FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1976906557> ?p ?o ?g. }

• W1976906557 endingPage "637" @default.
• W1976906557 startingPage "632" @default.
• W1976906557 abstract "A major role has been described for inducible nitric oxide (NO) synthase in several chronic inflammatory liver diseases. N-Acetyl-cysteine (NAC) is a sulfhydryl donor molecule with antioxidant and antiinflammatory effects. It attenuates NO generation following lipopolysaccharide injection in rats. Our goal was to study the effect of NAC on NO synthase induction in hepatocytes in response to proinflammatory cytokines.The effect of NAC on NO synthase induction was studied in the human hepatocyte cell lines HepG2 and 2.2.15 treated with a mixture of proinflammatory cytokines. Interactions between NAC and cytokines on nuclear factor-kappaB (NF-kappaB) activation and NO synthase promoter transactivation were investigated.NAC dose-dependently modulated the induction of NO synthase mRNA expression, the release of nitrites and the formation of NF-kappaB binding complexes in cytokine-treated hepatocytes. NAC also reduced the transactivation of the NO synthase promoter.Our data show that exposure of hepatocytes to NAC modulated NO synthase expression and NF-kappaB activity, the key responses of the hepatocyte to inflammatory mediators. These data constitute preliminary evidence that NAC might have hepatoprotective actions of potential relevance in chronic inflammatory liver diseases, mediated partially through the modulation of NO production." @default.
• W1976906557 created "2016-06-24" @default.
• W1976906557 creator A5001313354 @default.
• W1976906557 creator A5009504886 @default.
• W1976906557 creator A5022441204 @default.
• W1976906557 creator A5036568942 @default.
• W1976906557 creator A5054100257 @default.
• W1976906557 creator A5056007149 @default.
• W1976906557 creator A5072545657 @default.
• W1976906557 creator A5075485449 @default.
• W1976906557 date "2004-04-01" @default.
• W1976906557 modified "2023-10-18" @default.
• W1976906557 title "N-Acetyl-cysteine modulates inducible nitric oxide synthase gene expression in human hepatocytes" @default.
• W1976906557 cites W1495576061 @default.
• W1976906557 cites W1568529372 @default.
• W1976906557 cites W1591881963 @default.
• W1976906557 cites W1781350855 @default.
• W1976906557 cites W1976981858 @default.
• W1976906557 cites W1983588728 @default.
• W1976906557 cites W1984593535 @default.
• W1976906557 cites W1990606879 @default.
• W1976906557 cites W2006270258 @default.
• W1976906557 cites W2007437940 @default.
• W1976906557 cites W2007882007 @default.
• W1976906557 cites W2007888462 @default.
• W1976906557 cites W2008427962 @default.
• W1976906557 cites W2010338556 @default.
• W1976906557 cites W2014524132 @default.
• W1976906557 cites W2014916185 @default.
• W1976906557 cites W2019814232 @default.
• W1976906557 cites W2024897106 @default.
• W1976906557 cites W2026540294 @default.
• W1976906557 cites W2028501194 @default.
• W1976906557 cites W2031589215 @default.
• W1976906557 cites W2034751609 @default.
• W1976906557 cites W2055420058 @default.
• W1976906557 cites W2061126659 @default.
• W1976906557 cites W2062421510 @default.
• W1976906557 cites W2078338851 @default.
• W1976906557 cites W2095999646 @default.
• W1976906557 cites W2100286113 @default.
• W1976906557 cites W2121282237 @default.
• W1976906557 cites W2128925357 @default.
• W1976906557 cites W2137175764 @default.
• W1976906557 cites W2151892297 @default.
• W1976906557 cites W2158118222 @default.
• W1976906557 cites W2166781237 @default.
• W1976906557 cites W2187771220 @default.
• W1976906557 cites W2204123985 @default.
• W1976906557 doi "https://doi.org/10.1016/j.jhep.2003.12.009" @default.
• W1976906557 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15030979" @default.
• W1976906557 hasPublicationYear "2004" @default.
• W1976906557 type Work @default.
• W1976906557 sameAs 1976906557 @default.
• W1976906557 citedByCount "59" @default.
• W1976906557 countsByYear W19769065572012 @default.
• W1976906557 countsByYear W19769065572013 @default.
• W1976906557 countsByYear W19769065572014 @default.
• W1976906557 countsByYear W19769065572015 @default.
• W1976906557 countsByYear W19769065572016 @default.
• W1976906557 countsByYear W19769065572017 @default.
• W1976906557 countsByYear W19769065572019 @default.
• W1976906557 countsByYear W19769065572020 @default.
• W1976906557 countsByYear W19769065572021 @default.
• W1976906557 countsByYear W19769065572022 @default.
• W1976906557 crossrefType "journal-article" @default.
• W1976906557 hasAuthorship W1976906557A5001313354 @default.
• W1976906557 hasAuthorship W1976906557A5009504886 @default.
• W1976906557 hasAuthorship W1976906557A5022441204 @default.
• W1976906557 hasAuthorship W1976906557A5036568942 @default.
• W1976906557 hasAuthorship W1976906557A5054100257 @default.
• W1976906557 hasAuthorship W1976906557A5056007149 @default.
• W1976906557 hasAuthorship W1976906557A5072545657 @default.
• W1976906557 hasAuthorship W1976906557A5075485449 @default.
• W1976906557 hasConcept C104317684 @default.
• W1976906557 hasConcept C112243037 @default.
• W1976906557 hasConcept C1292079 @default.
• W1976906557 hasConcept C150194340 @default.
• W1976906557 hasConcept C153911025 @default.
• W1976906557 hasConcept C164027704 @default.
• W1976906557 hasConcept C181199279 @default.
• W1976906557 hasConcept C185592680 @default.
• W1976906557 hasConcept C202751555 @default.
• W1976906557 hasConcept C203014093 @default.
• W1976906557 hasConcept C2776200302 @default.
• W1976906557 hasConcept C2776914184 @default.
• W1976906557 hasConcept C2777622882 @default.
• W1976906557 hasConcept C55493867 @default.
• W1976906557 hasConcept C86803240 @default.
• W1976906557 hasConceptScore W1976906557C104317684 @default.
• W1976906557 hasConceptScore W1976906557C112243037 @default.
• W1976906557 hasConceptScore W1976906557C1292079 @default.
• W1976906557 hasConceptScore W1976906557C150194340 @default.
• W1976906557 hasConceptScore W1976906557C153911025 @default.
• W1976906557 hasConceptScore W1976906557C164027704 @default.
• W1976906557 hasConceptScore W1976906557C181199279 @default.
• W1976906557 hasConceptScore W1976906557C185592680 @default.
• W1976906557 hasConceptScore W1976906557C202751555 @default.

• next