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• W1976967535 abstract "We screened proteins for interaction with Alzheimer's β-amyloid precursor protein (APP) and cloned a new member of the X11 protein family, X11L2. The PID/PTB element of X11L2 protein interacted with the intracellular domain of APP by GST binding assay, andin vivointeraction was confirmed by coimmunoprecipitation from cell extracts overexpressing APP and HA-tagged X11L2. This gene encoded 575 amino acids and the deduced amino acid sequence was highly homologous to rat Mint3. Three protein–protein interaction domains, a PID/PTB and two PDZ elements, were conserved among the X11 protein family, and the N-terminal region of X11L2 protein had several putative SH3 binding motifs, PXXP. Unlike other members of the X11 protein family, X11L2 mRNA was expressed in various tissues." @default.
• W1976967535 created "2016-06-24" @default.
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• W1976967535 date "1999-02-01" @default.
• W1976967535 modified "2023-09-27" @default.
• W1976967535 title "X11L2, a New Member of the X11 Protein Family, Interacts with Alzheimer's β-Amyloid Precursor Protein" @default.
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• W1976967535 doi "https://doi.org/10.1006/bbrc.1999.0265" @default.
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