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• W1976955013 abstract "Gadolinium chloride (GdCl 3 ), a Kupffer cells inhibitor, attenuates acute lung injury; however, the mechanisms behind this effect are not completely elucidated. We tested the hypothesis that GdCl 3 acts through the inhibition of lung parenchymal cellular apoptosis. Two groups of rats were injected intraperitoneally with saline or E. coli lipopolysaccharide. In two additional groups, rats were injected with GdCl 3 24 hrs prior to saline or LPS administration. At 12 hrs, lung injury, inflammation, and apoptosis were studied. Lung water content, myeloperoxidase activity, pulmonary apoptosis and mRNA levels of interleukin-1 β , -2, -5, -6, -10 and TNF- α rose significantly in LPS-injected animals. Pretreatment with GdCl 3 significantly reduced LPS-induced elevation of pulmonary water content, myeloperoxidase activity, cleaved caspase-3 intensity, and attenuated pulmonary TUNEL-positive cells. GdCl 3 pre-treatment upregulated IL-1 β , -2 and -10 pulmonary gene expression without significantly affecting the others. These results suggest that GdCl 3 attenuates acute lung injury through its effects on pulmonary parenchymal apoptosis." @default.
• W1976955013 created "2016-06-24" @default.
• W1976955013 creator A5038014128 @default.
• W1976955013 creator A5054459144 @default.
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• W1976955013 date "2012-11-01" @default.
• W1976955013 modified "2023-09-27" @default.
• W1976955013 title "Gadolinium Chloride Attenuates Sepsis-Induced Pulmonary Apoptosis and Acute Lung Injury" @default.
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• W1976955013 doi "https://doi.org/10.5402/2012/393481" @default.
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