Matches in SemOpenAlex for { <https://semopenalex.org/work/W1976943279> ?p ?o ?g. }
- W1976943279 endingPage "1212" @default.
- W1976943279 startingPage "1207" @default.
- W1976943279 abstract "Generation of left-right asymmetry is an integral part of the establishment of the vertebrate body plan. Here we show that the Notch signaling pathway plays a primary role in the establishment of left-right asymmetry in mice by directly regulating expression of the Nodal gene. Embryos mutant for the Notch ligand Dll1 or doubly mutant for the Notch1 and Notch2 receptors exhibit multiple defects in left-right asymmetry. Analysis of the enhancer regulating node-specific Nodal expression revealed the presence of binding sites for the RBP-J protein, the primary transcriptional mediator of Notch signaling. Mutation of these sites destroyed the ability of this enhancer to direct node-specific gene expression in transgenic mice. Our results demonstrate that Dll1-mediated Notch signaling is essential for generation of left-right asymmetry, and that the Notch pathway acts upstream of Nodal expression during left-right asymmetry determination in mice." @default.
- W1976943279 created "2016-06-24" @default.
- W1976943279 creator A5008808387 @default.
- W1976943279 creator A5019190546 @default.
- W1976943279 creator A5021230471 @default.
- W1976943279 creator A5039090244 @default.
- W1976943279 creator A5039480088 @default.
- W1976943279 creator A5042544285 @default.
- W1976943279 creator A5050198479 @default.
- W1976943279 creator A5053775618 @default.
- W1976943279 creator A5054556673 @default.
- W1976943279 creator A5069070342 @default.
- W1976943279 date "2003-05-02" @default.
- W1976943279 modified "2023-10-08" @default.
- W1976943279 title "Notch signaling regulates left–right asymmetry determination by inducing<i>Nodal</i>expression" @default.
- W1976943279 cites W1491063745 @default.
- W1976943279 cites W1560909626 @default.
- W1976943279 cites W1905183026 @default.
- W1976943279 cites W1949779925 @default.
- W1976943279 cites W1965047305 @default.
- W1976943279 cites W1966616677 @default.
- W1976943279 cites W1976354992 @default.
- W1976943279 cites W1977253322 @default.
- W1976943279 cites W2004211510 @default.
- W1976943279 cites W2005901261 @default.
- W1976943279 cites W2016882805 @default.
- W1976943279 cites W2021705484 @default.
- W1976943279 cites W2023768613 @default.
- W1976943279 cites W2029279705 @default.
- W1976943279 cites W2029358883 @default.
- W1976943279 cites W2046039219 @default.
- W1976943279 cites W2047604499 @default.
- W1976943279 cites W2056824123 @default.
- W1976943279 cites W2073264990 @default.
- W1976943279 cites W2074950512 @default.
- W1976943279 cites W2079385288 @default.
- W1976943279 cites W2083664734 @default.
- W1976943279 cites W2083904901 @default.
- W1976943279 cites W2084105838 @default.
- W1976943279 cites W2086768503 @default.
- W1976943279 cites W2092178332 @default.
- W1976943279 cites W2094474152 @default.
- W1976943279 cites W2094686345 @default.
- W1976943279 cites W2095666604 @default.
- W1976943279 cites W2099023864 @default.
- W1976943279 cites W2099094757 @default.
- W1976943279 cites W2106384420 @default.
- W1976943279 cites W2115680883 @default.
- W1976943279 cites W2120936186 @default.
- W1976943279 cites W2125720034 @default.
- W1976943279 cites W2133859473 @default.
- W1976943279 cites W2136704564 @default.
- W1976943279 cites W2140553945 @default.
- W1976943279 cites W2145832243 @default.
- W1976943279 cites W2154861644 @default.
- W1976943279 cites W2162275131 @default.
- W1976943279 cites W2167582537 @default.
- W1976943279 doi "https://doi.org/10.1101/gad.1084703" @default.
- W1976943279 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/196059" @default.
- W1976943279 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12730124" @default.
- W1976943279 hasPublicationYear "2003" @default.
- W1976943279 type Work @default.
- W1976943279 sameAs 1976943279 @default.
- W1976943279 citedByCount "214" @default.
- W1976943279 countsByYear W19769432792012 @default.
- W1976943279 countsByYear W19769432792013 @default.
- W1976943279 countsByYear W19769432792014 @default.
- W1976943279 countsByYear W19769432792015 @default.
- W1976943279 countsByYear W19769432792016 @default.
- W1976943279 countsByYear W19769432792017 @default.
- W1976943279 countsByYear W19769432792018 @default.
- W1976943279 countsByYear W19769432792019 @default.
- W1976943279 countsByYear W19769432792020 @default.
- W1976943279 countsByYear W19769432792021 @default.
- W1976943279 countsByYear W19769432792022 @default.
- W1976943279 countsByYear W19769432792023 @default.
- W1976943279 crossrefType "journal-article" @default.
- W1976943279 hasAuthorship W1976943279A5008808387 @default.
- W1976943279 hasAuthorship W1976943279A5019190546 @default.
- W1976943279 hasAuthorship W1976943279A5021230471 @default.
- W1976943279 hasAuthorship W1976943279A5039090244 @default.
- W1976943279 hasAuthorship W1976943279A5039480088 @default.
- W1976943279 hasAuthorship W1976943279A5042544285 @default.
- W1976943279 hasAuthorship W1976943279A5050198479 @default.
- W1976943279 hasAuthorship W1976943279A5053775618 @default.
- W1976943279 hasAuthorship W1976943279A5054556673 @default.
- W1976943279 hasAuthorship W1976943279A5069070342 @default.
- W1976943279 hasBestOaLocation W19769432791 @default.
- W1976943279 hasConcept C102230213 @default.
- W1976943279 hasConcept C104317684 @default.
- W1976943279 hasConcept C111936080 @default.
- W1976943279 hasConcept C129536746 @default.
- W1976943279 hasConcept C143065580 @default.
- W1976943279 hasConcept C145103041 @default.
- W1976943279 hasConcept C150194340 @default.
- W1976943279 hasConcept C161879069 @default.
- W1976943279 hasConcept C165864922 @default.
- W1976943279 hasConcept C202769670 @default.