses the generation of caspase‐cleaved fragments of APP in the brain and that perturbation of this phosphorylation may be involved in APP‐mediated neurotoxicity." @default.
- W1976891965 created "2016-06-24" @default.
- W1976891965 creator A5000893018 @default.
- W1976891965 creator A5040622924 @default.
- W1976891965 creator A5065167441 @default.
- W1976891965 date "2004-05-08" @default.
- W1976891965 modified "2023-10-14" @default.
- W1976891965 title "Suppression of the caspase cleavage of β-amyloid precursor protein by its cytoplasmic phosphorylation" @default.
- W1976891965 cites W1504283291 @default.
- W1976891965 cites W1527604508 @default.
- W1976891965 cites W1557927660 @default.
- W1976891965 cites W1571221506 @default.
- W1976891965 cites W1582490571 @default.
- W1976891965 cites W1587773919 @default.
- W1976891965 cites W1966241930 @default.
- W1976891965 cites W1966291495 @default.
- W1976891965 cites W1966655072 @default.
- W1976891965 cites W1973264518 @default.
- W1976891965 cites W1998626820 @default.
- W1976891965 cites W1999466646 @default.
- W1976891965 cites W2008747353 @default.
- W1976891965 cites W2028811730 @default.
- W1976891965 cites W2031565865 @default.
- W1976891965 cites W2034201162 @default.
- W1976891965 cites W2034614968 @default.
- W1976891965 cites W2041076714 @default.
- W1976891965 cites W2056510710 @default.
- W1976891965 cites W2057840062 @default.
- W1976891965 cites W2060677871 @default.
- W1976891965 cites W2064329399 @default.
- W1976891965 cites W2064470441 @default.
- W1976891965 cites W2065514845 @default.
- W1976891965 cites W2072372914 @default.
- W1976891965 cites W2075202596 @default.
- W1976891965 cites W2086747568 @default.
- W1976891965 cites W2090751165 @default.
- W1976891965 cites W2096410114 @default.
- W1976891965 cites W2136653849 @default.
- W1976891965 cites W2140347837 @default.
- W1976891965 cites W2149117501 @default.
- W1976891965 cites W2156179144 @default.
- W1976891965 doi "https://doi.org/10.1016/j.febslet.2004.04.077" @default.
- W1976891965 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15178331" @default.
- W1976891965 hasPublicationYear "2004" @default.
- W1976891965 type Work @default.
- W1976891965 sameAs 1976891965 @default.
- W1976891965 citedByCount "14" @default.
- W1976891965 countsByYear W19768919652012 @default.
- W1976891965 countsByYear W19768919652016 @default.
- W1976891965 countsByYear W19768919652022 @default.
- W1976891965 crossrefType "journal-article" @default.
- W1976891965 hasAuthorship W1976891965A5000893018 @default.
- W1976891965 hasAuthorship W1976891965A5040622924 @default.
- W1976891965 hasAuthorship W1976891965A5065167441 @default.
- W1976891965 hasConcept C11960822 @default.
- W1976891965 hasConcept C12519072 @default.
- W1976891965 hasConcept C126322002 @default.
- W1976891965 hasConcept C151730666 @default.
- W1976891965 hasConcept C170493617 @default.
- W1976891965 hasConcept C175156509 @default.
- W1976891965 hasConcept C177907266 @default.
- W1976891965 hasConcept C178790620 @default.
- W1976891965 hasConcept C180081513 @default.
- W1976891965 hasConcept C185592680 @default.
- W1976891965 hasConcept C190283241 @default.
- W1976891965 hasConcept C24530287 @default.
- W1976891965 hasConcept C2779134260 @default.
- W1976891965 hasConcept C2779491297 @default.
- W1976891965 hasConcept C29730261 @default.
- W1976891965 hasConcept C31573885 @default.
- W1976891965 hasConcept C31705614 @default.
- W1976891965 hasConcept C36103677 @default.
- W1976891965 hasConcept C41007966 @default.
- W1976891965 hasConcept C43369102 @default.
- W1976891965 hasConcept C502032728 @default.
- W1976891965 hasConcept C55493867 @default.
- W1976891965 hasConcept C68026918 @default.
- W1976891965 hasConcept C71924100 @default.
- W1976891965 hasConcept C86803240 @default.
- W1976891965 hasConcept C95444343 @default.
- W1976891965 hasConcept C98424977 @default.
- W1976891965 hasConceptScore W1976891965C11960822 @default.
- W1976891965 hasConceptScore W1976891965C12519072 @default.
- W1976891965 hasConceptScore W1976891965C126322002 @default.
- W1976891965 hasConceptScore W1976891965C151730666 @default.
- W1976891965 hasConceptScore W1976891965C170493617 @default.
- W1976891965 hasConceptScore W1976891965C175156509 @default.
- W1976891965 hasConceptScore W1976891965C177907266 @default.
- W1976891965 hasConceptScore W1976891965C178790620 @default.
- W1976891965 hasConceptScore W1976891965C180081513 @default.
- W1976891965 hasConceptScore W1976891965C185592680 @default.
- W1976891965 hasConceptScore W1976891965C190283241 @default.
- W1976891965 hasConceptScore W1976891965C24530287 @default.
- W1976891965 hasConceptScore W1976891965C2779134260 @default.
- W1976891965 hasConceptScore W1976891965C2779491297 @default.
- W1976891965 hasConceptScore W1976891965C29730261 @default.
- W1976891965 hasConceptScore W1976891965C31573885 @default.
- W1976891965 hasConceptScore W1976891965C31705614 @default.