Matches in SemOpenAlex for { <https://semopenalex.org/work/W1976913106> ?p ?o ?g. }
Showing items 1 to 82 of
82
with 100 items per page.
- W1976913106 endingPage "303" @default.
- W1976913106 startingPage "297" @default.
- W1976913106 abstract "Transport characteristics of grepafloxacin and levofloxacin across the apical membrane of Caco-2 cells were examined. Both grepafloxacin and levofloxacin uptakes increased rapidly, and were temperature-dependent. Grepafloxacin and levofloxacin uptakes showed concentration-dependent saturation with Michaelis constants of 3.9 and 9.3 mM, respectively. Uptake of grepafloxacin and levofloxacin increased in Cl(-)-free and ATP depleted conditions, suggesting the involvement of an efflux transport system different from the uptake mechanism. However, cyclosporin A, a typical inhibitor of P-glycoprotein, did not affect the uptake of these drugs. Unlabeled grepafloxacin, unlabeled levofloxacin and quinidine inhibited the uptake of grepafloxacin and levofloxacin under Cl(-)-free conditions. Tetraethylammonium, cimetidine, p-aminohippurate, probenecid, amino acids, beta-lactam antibiotic or monocarboxylates did not inhibit the uptake of grepafloxacin and levofloxacin under the same conditions. In conclusion, our results suggested that grepafloxacin and levofloxacin uptakes were mediated by a specific transport system distinct from those for organic cations and anions, amino acids, dipeptides and monocarboxylates." @default.
- W1976913106 created "2016-06-24" @default.
- W1976913106 creator A5010169211 @default.
- W1976913106 creator A5022145747 @default.
- W1976913106 creator A5039137137 @default.
- W1976913106 creator A5059944980 @default.
- W1976913106 date "2001-11-01" @default.
- W1976913106 modified "2023-10-04" @default.
- W1976913106 title "Transport characteristics of grepafloxacin and levofloxacin in the human intestinal cell line Caco-2" @default.
- W1976913106 cites W158950312 @default.
- W1976913106 cites W1628890212 @default.
- W1976913106 cites W169609578 @default.
- W1976913106 cites W1838741822 @default.
- W1976913106 cites W1904678284 @default.
- W1976913106 cites W1962928558 @default.
- W1976913106 cites W1979109090 @default.
- W1976913106 cites W1988629728 @default.
- W1976913106 cites W1993175289 @default.
- W1976913106 cites W2005062381 @default.
- W1976913106 cites W2010485761 @default.
- W1976913106 cites W2023354362 @default.
- W1976913106 cites W2048394150 @default.
- W1976913106 cites W2064618798 @default.
- W1976913106 cites W2123518254 @default.
- W1976913106 cites W2135152819 @default.
- W1976913106 cites W2150311520 @default.
- W1976913106 cites W297511950 @default.
- W1976913106 cites W4293247451 @default.
- W1976913106 doi "https://doi.org/10.1016/s0014-2999(01)01448-0" @default.
- W1976913106 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11730721" @default.
- W1976913106 hasPublicationYear "2001" @default.
- W1976913106 type Work @default.
- W1976913106 sameAs 1976913106 @default.
- W1976913106 citedByCount "34" @default.
- W1976913106 countsByYear W19769131062012 @default.
- W1976913106 countsByYear W19769131062015 @default.
- W1976913106 countsByYear W19769131062019 @default.
- W1976913106 countsByYear W19769131062023 @default.
- W1976913106 crossrefType "journal-article" @default.
- W1976913106 hasAuthorship W1976913106A5010169211 @default.
- W1976913106 hasAuthorship W1976913106A5022145747 @default.
- W1976913106 hasAuthorship W1976913106A5039137137 @default.
- W1976913106 hasAuthorship W1976913106A5059944980 @default.
- W1976913106 hasConcept C185592680 @default.
- W1976913106 hasConcept C200082930 @default.
- W1976913106 hasConcept C2776769776 @default.
- W1976913106 hasConcept C2781276175 @default.
- W1976913106 hasConcept C501593827 @default.
- W1976913106 hasConcept C55493867 @default.
- W1976913106 hasConcept C71924100 @default.
- W1976913106 hasConcept C98274493 @default.
- W1976913106 hasConceptScore W1976913106C185592680 @default.
- W1976913106 hasConceptScore W1976913106C200082930 @default.
- W1976913106 hasConceptScore W1976913106C2776769776 @default.
- W1976913106 hasConceptScore W1976913106C2781276175 @default.
- W1976913106 hasConceptScore W1976913106C501593827 @default.
- W1976913106 hasConceptScore W1976913106C55493867 @default.
- W1976913106 hasConceptScore W1976913106C71924100 @default.
- W1976913106 hasConceptScore W1976913106C98274493 @default.
- W1976913106 hasFunder F4320320912 @default.
- W1976913106 hasIssue "3" @default.
- W1976913106 hasLocation W19769131061 @default.
- W1976913106 hasLocation W19769131062 @default.
- W1976913106 hasOpenAccess W1976913106 @default.
- W1976913106 hasPrimaryLocation W19769131061 @default.
- W1976913106 hasRelatedWork W1579027806 @default.
- W1976913106 hasRelatedWork W1976913106 @default.
- W1976913106 hasRelatedWork W2011560794 @default.
- W1976913106 hasRelatedWork W2099145359 @default.
- W1976913106 hasRelatedWork W2128736157 @default.
- W1976913106 hasRelatedWork W2168381076 @default.
- W1976913106 hasRelatedWork W2375008532 @default.
- W1976913106 hasRelatedWork W3151508073 @default.
- W1976913106 hasRelatedWork W4306671884 @default.
- W1976913106 hasRelatedWork W566138763 @default.
- W1976913106 hasVolume "431" @default.
- W1976913106 isParatext "false" @default.
- W1976913106 isRetracted "false" @default.
- W1976913106 magId "1976913106" @default.
- W1976913106 workType "article" @default.