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• W1976894414 abstract "Effective drugs are urgently needed for the treatment of advanced neuroblastoma refractory to conventional chemotherapy. Pyrrolidine dithiocarbamate (PDTC) is a copper-binding ligand, which showed cytotoxicity on many human tumor cells after binding with copper ions. In this study, we synthesized a copper–PDTC complex, which was characterized as a Cu(PDTC)2 complex, with elemental analyses (Fourier transform infrared, electrospray ionization mass spectra, and ultraviolet-visible spectroscopy). The Cu(PDTC)2 complex suppressed the proliferation of BE(2)C cells, a human neuroblastoma cell line, with an IC50 of 8.0 μmol/l, which was more potent than cisplatin (IC50 of 80 μmol/l). Treatment of BE(2)C cells with the Cu(PDTC)2 complex caused the S-phase arrest of cell cycle progression, cellular apoptosis, and necrosis, and increased the expression of p53 protein. The Cu(PDTC)2 complex holds potential as a new drug for the treatment of refractory neuroblastoma in children." @default.
• W1976894414 created "2016-06-24" @default.
• W1976894414 creator A5019205260 @default.
• W1976894414 creator A5019571166 @default.
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• W1976894414 date "2008-02-01" @default.
• W1976894414 modified "2023-09-25" @default.
• W1976894414 title "Potent anticancer activity of pyrrolidine dithiocarbamate–copper complex against cisplatin-resistant neuroblastoma cells" @default.
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• W1976894414 doi "https://doi.org/10.1097/cad.0b013e3282f2bdff" @default.
• W1976894414 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18176108" @default.
• W1976894414 hasPublicationYear "2008" @default.
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