Matches in SemOpenAlex for { <https://semopenalex.org/work/W1976983023> ?p ?o ?g. }
Showing items 1 to 67 of
67
with 100 items per page.
- W1976983023 abstract "The tertiary nitrogen derivative of carbachol, N-demethylated carbachol, was synthesized to produce a drug that could be used as an alternative to pilocarpine in the treatment of open-angle glaucoma. Unlike pilocarpine, N-demethylated carbachol appeared to be stable in alkaline solutions. Since pilocarpine has to be dissolved in an acidic medium (pH 5.5) to prevent its destruction, less than 10% of its molecules are in an unionized form. On the other hand, N-demethylated carbachol is very stable at pH values higher than 7.4 and thus has more molecules (greater than 10%) in an unionized, penetrable form than does pilocarpine in high pH media. N-Demethylated carbachol acted as a full agonist on isolated dog iris and ciliary muscle preparations, whereas pilocarpine produced only 49 and 38% of the maximum tissue responses, respectively. These findings suggest that N-demethylated carbachol may be able to affect the outflow facility to a greater extent than is achievable with pilocarpine at high doses." @default.
- W1976983023 created "2016-06-24" @default.
- W1976983023 creator A5005821761 @default.
- W1976983023 creator A5073031479 @default.
- W1976983023 date "1980-03-01" @default.
- W1976983023 modified "2023-09-24" @default.
- W1976983023 title "Effects of N-demethylated Carbachol on Iris and Ciliary Muscles" @default.
- W1976983023 cites W1964100147 @default.
- W1976983023 cites W1965882255 @default.
- W1976983023 cites W1970127416 @default.
- W1976983023 cites W1976811894 @default.
- W1976983023 cites W2002453043 @default.
- W1976983023 cites W2016216057 @default.
- W1976983023 cites W2031788909 @default.
- W1976983023 cites W2161369548 @default.
- W1976983023 cites W2618743006 @default.
- W1976983023 doi "https://doi.org/10.1002/jps.2600690320" @default.
- W1976983023 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/7381712" @default.
- W1976983023 hasPublicationYear "1980" @default.
- W1976983023 type Work @default.
- W1976983023 sameAs 1976983023 @default.
- W1976983023 citedByCount "6" @default.
- W1976983023 crossrefType "journal-article" @default.
- W1976983023 hasAuthorship W1976983023A5005821761 @default.
- W1976983023 hasAuthorship W1976983023A5073031479 @default.
- W1976983023 hasConcept C134018914 @default.
- W1976983023 hasConcept C157660682 @default.
- W1976983023 hasConcept C169760540 @default.
- W1976983023 hasConcept C170493617 @default.
- W1976983023 hasConcept C185592680 @default.
- W1976983023 hasConcept C2777204577 @default.
- W1976983023 hasConcept C2778186239 @default.
- W1976983023 hasConcept C2778988552 @default.
- W1976983023 hasConcept C2780718027 @default.
- W1976983023 hasConcept C55493867 @default.
- W1976983023 hasConcept C86803240 @default.
- W1976983023 hasConcept C98274493 @default.
- W1976983023 hasConceptScore W1976983023C134018914 @default.
- W1976983023 hasConceptScore W1976983023C157660682 @default.
- W1976983023 hasConceptScore W1976983023C169760540 @default.
- W1976983023 hasConceptScore W1976983023C170493617 @default.
- W1976983023 hasConceptScore W1976983023C185592680 @default.
- W1976983023 hasConceptScore W1976983023C2777204577 @default.
- W1976983023 hasConceptScore W1976983023C2778186239 @default.
- W1976983023 hasConceptScore W1976983023C2778988552 @default.
- W1976983023 hasConceptScore W1976983023C2780718027 @default.
- W1976983023 hasConceptScore W1976983023C55493867 @default.
- W1976983023 hasConceptScore W1976983023C86803240 @default.
- W1976983023 hasConceptScore W1976983023C98274493 @default.
- W1976983023 hasLocation W19769830231 @default.
- W1976983023 hasLocation W19769830232 @default.
- W1976983023 hasOpenAccess W1976983023 @default.
- W1976983023 hasPrimaryLocation W19769830231 @default.
- W1976983023 hasRelatedWork W1457058838 @default.
- W1976983023 hasRelatedWork W1901275661 @default.
- W1976983023 hasRelatedWork W1976983023 @default.
- W1976983023 hasRelatedWork W1978009 @default.
- W1976983023 hasRelatedWork W1992623642 @default.
- W1976983023 hasRelatedWork W199960297 @default.
- W1976983023 hasRelatedWork W2039884104 @default.
- W1976983023 hasRelatedWork W2050559793 @default.
- W1976983023 hasRelatedWork W2414099715 @default.
- W1976983023 hasRelatedWork W2469986830 @default.
- W1976983023 isParatext "false" @default.
- W1976983023 isRetracted "false" @default.
- W1976983023 magId "1976983023" @default.
- W1976983023 workType "article" @default.