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- W1976902362 abstract "The genes encoding the rabbit 5HT1D alpha and 5HT1D beta receptors have been cloned. The deduced amino acid sequence of these receptors shows 91-92% amino acid sequence identity with their human homologues, and similar high sequence identity with homologues from other species. The receptors were transiently expressed in COS-7 cells and exhibit a pharmacological profile closely resembling their human homologues, including a higher affinity of ketanserin for the 5-HT1D alpha subtype. However, sumatriptan had a lower affinity for both the rabbit receptors compared to their human counterparts. This may be accounted for by differences between the primary amino acid sequences of these species homologues." @default.
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- W1976902362 date "1995-12-11" @default.
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- W1976902362 title "Cloning and characterisation of the rabbit 5-HT1Dα and 5-HT1Dβ receptors" @default.
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- W1976902362 doi "https://doi.org/10.1016/0014-5793(95)01308-3" @default.
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