FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1976983152> ?p ?o ?g. }

• W1976983152 endingPage "332" @default.
• W1976983152 startingPage "327" @default.
• W1976983152 abstract "MicroRNAs (miRNAs) are small noncoding RNAs that function as tumor suppressors or oncogenes. MicroRNA-107 (miR-107), a transcriptional target of p53, is deregulated in many cancer cell lines. Here, we showed that miR-107 is down-regulated in glioma tissues and cell lines, in particular, p53-mutated U251 and A172. Transfection of wild-type p53 into these cells stimulated miR-107 expression. To investigate the role of miR-107 in tumorigenesis, we constructed a lentiviral vector overexpressing miR-107. Notably, miR-107 inhibited proliferation and arrested the cell cycle at the G0-G1 phase in glioma cells. Transduction of Lenti-GFP-miR-107 into glioma cells inhibited CDK6 and Notch-2 protein expression. Our findings collectively demonstrate that p53-induced miR-107 suppresses brain tumor cell growth and down-regulates CDK6 and Notch-2 expression, supporting its tumor suppressor role and utility as a target for glioma therapy." @default.
• W1976983152 created "2016-06-24" @default.
• W1976983152 creator A5005449938 @default.
• W1976983152 creator A5017100729 @default.
• W1976983152 creator A5028088794 @default.
• W1976983152 creator A5029189331 @default.
• W1976983152 creator A5048893081 @default.
• W1976983152 creator A5049267896 @default.
• W1976983152 creator A5050772776 @default.
• W1976983152 creator A5071211303 @default.
• W1976983152 creator A5071458554 @default.
• W1976983152 date "2013-02-01" @default.
• W1976983152 modified "2023-10-12" @default.
• W1976983152 title "P53-induced microRNA-107 inhibits proliferation of glioma cells and down-regulates the expression of CDK6 and Notch-2" @default.
• W1976983152 cites W144423133 @default.
• W1976983152 cites W1971831496 @default.
• W1976983152 cites W1972380031 @default.
• W1976983152 cites W1976549493 @default.
• W1976983152 cites W1977932018 @default.
• W1976983152 cites W1999475535 @default.
• W1976983152 cites W2010402627 @default.
• W1976983152 cites W2013171299 @default.
• W1976983152 cites W2013721931 @default.
• W1976983152 cites W2014205072 @default.
• W1976983152 cites W2024837427 @default.
• W1976983152 cites W2030120875 @default.
• W1976983152 cites W2036013203 @default.
• W1976983152 cites W2036044314 @default.
• W1976983152 cites W2057144418 @default.
• W1976983152 cites W2070032322 @default.
• W1976983152 cites W2083381199 @default.
• W1976983152 cites W2093364931 @default.
• W1976983152 cites W2094900768 @default.
• W1976983152 cites W2096287682 @default.
• W1976983152 cites W2103592738 @default.
• W1976983152 cites W2103724228 @default.
• W1976983152 cites W2104902048 @default.
• W1976983152 cites W2107277218 @default.
• W1976983152 cites W2119117210 @default.
• W1976983152 cites W2127207254 @default.
• W1976983152 cites W2133409869 @default.
• W1976983152 cites W2134895500 @default.
• W1976983152 cites W2139966272 @default.
• W1976983152 cites W2151335185 @default.
• W1976983152 cites W2159888101 @default.
• W1976983152 cites W2164194749 @default.
• W1976983152 doi "https://doi.org/10.1016/j.neulet.2012.11.047" @default.
• W1976983152 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23220650" @default.
• W1976983152 hasPublicationYear "2013" @default.
• W1976983152 type Work @default.
• W1976983152 sameAs 1976983152 @default.
• W1976983152 citedByCount "56" @default.
• W1976983152 countsByYear W19769831522013 @default.
• W1976983152 countsByYear W19769831522014 @default.
• W1976983152 countsByYear W19769831522015 @default.
• W1976983152 countsByYear W19769831522016 @default.
• W1976983152 countsByYear W19769831522017 @default.
• W1976983152 countsByYear W19769831522018 @default.
• W1976983152 countsByYear W19769831522019 @default.
• W1976983152 countsByYear W19769831522020 @default.
• W1976983152 countsByYear W19769831522021 @default.
• W1976983152 countsByYear W19769831522022 @default.
• W1976983152 countsByYear W19769831522023 @default.
• W1976983152 crossrefType "journal-article" @default.
• W1976983152 hasAuthorship W1976983152A5005449938 @default.
• W1976983152 hasAuthorship W1976983152A5017100729 @default.
• W1976983152 hasAuthorship W1976983152A5028088794 @default.
• W1976983152 hasAuthorship W1976983152A5029189331 @default.
• W1976983152 hasAuthorship W1976983152A5048893081 @default.
• W1976983152 hasAuthorship W1976983152A5049267896 @default.
• W1976983152 hasAuthorship W1976983152A5050772776 @default.
• W1976983152 hasAuthorship W1976983152A5071211303 @default.
• W1976983152 hasAuthorship W1976983152A5071458554 @default.
• W1976983152 hasConcept C104317684 @default.
• W1976983152 hasConcept C121608353 @default.
• W1976983152 hasConcept C145059251 @default.
• W1976983152 hasConcept C1491633281 @default.
• W1976983152 hasConcept C161879069 @default.
• W1976983152 hasConcept C199649820 @default.
• W1976983152 hasConcept C2778227246 @default.
• W1976983152 hasConcept C29537977 @default.
• W1976983152 hasConcept C502942594 @default.
• W1976983152 hasConcept C54009773 @default.
• W1976983152 hasConcept C54355233 @default.
• W1976983152 hasConcept C555283112 @default.
• W1976983152 hasConcept C62112901 @default.
• W1976983152 hasConcept C62478195 @default.
• W1976983152 hasConcept C81885089 @default.
• W1976983152 hasConcept C82495950 @default.
• W1976983152 hasConcept C86803240 @default.
• W1976983152 hasConcept C95444343 @default.
• W1976983152 hasConceptScore W1976983152C104317684 @default.
• W1976983152 hasConceptScore W1976983152C121608353 @default.
• W1976983152 hasConceptScore W1976983152C145059251 @default.
• W1976983152 hasConceptScore W1976983152C1491633281 @default.
• W1976983152 hasConceptScore W1976983152C161879069 @default.
• W1976983152 hasConceptScore W1976983152C199649820 @default.
• W1976983152 hasConceptScore W1976983152C2778227246 @default.

• next