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- W1976967609 abstract "The maintenance of health depends on the coordinated and tightly regulated expression of genetic information. Certain forms of leukemia have become paradigms for the pathogenic role of aberrant repression of differentiation genes. In these acute leukemias, fusion proteins generated by chromosomal translocations no longer function as transcriptional activators, but instead repress target genes by recruiting histone deacetylases (HDACs). The potential benefit of HDAC inhibition has been established by the use of enzyme inhibitors in vitro and in a single reported case of experimental therapy. Because recently identified HDAC inhibitors appear to overcome many drawbacks of early inhibitory compounds in clinical use, the stage is set to test the therapeutic value of HDAC inhibition in leukemias and in other diseases, including solid tumors and aberrant hormonal signaling. This review summarizes the range of diseases expected to respond to HDAC inhibition." @default.
- W1976967609 created "2016-06-24" @default.
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- W1976967609 creator A5015940174 @default.
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- W1976967609 date "2001-09-01" @default.
- W1976967609 modified "2023-10-09" @default.
- W1976967609 title "Histone deacetylase as a therapeutic target" @default.
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- W1976967609 doi "https://doi.org/10.1016/s1043-2760(01)00438-6" @default.
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