FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1976948995> ?p ?o ?g. }

• W1976948995 endingPage "301" @default.
• W1976948995 startingPage "291" @default.
• W1976948995 abstract "We have investigated several aspects of the complex sequence of events, transmitting the antigen-induced signal of cross-linking immunoglobulin E (IgE) resident in the membrane surface of mast cells into the signals yielding the final process of mediator release. Already the initial phase of this cascade still requires a better understanding. Namely, we are still missing a clear physical description of the effective stimulus- producing antigen-IgE complex in terms of size and spatial requirements. We are investigating this problem on a well-defined cell line (rat basophihe leukemia-RBL-2H3) using synthetic divalent haptens and a monoclonal IgE. A subsequent phase following IgE aggregation is a transient increase in the free calcium concentration in these cells' cytosol. The source of the Ca2+ and the way by which it enters the cytosol are studied predominantly by examining antigen-induced channel activity in the cells' membrane allowing Ca2+ influx from the exterior medium. Finally, we have observed that under certain experimental conditions, antigen-induced degranulation can be achieved even without a rise in cytosolic free calcium. In our search for alternative second messengers, we examine the potential candidacy of the cytosolic Na+/H+ balance. So far, we have found that antigen-stimulated secretion does require extracelular sodium and involves changes in its cytosolic pH. However, further studies are required to clarify its possible role as a coupling element." @default.
• W1976948995 created "2016-06-24" @default.
• W1976948995 creator A5011898281 @default.
• W1976948995 creator A5021244474 @default.
• W1976948995 date "1987-05-01" @default.
• W1976948995 modified "2023-09-25" @default.
• W1976948995 title "Stimulus-secretion coupling mechanisms in mast cells" @default.
• W1976948995 cites W11976976 @default.
• W1976948995 cites W1513787713 @default.
• W1976948995 cites W1521719412 @default.
• W1976948995 cites W1527715380 @default.
• W1976948995 cites W1563014186 @default.
• W1976948995 cites W1603010024 @default.
• W1976948995 cites W1750204594 @default.
• W1976948995 cites W1913357042 @default.
• W1976948995 cites W1964839077 @default.
• W1976948995 cites W1966724400 @default.
• W1976948995 cites W1985500682 @default.
• W1976948995 cites W1996755579 @default.
• W1976948995 cites W2005667409 @default.
• W1976948995 cites W2005820308 @default.
• W1976948995 cites W2016701351 @default.
• W1976948995 cites W2039634043 @default.
• W1976948995 cites W2047897111 @default.
• W1976948995 cites W2067172371 @default.
• W1976948995 cites W2068424781 @default.
• W1976948995 cites W2068877244 @default.
• W1976948995 cites W2085669875 @default.
• W1976948995 cites W2094053971 @default.
• W1976948995 cites W2099424253 @default.
• W1976948995 cites W2106973449 @default.
• W1976948995 cites W2110354487 @default.
• W1976948995 cites W2133252543 @default.
• W1976948995 cites W2140152586 @default.
• W1976948995 cites W2174107598 @default.
• W1976948995 cites W309625425 @default.
• W1976948995 cites W36684287 @default.
• W1976948995 cites W4237593635 @default.
• W1976948995 cites W4238605098 @default.
• W1976948995 doi "https://doi.org/10.1016/0301-4622(87)80030-3" @default.
• W1976948995 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/3607230" @default.
• W1976948995 hasPublicationYear "1987" @default.
• W1976948995 type Work @default.
• W1976948995 sameAs 1976948995 @default.
• W1976948995 citedByCount "7" @default.
• W1976948995 countsByYear W19769489952012 @default.
• W1976948995 countsByYear W19769489952015 @default.
• W1976948995 crossrefType "journal-article" @default.
• W1976948995 hasAuthorship W1976948995A5011898281 @default.
• W1976948995 hasAuthorship W1976948995A5021244474 @default.
• W1976948995 hasConcept C12554922 @default.
• W1976948995 hasConcept C141105273 @default.
• W1976948995 hasConcept C147483822 @default.
• W1976948995 hasConcept C159654299 @default.
• W1976948995 hasConcept C170493617 @default.
• W1976948995 hasConcept C178790620 @default.
• W1976948995 hasConcept C181199279 @default.
• W1976948995 hasConcept C185592680 @default.
• W1976948995 hasConcept C203014093 @default.
• W1976948995 hasConcept C2779726688 @default.
• W1976948995 hasConcept C49039625 @default.
• W1976948995 hasConcept C49802076 @default.
• W1976948995 hasConcept C519063684 @default.
• W1976948995 hasConcept C55493867 @default.
• W1976948995 hasConcept C86803240 @default.
• W1976948995 hasConcept C95444343 @default.
• W1976948995 hasConcept C98539663 @default.
• W1976948995 hasConceptScore W1976948995C12554922 @default.
• W1976948995 hasConceptScore W1976948995C141105273 @default.
• W1976948995 hasConceptScore W1976948995C147483822 @default.
• W1976948995 hasConceptScore W1976948995C159654299 @default.
• W1976948995 hasConceptScore W1976948995C170493617 @default.
• W1976948995 hasConceptScore W1976948995C178790620 @default.
• W1976948995 hasConceptScore W1976948995C181199279 @default.
• W1976948995 hasConceptScore W1976948995C185592680 @default.
• W1976948995 hasConceptScore W1976948995C203014093 @default.
• W1976948995 hasConceptScore W1976948995C2779726688 @default.
• W1976948995 hasConceptScore W1976948995C49039625 @default.
• W1976948995 hasConceptScore W1976948995C49802076 @default.
• W1976948995 hasConceptScore W1976948995C519063684 @default.
• W1976948995 hasConceptScore W1976948995C55493867 @default.
• W1976948995 hasConceptScore W1976948995C86803240 @default.
• W1976948995 hasConceptScore W1976948995C95444343 @default.
• W1976948995 hasConceptScore W1976948995C98539663 @default.
• W1976948995 hasIssue "2-3" @default.
• W1976948995 hasLocation W19769489951 @default.
• W1976948995 hasLocation W19769489952 @default.
• W1976948995 hasOpenAccess W1976948995 @default.
• W1976948995 hasPrimaryLocation W19769489951 @default.
• W1976948995 hasRelatedWork W1865570814 @default.
• W1976948995 hasRelatedWork W1996314176 @default.
• W1976948995 hasRelatedWork W2000366181 @default.
• W1976948995 hasRelatedWork W2017586984 @default.
• W1976948995 hasRelatedWork W2056727504 @default.
• W1976948995 hasRelatedWork W2142119474 @default.
• W1976948995 hasRelatedWork W2145832723 @default.
• W1976948995 hasRelatedWork W2264919710 @default.
• W1976948995 hasRelatedWork W2583825327 @default.

• next