Matches in SemOpenAlex for { <https://semopenalex.org/work/W1976981405> ?p ?o ?g. }
- W1976981405 endingPage "2072" @default.
- W1976981405 startingPage "2063" @default.
- W1976981405 abstract "Abstract Transmissible prion diseases are fatal neurodegenerative diseases associated with the conversion of the normal host prion protein (PrP c ) into an abnormal isoform (PrP Sc ) that accumulates in brain. This pathology affects neurons of the central nervous system whereas no clear toxic effect has been reported for peripheral neurons. We examined the subcellular distribution of PrP c and PrP Sc in the scrapie‐infected mouse neuronal cell lines GT1‐7 and N2a, derived, respectively, from the central and peripheral nervous system. We observed that in both cell types, PrP c is present in the endocytic compartment, mainly in LAMP‐1‐positive late endosomes, but excluded from LYAAT‐1‐lysosomes. In contrast, PrP Sc was distributed differently in the two cell lines. In infected N2a, PrP Sc and PrP c had comparable distribution patterns. In infected GT1‐7, PrP Sc is present in an additional vesicular compartment which is flotillin‐1‐positive. The level of expression of flotillin‐1 is higher in GT1‐7 than in N2a cells, but no difference is observed between infected and noninfected cells. In Alzheimer's disease patients, it has been reported that flotillin‐1 is abundant in brain areas containing the β‐amyloid protein, which accumulates in endosomal vesicles in primary neurons. We propose that the flotillin compartment could store aggregated proteins and play a role in these neurodegenerative pathologies." @default.
- W1976981405 created "2016-06-24" @default.
- W1976981405 creator A5024675355 @default.
- W1976981405 creator A5027154404 @default.
- W1976981405 creator A5078736735 @default.
- W1976981405 date "2005-04-01" @default.
- W1976981405 modified "2023-10-10" @default.
- W1976981405 title "The scrapie prion protein is present in flotillin-1-positive vesicles in central- but not peripheral-derived neuronal cell lines" @default.
- W1976981405 cites W109745037 @default.
- W1976981405 cites W1559460715 @default.
- W1976981405 cites W1567267284 @default.
- W1976981405 cites W1590689549 @default.
- W1976981405 cites W1933863182 @default.
- W1976981405 cites W1965378784 @default.
- W1976981405 cites W1969302990 @default.
- W1976981405 cites W1985826693 @default.
- W1976981405 cites W1987066803 @default.
- W1976981405 cites W1991854031 @default.
- W1976981405 cites W1995673366 @default.
- W1976981405 cites W2000356901 @default.
- W1976981405 cites W2003022420 @default.
- W1976981405 cites W2004369117 @default.
- W1976981405 cites W2007107646 @default.
- W1976981405 cites W2009751007 @default.
- W1976981405 cites W2010238780 @default.
- W1976981405 cites W2021518229 @default.
- W1976981405 cites W2022392367 @default.
- W1976981405 cites W2024954984 @default.
- W1976981405 cites W2032604948 @default.
- W1976981405 cites W2034359525 @default.
- W1976981405 cites W2038887966 @default.
- W1976981405 cites W2043943109 @default.
- W1976981405 cites W2052976709 @default.
- W1976981405 cites W2053285895 @default.
- W1976981405 cites W2062379645 @default.
- W1976981405 cites W2063880942 @default.
- W1976981405 cites W2067544586 @default.
- W1976981405 cites W2077404304 @default.
- W1976981405 cites W2081812996 @default.
- W1976981405 cites W2081852339 @default.
- W1976981405 cites W2089507595 @default.
- W1976981405 cites W2090175640 @default.
- W1976981405 cites W2091191443 @default.
- W1976981405 cites W2091849161 @default.
- W1976981405 cites W2093394063 @default.
- W1976981405 cites W2094584435 @default.
- W1976981405 cites W2102696072 @default.
- W1976981405 cites W2106235316 @default.
- W1976981405 cites W2106769886 @default.
- W1976981405 cites W2114496280 @default.
- W1976981405 cites W2118510702 @default.
- W1976981405 cites W2119080693 @default.
- W1976981405 cites W2119421760 @default.
- W1976981405 cites W2121506107 @default.
- W1976981405 cites W2121936687 @default.
- W1976981405 cites W2124342403 @default.
- W1976981405 cites W2125233904 @default.
- W1976981405 cites W2128779293 @default.
- W1976981405 cites W2134139236 @default.
- W1976981405 cites W2139174538 @default.
- W1976981405 cites W2142672347 @default.
- W1976981405 cites W2145836316 @default.
- W1976981405 cites W2147251439 @default.
- W1976981405 cites W2147585986 @default.
- W1976981405 cites W2151131543 @default.
- W1976981405 cites W2157234645 @default.
- W1976981405 cites W2161396884 @default.
- W1976981405 cites W2166486694 @default.
- W1976981405 cites W97309465 @default.
- W1976981405 doi "https://doi.org/10.1111/j.1460-9568.2005.04049.x" @default.
- W1976981405 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15869502" @default.
- W1976981405 hasPublicationYear "2005" @default.
- W1976981405 type Work @default.
- W1976981405 sameAs 1976981405 @default.
- W1976981405 citedByCount "63" @default.
- W1976981405 countsByYear W19769814052012 @default.
- W1976981405 countsByYear W19769814052013 @default.
- W1976981405 countsByYear W19769814052014 @default.
- W1976981405 countsByYear W19769814052015 @default.
- W1976981405 countsByYear W19769814052016 @default.
- W1976981405 countsByYear W19769814052017 @default.
- W1976981405 countsByYear W19769814052018 @default.
- W1976981405 countsByYear W19769814052019 @default.
- W1976981405 countsByYear W19769814052020 @default.
- W1976981405 countsByYear W19769814052022 @default.
- W1976981405 countsByYear W19769814052023 @default.
- W1976981405 crossrefType "journal-article" @default.
- W1976981405 hasAuthorship W1976981405A5024675355 @default.
- W1976981405 hasAuthorship W1976981405A5027154404 @default.
- W1976981405 hasAuthorship W1976981405A5078736735 @default.
- W1976981405 hasConcept C102747710 @default.
- W1976981405 hasConcept C104317684 @default.
- W1976981405 hasConcept C111368507 @default.
- W1976981405 hasConcept C127313418 @default.
- W1976981405 hasConcept C142724271 @default.
- W1976981405 hasConcept C1491633281 @default.
- W1976981405 hasConcept C153911025 @default.
- W1976981405 hasConcept C169760540 @default.