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- W1976974906 abstract "The effect of ondansetron, a 5-HT3 antagonist, in preventing postoperative nausea and vomiting was investigated in a randomized, double-blind, placebo-controlled study of 84 patients undergoing gynecologic operation and receiving the same general anesthetic. The patients received premedication with either 16 mg oral ondansetron, or a matching placebo. The same medication was given postoperatively 8 h after the first dose. During the first hour after recovery from anesthesia, the frequencies of nausea and vomiting were 52% and 40%, respectively, in patients given placebos. In the ondansetron group nausea and vomiting developed in 17% and 12%, respectively, values significantly different from those with placebos (P < 0.005). Similar differences were observed throughout the entire 24-h period after recovery, the incidence of nausea and vomiting being 67% and 60%, respectively, in the placebo group and 29% and 26% in the ondansetron treatment group. Ondansetron appears to be a promising antiemetic for the prevention of postoperative nausea and vomiting." @default.
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- W1976974906 date "1991-06-01" @default.
- W1976974906 modified "2023-10-18" @default.
- W1976974906 title "Prevention of Postoperative Nausea and Vomiting Using Ondansetron, a New, Selective, 5-HT3 Receptor Antagonist" @default.
- W1976974906 doi "https://doi.org/10.1213/00000539-199106000-00005" @default.
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