Matches in SemOpenAlex for { <https://semopenalex.org/work/W1976971837> ?p ?o ?g. }
Showing items 1 to 71 of
71
with 100 items per page.
- W1976971837 abstract "Interkeukin-6 (IL-6) is a pro-inflammatory cytokine found in cells, glia and neurons throughout the brain. Higher levels of IL-6 in older adults have been associated with physical and cognitive impairment (Jenny, French, Arnold, Strotmeyer, Cushman, Chaves et al., 2012), as well as increased dementia risk (Singh & Newman, 2010). The association between IL-6 levels and age-related brain changes is less clear. In the present study, we used longitudinal MRI data on brain structure to investigate the relation between IL-6 concentrations and the process of cortical thinning with age. MRI scans from the Baltimore Longitudinal Study of Aging were analyzed for 121 non-demented older subjects (M = 73.3; SD = 7.8; Range = 56.1 - 94.1 yrs) who were repeatedly tested over an average period of 7.5 yrs. The Freesurfer longitudinal analysis processing stream was utilized for image processing of volumetric spoiled gradient recalled (SPGR) MR images, and IL-6 measures were based on serum ELISA assays (R&D System, Minneapolis, MN) with intra and inter- assay variations of 1.6% to 4.2% and 3.3% to 6.4% respectively. The minimum detectable dose (MDD) of IL-6 was less than 0.70 pg/ml. Statistical analysis was performed using a mixed effects model adapted for local analysis, with baseline age and sex as covariates. Results showed that higher mean IL-6 concentrations were associated with accelerated annual rates of cortical thinning in the temporal poles bilaterally. Additional pronounced regions included the middle frontal gyrus, pars opercularis and lateral occipital gyrus within the left hemisphere, and lateral postcentral gyrus and inferior temporal gyrus within the right hemisphere (all maps thresholded to corresponding p values 0.0005–0.01)." @default.
- W1976971837 created "2016-06-24" @default.
- W1976971837 creator A5000777749 @default.
- W1976971837 creator A5003112344 @default.
- W1976971837 creator A5022488909 @default.
- W1976971837 creator A5037684812 @default.
- W1976971837 creator A5039433114 @default.
- W1976971837 creator A5069442898 @default.
- W1976971837 creator A5077203436 @default.
- W1976971837 creator A5089482025 @default.
- W1976971837 date "2013-07-01" @default.
- W1976971837 modified "2023-10-16" @default.
- W1976971837 title "P1-407: Interleukin-6 (IL-6) is associated with longitudinal rates of cortical thinning" @default.
- W1976971837 doi "https://doi.org/10.1016/j.jalz.2013.05.635" @default.
- W1976971837 hasPublicationYear "2013" @default.
- W1976971837 type Work @default.
- W1976971837 sameAs 1976971837 @default.
- W1976971837 citedByCount "1" @default.
- W1976971837 countsByYear W19769718372016 @default.
- W1976971837 crossrefType "journal-article" @default.
- W1976971837 hasAuthorship W1976971837A5000777749 @default.
- W1976971837 hasAuthorship W1976971837A5003112344 @default.
- W1976971837 hasAuthorship W1976971837A5022488909 @default.
- W1976971837 hasAuthorship W1976971837A5037684812 @default.
- W1976971837 hasAuthorship W1976971837A5039433114 @default.
- W1976971837 hasAuthorship W1976971837A5069442898 @default.
- W1976971837 hasAuthorship W1976971837A5077203436 @default.
- W1976971837 hasAuthorship W1976971837A5089482025 @default.
- W1976971837 hasConcept C126322002 @default.
- W1976971837 hasConcept C126838900 @default.
- W1976971837 hasConcept C142724271 @default.
- W1976971837 hasConcept C143409427 @default.
- W1976971837 hasConcept C2777895361 @default.
- W1976971837 hasConcept C2779134260 @default.
- W1976971837 hasConcept C2779483572 @default.
- W1976971837 hasConcept C2779991468 @default.
- W1976971837 hasConcept C2984863031 @default.
- W1976971837 hasConcept C71924100 @default.
- W1976971837 hasConcept C74909509 @default.
- W1976971837 hasConcept C99476002 @default.
- W1976971837 hasConceptScore W1976971837C126322002 @default.
- W1976971837 hasConceptScore W1976971837C126838900 @default.
- W1976971837 hasConceptScore W1976971837C142724271 @default.
- W1976971837 hasConceptScore W1976971837C143409427 @default.
- W1976971837 hasConceptScore W1976971837C2777895361 @default.
- W1976971837 hasConceptScore W1976971837C2779134260 @default.
- W1976971837 hasConceptScore W1976971837C2779483572 @default.
- W1976971837 hasConceptScore W1976971837C2779991468 @default.
- W1976971837 hasConceptScore W1976971837C2984863031 @default.
- W1976971837 hasConceptScore W1976971837C71924100 @default.
- W1976971837 hasConceptScore W1976971837C74909509 @default.
- W1976971837 hasConceptScore W1976971837C99476002 @default.
- W1976971837 hasIssue "4S_Part_8" @default.
- W1976971837 hasLocation W19769718371 @default.
- W1976971837 hasOpenAccess W1976971837 @default.
- W1976971837 hasPrimaryLocation W19769718371 @default.
- W1976971837 hasRelatedWork W124560264 @default.
- W1976971837 hasRelatedWork W1539624876 @default.
- W1976971837 hasRelatedWork W1885211110 @default.
- W1976971837 hasRelatedWork W2005941035 @default.
- W1976971837 hasRelatedWork W2518708114 @default.
- W1976971837 hasRelatedWork W2726371196 @default.
- W1976971837 hasRelatedWork W2766474056 @default.
- W1976971837 hasRelatedWork W2885330862 @default.
- W1976971837 hasRelatedWork W2897615647 @default.
- W1976971837 hasRelatedWork W3214461917 @default.
- W1976971837 hasVolume "9" @default.
- W1976971837 isParatext "false" @default.
- W1976971837 isRetracted "false" @default.
- W1976971837 magId "1976971837" @default.
- W1976971837 workType "article" @default.