Matches in SemOpenAlex for { <https://semopenalex.org/work/W1976916938> ?p ?o ?g. }
- W1976916938 endingPage "196" @default.
- W1976916938 startingPage "184" @default.
- W1976916938 abstract "A computational model of the organ of Corti is described to assist in the interpretation of electrophysiological data concerning the role of the K+ channels residing in the basolateral membrane of cochlear hair cells. Recent in vivo data from Van Emst et al. (Hear. Res. 88, 27–35 (1995); Hear. Res. 102, 70–80 (1996)) about the effects of selective blocking of K+ channels indicate that these channels affect the magnitude of the summating potential. In order to understand the nature of this effect, the model of Dallos (Hear. Res. 14, 281–291 (1984)) was extended to account for the voltage- and time-dependent properties of the K+ channels in the basolateral membrane of the inner hair cell (IHC) (Kros and Crawford, J. Physiol. 421, 262–291 (1990)). The model shows that the K+ channels induce a shift in the mean IHC basolateral conductance when high-frequency stimuli are present. As a result, cochlear transduction shifts to a different electrical operating state and this is the source of a marked decrease in the stimulus-evoked DC response of the IHC. Extracellularly, in contrast, the magnitude of the DC response increases slightly. At low frequencies, the K+ channels respond to the stimulus waveform on a cycle-by-cycle basis. The waveform distortion associated with this dynamic basolateral impedance induces a further decrease in the intracellular stimulus-evoked DC response of the IHC. Thus, K+ channels in the IHC appear to be directly involved in the generation of the DC receptor potential at low frequencies, but at high frequencies they simply modify the size of the DC response." @default.
- W1976916938 created "2016-06-24" @default.
- W1976916938 creator A5056430404 @default.
- W1976916938 creator A5058615575 @default.
- W1976916938 creator A5069056909 @default.
- W1976916938 date "1998-01-01" @default.
- W1976916938 modified "2023-10-03" @default.
- W1976916938 title "The generation of DC potentials in a computational model of the organ of Corti: effects of voltage-dependent K+ channels in the basolateral membrane of the inner hair cell" @default.
- W1976916938 cites W1522557328 @default.
- W1976916938 cites W1534748065 @default.
- W1976916938 cites W1554225425 @default.
- W1976916938 cites W1961010007 @default.
- W1976916938 cites W1968603844 @default.
- W1976916938 cites W1972580129 @default.
- W1976916938 cites W1975610963 @default.
- W1976916938 cites W1988508433 @default.
- W1976916938 cites W1990717776 @default.
- W1976916938 cites W1993286335 @default.
- W1976916938 cites W2013534687 @default.
- W1976916938 cites W2018408627 @default.
- W1976916938 cites W2029715006 @default.
- W1976916938 cites W2031581165 @default.
- W1976916938 cites W2036557766 @default.
- W1976916938 cites W2039210522 @default.
- W1976916938 cites W2039511769 @default.
- W1976916938 cites W2041351498 @default.
- W1976916938 cites W2043110630 @default.
- W1976916938 cites W2048124418 @default.
- W1976916938 cites W2058178851 @default.
- W1976916938 cites W2064129017 @default.
- W1976916938 cites W2081439231 @default.
- W1976916938 cites W2089519873 @default.
- W1976916938 cites W2104292356 @default.
- W1976916938 cites W2106127058 @default.
- W1976916938 cites W2114696865 @default.
- W1976916938 cites W4234299024 @default.
- W1976916938 doi "https://doi.org/10.1016/s0378-5955(97)00192-5" @default.
- W1976916938 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9472747" @default.
- W1976916938 hasPublicationYear "1998" @default.
- W1976916938 type Work @default.
- W1976916938 sameAs 1976916938 @default.
- W1976916938 citedByCount "7" @default.
- W1976916938 countsByYear W19769169382019 @default.
- W1976916938 crossrefType "journal-article" @default.
- W1976916938 hasAuthorship W1976916938A5056430404 @default.
- W1976916938 hasAuthorship W1976916938A5058615575 @default.
- W1976916938 hasAuthorship W1976916938A5069056909 @default.
- W1976916938 hasConcept C12554922 @default.
- W1976916938 hasConcept C15744967 @default.
- W1976916938 hasConcept C169760540 @default.
- W1976916938 hasConcept C170493617 @default.
- W1976916938 hasConcept C181911157 @default.
- W1976916938 hasConcept C185263204 @default.
- W1976916938 hasConcept C185592680 @default.
- W1976916938 hasConcept C2778500370 @default.
- W1976916938 hasConcept C2778585322 @default.
- W1976916938 hasConcept C2779918689 @default.
- W1976916938 hasConcept C2780130748 @default.
- W1976916938 hasConcept C2780659331 @default.
- W1976916938 hasConcept C2780807236 @default.
- W1976916938 hasConcept C39587587 @default.
- W1976916938 hasConcept C41625074 @default.
- W1976916938 hasConcept C542102704 @default.
- W1976916938 hasConcept C55493867 @default.
- W1976916938 hasConcept C86803240 @default.
- W1976916938 hasConcept C88367079 @default.
- W1976916938 hasConceptScore W1976916938C12554922 @default.
- W1976916938 hasConceptScore W1976916938C15744967 @default.
- W1976916938 hasConceptScore W1976916938C169760540 @default.
- W1976916938 hasConceptScore W1976916938C170493617 @default.
- W1976916938 hasConceptScore W1976916938C181911157 @default.
- W1976916938 hasConceptScore W1976916938C185263204 @default.
- W1976916938 hasConceptScore W1976916938C185592680 @default.
- W1976916938 hasConceptScore W1976916938C2778500370 @default.
- W1976916938 hasConceptScore W1976916938C2778585322 @default.
- W1976916938 hasConceptScore W1976916938C2779918689 @default.
- W1976916938 hasConceptScore W1976916938C2780130748 @default.
- W1976916938 hasConceptScore W1976916938C2780659331 @default.
- W1976916938 hasConceptScore W1976916938C2780807236 @default.
- W1976916938 hasConceptScore W1976916938C39587587 @default.
- W1976916938 hasConceptScore W1976916938C41625074 @default.
- W1976916938 hasConceptScore W1976916938C542102704 @default.
- W1976916938 hasConceptScore W1976916938C55493867 @default.
- W1976916938 hasConceptScore W1976916938C86803240 @default.
- W1976916938 hasConceptScore W1976916938C88367079 @default.
- W1976916938 hasIssue "1-2" @default.
- W1976916938 hasLocation W19769169381 @default.
- W1976916938 hasLocation W19769169382 @default.
- W1976916938 hasOpenAccess W1976916938 @default.
- W1976916938 hasPrimaryLocation W19769169381 @default.
- W1976916938 hasRelatedWork W1975610963 @default.
- W1976916938 hasRelatedWork W1976916938 @default.
- W1976916938 hasRelatedWork W1989902389 @default.
- W1976916938 hasRelatedWork W2004128608 @default.
- W1976916938 hasRelatedWork W2036288638 @default.
- W1976916938 hasRelatedWork W2043819488 @default.
- W1976916938 hasRelatedWork W2064852921 @default.
- W1976916938 hasRelatedWork W2074107115 @default.