Matches in SemOpenAlex for { <https://semopenalex.org/work/W1976954378> ?p ?o ?g. }
Showing items 1 to 87 of
87
with 100 items per page.
- W1976954378 endingPage "445" @default.
- W1976954378 startingPage "441" @default.
- W1976954378 abstract "Summary: Concanavalin A surface receptors were detected on brush border enterocytes from child intestinal biopsies by the concanavalin A-peroxidase method. On electron microscopy, these receptors appeared as electron-dense deposits, located on a band running along the innermost part of the brush border membrane glycocalyx. In the five control subjects tested, brush border length was 1.06 ± 0.18 μ, and band thickness, 19 ± 4 nm. Deposits were regular in shape and evenly spaced out along the entire membrane, reflecting homogeneous glycosylation of the normal brush border. In seven patients with villous atrophy induced by gluten, the brush border was damaged and its length was 1.04 ± 0.39 μ. The thickness of the electron-dense deposit band was 19 ± 6 nm; deposit shape was irregular and the band ran discontinuously along the membrane. The degree of this abnormality seemed to correspond to the degree of brush border damage. In six treated coeliac patients with normalized mucosa, the brush border was structurally normal but it was significantly longer (1.25 ± 0.32 μ) than in the controls (p < 0.01). The electron-dense band was significantly thinner (16 ± 7 nm) than in the controls (p < 0.01). The distribution of the electron-dense deposits was sporadic in some parts of the band and regular in others. These results suggest abnormal glycosylation of the brush border membrane in coeliac disease, and might be due to the presence of abnormal glycoconjugates. It remains to be established if these changes are induced by gluten toxicity or are the consequences of nonspecific intestinal disorders. Speculation: Glycoconjugates are the most important component of the brush border glycocalyx. During gluten-induced villous atrophy, the most mature enterocytes exhibit an abnormal glycocalyx. We therefore investigated coeliac and noncoeliac patients by the concanavalin A-peroxidase method in order to examine brush border enterocyte glycoconjugates by electron microscopy." @default.
- W1976954378 created "2016-06-24" @default.
- W1976954378 creator A5030119347 @default.
- W1976954378 creator A5056950573 @default.
- W1976954378 creator A5082052709 @default.
- W1976954378 date "1982-06-01" @default.
- W1976954378 modified "2023-09-27" @default.
- W1976954378 title "Ultrastructural Localization of Concanavalin A Surface Receptors on Brush-Border Enterocytes in Normal Children and during Coeliac Disease" @default.
- W1976954378 doi "https://doi.org/10.1203/00006450-198206000-00008" @default.
- W1976954378 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/7099760" @default.
- W1976954378 hasPublicationYear "1982" @default.
- W1976954378 type Work @default.
- W1976954378 sameAs 1976954378 @default.
- W1976954378 citedByCount "4" @default.
- W1976954378 crossrefType "journal-article" @default.
- W1976954378 hasAuthorship W1976954378A5030119347 @default.
- W1976954378 hasAuthorship W1976954378A5056950573 @default.
- W1976954378 hasAuthorship W1976954378A5082052709 @default.
- W1976954378 hasBestOaLocation W19769543781 @default.
- W1976954378 hasConcept C119062480 @default.
- W1976954378 hasConcept C12554922 @default.
- W1976954378 hasConcept C130316041 @default.
- W1976954378 hasConcept C142724271 @default.
- W1976954378 hasConcept C153911025 @default.
- W1976954378 hasConcept C158617107 @default.
- W1976954378 hasConcept C159985019 @default.
- W1976954378 hasConcept C16108499 @default.
- W1976954378 hasConcept C185592680 @default.
- W1976954378 hasConcept C192562407 @default.
- W1976954378 hasConcept C19869320 @default.
- W1976954378 hasConcept C202751555 @default.
- W1976954378 hasConcept C2779134260 @default.
- W1976954378 hasConcept C2780098789 @default.
- W1976954378 hasConcept C2780175098 @default.
- W1976954378 hasConcept C2780349322 @default.
- W1976954378 hasConcept C2780758401 @default.
- W1976954378 hasConcept C2993432164 @default.
- W1976954378 hasConcept C41625074 @default.
- W1976954378 hasConcept C5426402 @default.
- W1976954378 hasConcept C55493867 @default.
- W1976954378 hasConcept C71924100 @default.
- W1976954378 hasConcept C86803240 @default.
- W1976954378 hasConceptScore W1976954378C119062480 @default.
- W1976954378 hasConceptScore W1976954378C12554922 @default.
- W1976954378 hasConceptScore W1976954378C130316041 @default.
- W1976954378 hasConceptScore W1976954378C142724271 @default.
- W1976954378 hasConceptScore W1976954378C153911025 @default.
- W1976954378 hasConceptScore W1976954378C158617107 @default.
- W1976954378 hasConceptScore W1976954378C159985019 @default.
- W1976954378 hasConceptScore W1976954378C16108499 @default.
- W1976954378 hasConceptScore W1976954378C185592680 @default.
- W1976954378 hasConceptScore W1976954378C192562407 @default.
- W1976954378 hasConceptScore W1976954378C19869320 @default.
- W1976954378 hasConceptScore W1976954378C202751555 @default.
- W1976954378 hasConceptScore W1976954378C2779134260 @default.
- W1976954378 hasConceptScore W1976954378C2780098789 @default.
- W1976954378 hasConceptScore W1976954378C2780175098 @default.
- W1976954378 hasConceptScore W1976954378C2780349322 @default.
- W1976954378 hasConceptScore W1976954378C2780758401 @default.
- W1976954378 hasConceptScore W1976954378C2993432164 @default.
- W1976954378 hasConceptScore W1976954378C41625074 @default.
- W1976954378 hasConceptScore W1976954378C5426402 @default.
- W1976954378 hasConceptScore W1976954378C55493867 @default.
- W1976954378 hasConceptScore W1976954378C71924100 @default.
- W1976954378 hasConceptScore W1976954378C86803240 @default.
- W1976954378 hasIssue "6" @default.
- W1976954378 hasLocation W19769543781 @default.
- W1976954378 hasLocation W19769543782 @default.
- W1976954378 hasOpenAccess W1976954378 @default.
- W1976954378 hasPrimaryLocation W19769543781 @default.
- W1976954378 hasRelatedWork W118810016 @default.
- W1976954378 hasRelatedWork W1491601308 @default.
- W1976954378 hasRelatedWork W1917913087 @default.
- W1976954378 hasRelatedWork W1976954378 @default.
- W1976954378 hasRelatedWork W1984324813 @default.
- W1976954378 hasRelatedWork W1986073869 @default.
- W1976954378 hasRelatedWork W2087531955 @default.
- W1976954378 hasRelatedWork W2088067614 @default.
- W1976954378 hasRelatedWork W2098544916 @default.
- W1976954378 hasRelatedWork W4242737534 @default.
- W1976954378 hasVolume "16" @default.
- W1976954378 isParatext "false" @default.
- W1976954378 isRetracted "false" @default.
- W1976954378 magId "1976954378" @default.
- W1976954378 workType "article" @default.