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- W1976926134 abstract "Hyperparathyroidism and its related symptoms such as bone pain, soft-tissue calcifications and pruritus often get worse during dialysis treatment. We have treated 12 cases among 170 patients on regular dialysis by using coated charcoal (150 g/cartridge) in combination with standard hemodialysis. During a 6-month treatment period, without changing medical therapy and diet regime, the patients reported a marked relief from pruritus. Parathyroid hormone (PTH) levels changed from 552 ± 86 to 364 ± 62 pg/ml (p < 0.001) compared to the pretreatment period, Plasma PO34 changed in the same period from 6.9 ± 1.8 to 4.6 ± 1.5 mg/dl (p < 0.005). The results obtained indicate a relationship between PTH, serum plasma PO34- levels and pruritus. The mechanism which may be involved is that hemoperfusion removes PTH excess by absorption. Our treatment reducing PTH levels resulted in a marked relief from pruritus and other symptoms, suggesting that patients in this condition, before undergoing surgical parathyroidectomy, may be usefully treated with this therapeutic modality." @default.
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- W1976926134 date "1991-01-01" @default.
- W1976926134 modified "2023-10-11" @default.
- W1976926134 title "Combined Hemodialysis-Hemoperfusion in the Treatment of Secondary Hyperparathyroidism of Uremic Patients" @default.
- W1976926134 doi "https://doi.org/10.1159/000170011" @default.
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