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• W1976892589 abstract "Replacement of lost and/or dysfunctional astrocytes via multipotent neural stem cell (NSC) and lineage-restricted neural progenitor cell (NPC) transplantation is a promising therapeutic approach for traumatic spinal cord injury (SCI). Cell transplantation in general offers the potential to replace central nervous system (CNS) cell types, achieve remyelination, deliver missing gene products, promote and guide axonal growth, modulate the host immune response, deliver neuroprotective factors, and provide a cellular substrate for bridging the lesion site, amongst other possible benefits. A host of cell types that differ in their developmental stage, CNS region and species of derivation, as well as in their phenotypic potential, have been tested in a variety of SCI animal models. Historically in the SCI field, most pre-clinical NSC and NPC transplantation studies have focused on neuronal and oligodendrocyte replacement. However, much less attention has been geared towards targeting astroglial dysfunction in the inured spinal cord, despite the integral roles played by astrocytes in both normal CNS function and in the diseased nervous system. Despite the relative lack of studies, cell transplantation-based targeting of astrocytes dates back to some of the earliest transplant studies in SCI animal models. In this review, we will describe the history of work involving cell transplantation for targeting astrocytes in models of SCI. We will also touch on the current state of affairs in the field, as well as on important future directions as we move forward in trying to develop this approach into a viable strategy for SCI patients. Practical issues such as timing of delivery, route of transplantation and immunesuppression needs are beyond the scope of this review. This article is part of a Special Issue entitled SI: Spinal cord injury." @default.
• W1976892589 created "2016-06-24" @default.
• W1976892589 creator A5017100408 @default.
• W1976892589 creator A5019107444 @default.
• W1976892589 creator A5073463597 @default.
• W1976892589 date "2015-09-01" @default.
• W1976892589 modified "2023-10-10" @default.
• W1976892589 title "Therapeutically targeting astrocytes with stem and progenitor cell transplantation following traumatic spinal cord injury" @default.
• W1976892589 cites W1530199299 @default.
• W1976892589 cites W1531305298 @default.
• W1976892589 cites W1567844407 @default.
• W1976892589 cites W172954148 @default.
• W1976892589 cites W1928529925 @default.
• W1976892589 cites W1957468634 @default.
• W1976892589 cites W1969619562 @default.
• W1976892589 cites W1970345181 @default.
• W1976892589 cites W1973524445 @default.
• W1976892589 cites W1973972775 @default.
• W1976892589 cites W1975681168 @default.
• W1976892589 cites W1978120353 @default.
• W1976892589 cites W1979228875 @default.
• W1976892589 cites W1983273439 @default.
• W1976892589 cites W1987408946 @default.
• W1976892589 cites W1993629125 @default.
• W1976892589 cites W2001422973 @default.
• W1976892589 cites W2001706835 @default.
• W1976892589 cites W2002802452 @default.
• W1976892589 cites W2003037534 @default.
• W1976892589 cites W2004008188 @default.
• W1976892589 cites W2004041535 @default.
• W1976892589 cites W2006184315 @default.
• W1976892589 cites W2006289803 @default.
• W1976892589 cites W2009867508 @default.
• W1976892589 cites W2011343276 @default.
• W1976892589 cites W2011749979 @default.
• W1976892589 cites W2013779362 @default.
• W1976892589 cites W2017599428 @default.
• W1976892589 cites W2026411858 @default.
• W1976892589 cites W2031399191 @default.
• W1976892589 cites W2040022455 @default.
• W1976892589 cites W2050706464 @default.
• W1976892589 cites W2051094052 @default.
• W1976892589 cites W2051947267 @default.
• W1976892589 cites W2053878919 @default.
• W1976892589 cites W2054737835 @default.
• W1976892589 cites W2055162787 @default.
• W1976892589 cites W2056111826 @default.
• W1976892589 cites W2059172386 @default.
• W1976892589 cites W2063692247 @default.
• W1976892589 cites W2072278357 @default.
• W1976892589 cites W2073390876 @default.
• W1976892589 cites W2074661552 @default.
• W1976892589 cites W2076344617 @default.
• W1976892589 cites W2076367028 @default.
• W1976892589 cites W2079320514 @default.
• W1976892589 cites W2081176154 @default.
• W1976892589 cites W2082777494 @default.
• W1976892589 cites W2085424855 @default.
• W1976892589 cites W2089529899 @default.
• W1976892589 cites W2095225284 @default.
• W1976892589 cites W2097573610 @default.
• W1976892589 cites W2098622411 @default.
• W1976892589 cites W2101363175 @default.
• W1976892589 cites W2103275373 @default.
• W1976892589 cites W2104962692 @default.
• W1976892589 cites W2105302286 @default.
• W1976892589 cites W2107247710 @default.
• W1976892589 cites W2108301498 @default.
• W1976892589 cites W2115654652 @default.
• W1976892589 cites W2117526575 @default.
• W1976892589 cites W2123450039 @default.
• W1976892589 cites W2125900572 @default.
• W1976892589 cites W2128744963 @default.
• W1976892589 cites W2130020417 @default.
• W1976892589 cites W2134733089 @default.
• W1976892589 cites W2135376726 @default.
• W1976892589 cites W2136515772 @default.
• W1976892589 cites W2138832010 @default.
• W1976892589 cites W2144750363 @default.
• W1976892589 cites W2145586630 @default.
• W1976892589 cites W2148992136 @default.
• W1976892589 cites W2158626764 @default.
• W1976892589 cites W2311237560 @default.
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• W1976892589 doi "https://doi.org/10.1016/j.brainres.2014.09.037" @default.
• W1976892589 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4369470" @default.
• W1976892589 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25251595" @default.
• W1976892589 hasPublicationYear "2015" @default.
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