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• W1976981044 abstract "Microfluidic chip-based hydrophilic interaction chromatography (HILIC) is a useful separation system for liquid chromatography–mass spectrometry (LC-MS) in compositional profiling of heparan sulfate (HS) oligosaccharides; however, ions observed using HILIC LC-MS are low in charge. Tandem MS of HS oligosaccharide ions with low charge results in undesirable losses of SO3 from precursor ions during collision induced dissociation. One solution is to add metal cations to stabilize sulfate groups. Another is to add a nonvolatile, polar compound such as sulfolane, a molecule known to supercharge proteins, to produce a similar effect for oligosaccharides. We demonstrate use of a novel pulsed makeup flow (MUF) HPLC-chip. The chip enables controlled application of additives during specified chromatographic time windows and thus minimizes the extent to which nonvolatile additives build up in the ion source. The pulsed MUF system was applied to LC-MS/MS of HS oligosaccharides. Metal cations and sulfolane were tested as additives. The most promising results were obtained for sulfolane, for which supercharging of the oligosaccharide ions increased their signal strengths relative to controls. Tandem MS of these supercharged precursor ions showed decreased abundances of product ions from sulfate losses yet more abundant product ions from backbone cleavages." @default.
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• W1976981044 date "2011-10-07" @default.
• W1976981044 modified "2023-10-18" @default.
• W1976981044 title "Improved Liquid Chromatography-MS/MS of Heparan Sulfate Oligosaccharides via Chip-Based Pulsed Makeup Flow" @default.
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• W1976981044 doi "https://doi.org/10.1021/ac201964n" @default.
• W1976981044 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3205275" @default.
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