FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1976943931> ?p ?o ?g. }

• W1976943931 endingPage "75" @default.
• W1976943931 startingPage "69" @default.
• W1976943931 abstract "Low bone mineral density (BMD) is a risk factor for osteoporosis. Osteoporosis is more prevalent in females than in males. So far, the pathophysiological mechanisms underlying osteoporosis are unclear. Peripheral blood monocytes (PBMs) are precursors of bone-resorbing osteoclasts. This study aims to identify PBM-expressed proteins (genes) influencing hip BMD in humans. We utilized three independent study cohorts (N=34, 29, 40), including premenopausal Caucasians with discordant hip BMD. We studied PBM proteome-wide protein expression profiles in cohort 1 and identified 57 differentially expressed proteins (DEPs) between low vs. high BMD subjects. One protein gelsolin (GSN), after validation by Western blotting, was subject to follow-up. We compared GSN mRNA level in PBM between low vs. high BMD subjects in cohorts 2 and 3. We genotyped SNPs across GSN in 2286 unrelated Caucasians (cohort 4) and 1627 Chinese (cohort 5) and tested their association with hip BMD in females and males, respectively. We discovered and validated that GSN protein expression level in PBM was down-regulated 3.0-fold in low vs. high BMD subjects (P<0.05). Down-regulation of GSN in PBM in low BMD subjects was also observed at mRNA level in both cohort 2 and cohort 3. We identified that SNP rs767770 was significantly associated with hip BMD in female Caucasians (P=0.0003) only. Integrating analyses of the datasets at DNA, RNA, and protein levels from female Caucasians substantiated that GSN is highly significant for hip BMD (P=0.0001). We conclude that GSN is a significant gene influencing hip BMD in female Caucasians." @default.
• W1976943931 created "2016-06-24" @default.
• W1976943931 creator A5006738993 @default.
• W1976943931 creator A5014154811 @default.
• W1976943931 creator A5025460672 @default.
• W1976943931 creator A5026672460 @default.
• W1976943931 creator A5030950854 @default.
• W1976943931 creator A5055342281 @default.
• W1976943931 creator A5060423640 @default.
• W1976943931 creator A5072824384 @default.
• W1976943931 creator A5078672664 @default.
• W1976943931 date "2014-06-01" @default.
• W1976943931 modified "2023-10-16" @default.
• W1976943931 title "Is GSN significant for hip BMD in female Caucasians?" @default.
• W1976943931 cites W1584781794 @default.
• W1976943931 cites W178768211 @default.
• W1976943931 cites W1965283193 @default.
• W1976943931 cites W1967502057 @default.
• W1976943931 cites W1967938287 @default.
• W1976943931 cites W1970741710 @default.
• W1976943931 cites W1971960644 @default.
• W1976943931 cites W1975244016 @default.
• W1976943931 cites W1986887325 @default.
• W1976943931 cites W1988413265 @default.
• W1976943931 cites W1994849711 @default.
• W1976943931 cites W2002155339 @default.
• W1976943931 cites W2007589116 @default.
• W1976943931 cites W2017347652 @default.
• W1976943931 cites W2022315433 @default.
• W1976943931 cites W2025233865 @default.
• W1976943931 cites W2028355948 @default.
• W1976943931 cites W2033835546 @default.
• W1976943931 cites W2033864326 @default.
• W1976943931 cites W2037151103 @default.
• W1976943931 cites W2041154768 @default.
• W1976943931 cites W2044482752 @default.
• W1976943931 cites W2046718661 @default.
• W1976943931 cites W2049135171 @default.
• W1976943931 cites W2050602600 @default.
• W1976943931 cites W2056885783 @default.
• W1976943931 cites W2057570836 @default.
• W1976943931 cites W2066813035 @default.
• W1976943931 cites W2070665737 @default.
• W1976943931 cites W2074061365 @default.
• W1976943931 cites W2074640104 @default.
• W1976943931 cites W2084974619 @default.
• W1976943931 cites W2085675651 @default.
• W1976943931 cites W2087433310 @default.
• W1976943931 cites W2093252878 @default.
• W1976943931 cites W2106571316 @default.
• W1976943931 cites W2110993073 @default.
• W1976943931 cites W2123180563 @default.
• W1976943931 cites W2123939146 @default.
• W1976943931 cites W2126017970 @default.
• W1976943931 cites W2137106918 @default.
• W1976943931 cites W2150752239 @default.
• W1976943931 cites W2157752701 @default.
• W1976943931 cites W2164472870 @default.
• W1976943931 cites W2170989872 @default.
• W1976943931 cites W2417547881 @default.
• W1976943931 cites W3021121462 @default.
• W1976943931 doi "https://doi.org/10.1016/j.bone.2014.02.015" @default.
• W1976943931 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4127973" @default.
• W1976943931 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24607942" @default.
• W1976943931 hasPublicationYear "2014" @default.
• W1976943931 type Work @default.
• W1976943931 sameAs 1976943931 @default.
• W1976943931 citedByCount "17" @default.
• W1976943931 countsByYear W19769439312015 @default.
• W1976943931 countsByYear W19769439312016 @default.
• W1976943931 countsByYear W19769439312018 @default.
• W1976943931 countsByYear W19769439312019 @default.
• W1976943931 countsByYear W19769439312020 @default.
• W1976943931 countsByYear W19769439312022 @default.
• W1976943931 crossrefType "journal-article" @default.
• W1976943931 hasAuthorship W1976943931A5006738993 @default.
• W1976943931 hasAuthorship W1976943931A5014154811 @default.
• W1976943931 hasAuthorship W1976943931A5025460672 @default.
• W1976943931 hasAuthorship W1976943931A5026672460 @default.
• W1976943931 hasAuthorship W1976943931A5030950854 @default.
• W1976943931 hasAuthorship W1976943931A5055342281 @default.
• W1976943931 hasAuthorship W1976943931A5060423640 @default.
• W1976943931 hasAuthorship W1976943931A5072824384 @default.
• W1976943931 hasAuthorship W1976943931A5078672664 @default.
• W1976943931 hasBestOaLocation W19769439312 @default.
• W1976943931 hasConcept C104317684 @default.
• W1976943931 hasConcept C125705527 @default.
• W1976943931 hasConcept C126322002 @default.
• W1976943931 hasConcept C134018914 @default.
• W1976943931 hasConcept C135763542 @default.
• W1976943931 hasConcept C153209595 @default.
• W1976943931 hasConcept C201903717 @default.
• W1976943931 hasConcept C2776541429 @default.
• W1976943931 hasConcept C2776886416 @default.
• W1976943931 hasConcept C42407357 @default.
• W1976943931 hasConcept C54355233 @default.
• W1976943931 hasConcept C71924100 @default.
• W1976943931 hasConcept C72563966 @default.

• next