FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1976988157> ?p ?o ?g. }

• W1976988157 endingPage "153" @default.
• W1976988157 startingPage "133" @default.
• W1976988157 abstract "In parenteral nutrition, the infusion of a fat EMU supplies both concentrated energy and covers the essential fatty acid requirements, the basic objective being to mimic as well as possible the input of chylomicrons into the blood. This objective is well met by the TAGRP of the EMU, which behave as true chylomicrons. However, commercial EMU also contain an excess of emulsifier in the form of PLRP. The number of these PLRP depends directly on the PL/TAG ratio of the EMU. They differ from the TAGRP by their composition (PL vs TAG and PL), their structure (PL in bilayer versus monolayer), and their granulometry (mean diameter 70-100 nm for PL vs 200-500 nm). The metabolic fate of the PLRP is similar in several ways to that of the TAGRP: exchanges of PL with the PL of the different cellular membranes and of the lipoproteins; captation of free CH from these same structures; and enrichment in apolipoproteins. However, because the TAGRP are the preferred substrates of the lipolytic enzymes, their clearance is much more rapid (half-life < 1 h) than that of the PLRP. As the infusion is continued, the PLRP end up accumulating and being transformed into LP-X (free CH/PL = 1; half-life of several days). As soon as the EMU is infused, the PLRP enter into competition with the TAGRP, in the lipolysis process as well as for sites of binding and for catabolism. The sites for catabolism of the two types of PAR are not the same: adipose tissues and muscles utilize the fatty acids and monoacylglycerols released by the lipolysis of the TAGRP; hepatocytes take up their remnants; the RES and the hepatocytes participate in the catabolism of the PLRP and the LP-X. Thus, prolonged infusion of EMU rich in PLRP leads to a hypercholesterolemia, or at least a dyslipoproteinemia, due to elevated LP-X, associated with a depletion of cells in CH, stimulating thus tissue cholesterogenesis. However, parenteral nutrition has evolved towards the utilization of EMU with a low PL/TAG ratio (availability of 30% formula) and less rapid delivery. For these reasons, the hypercholesterolemias that used to be observed with the 10% EMU have become much less spectacular or have even disappeared. It is interesting to note that patients on prolonged TPN, in particular those with a short small intestine, have weak cholesterolemia, reflecting a lowering of HDL and LDL not masked by elevated LP-X. At present, it seems difficult to produce sufficiently stable parenteral EMU devoid of PLRP. Notwithstanding, all the observations made since the introduction of the EMU in TPN are in favour of the use of PLRP-poor EMU. It is clear that the 10% formulas, and generally those with a PL/TAG ratio of 12/100, are ill-advised, especially in patients with a retarded clearance of circulating lipids." @default.
• W1976988157 created "2016-06-24" @default.
• W1976988157 creator A5018355285 @default.
• W1976988157 creator A5057623037 @default.
• W1976988157 creator A5069359628 @default.
• W1976988157 date "1996-06-01" @default.
• W1976988157 modified "2023-09-29" @default.
• W1976988157 title "Phospholipid-rich particles in commercial parenteral fat emulsions. An overview" @default.
• W1976988157 cites W107407589 @default.
• W1976988157 cites W125758503 @default.
• W1976988157 cites W129219569 @default.
• W1976988157 cites W1417854361 @default.
• W1976988157 cites W1526016286 @default.
• W1976988157 cites W1531185348 @default.
• W1976988157 cites W1533285881 @default.
• W1976988157 cites W1536010954 @default.
• W1976988157 cites W1555567251 @default.
• W1976988157 cites W1588834902 @default.
• W1976988157 cites W1604074323 @default.
• W1976988157 cites W1648846307 @default.
• W1976988157 cites W1757677204 @default.
• W1976988157 cites W1763891037 @default.
• W1976988157 cites W1854168571 @default.
• W1976988157 cites W1854740206 @default.
• W1976988157 cites W1895722014 @default.
• W1976988157 cites W1921768926 @default.
• W1976988157 cites W1964150420 @default.
• W1976988157 cites W1964556723 @default.
• W1976988157 cites W1966256458 @default.
• W1976988157 cites W1967240083 @default.
• W1976988157 cites W1971590461 @default.
• W1976988157 cites W1971694090 @default.
• W1976988157 cites W1974698192 @default.
• W1976988157 cites W1975936284 @default.
• W1976988157 cites W1977210028 @default.
• W1976988157 cites W1978232475 @default.
• W1976988157 cites W1978447896 @default.
• W1976988157 cites W1978565984 @default.
• W1976988157 cites W1980484108 @default.
• W1976988157 cites W1981309636 @default.
• W1976988157 cites W1981942016 @default.
• W1976988157 cites W1985224004 @default.
• W1976988157 cites W1985778027 @default.
• W1976988157 cites W1986923987 @default.
• W1976988157 cites W1988498959 @default.
• W1976988157 cites W1988644545 @default.
• W1976988157 cites W1990167798 @default.
• W1976988157 cites W1990960038 @default.
• W1976988157 cites W1992304633 @default.
• W1976988157 cites W1993554328 @default.
• W1976988157 cites W1993924994 @default.
• W1976988157 cites W1994312676 @default.
• W1976988157 cites W1995632537 @default.
• W1976988157 cites W1999186186 @default.
• W1976988157 cites W2001684954 @default.
• W1976988157 cites W2002304174 @default.
• W1976988157 cites W2003507074 @default.
• W1976988157 cites W2008415028 @default.
• W1976988157 cites W2009876439 @default.
• W1976988157 cites W2016035593 @default.
• W1976988157 cites W2016298170 @default.
• W1976988157 cites W2018181366 @default.
• W1976988157 cites W2018227544 @default.
• W1976988157 cites W2020988155 @default.
• W1976988157 cites W2021177677 @default.
• W1976988157 cites W2023694676 @default.
• W1976988157 cites W2024086471 @default.
• W1976988157 cites W2024493540 @default.
• W1976988157 cites W2029648117 @default.
• W1976988157 cites W2029909250 @default.
• W1976988157 cites W2030028929 @default.
• W1976988157 cites W2030465062 @default.
• W1976988157 cites W20309224 @default.
• W1976988157 cites W2033145156 @default.
• W1976988157 cites W2035137798 @default.
• W1976988157 cites W2040149610 @default.
• W1976988157 cites W2041937505 @default.
• W1976988157 cites W2042567243 @default.
• W1976988157 cites W2043416788 @default.
• W1976988157 cites W2043811914 @default.
• W1976988157 cites W2044705103 @default.
• W1976988157 cites W2044790281 @default.
• W1976988157 cites W2047165740 @default.
• W1976988157 cites W2048961510 @default.
• W1976988157 cites W2049156260 @default.
• W1976988157 cites W2049298980 @default.
• W1976988157 cites W2056549748 @default.
• W1976988157 cites W2057444535 @default.
• W1976988157 cites W2057667069 @default.
• W1976988157 cites W2058041160 @default.
• W1976988157 cites W2058898326 @default.
• W1976988157 cites W2061226640 @default.
• W1976988157 cites W2063515636 @default.
• W1976988157 cites W2065777224 @default.
• W1976988157 cites W2066254317 @default.
• W1976988157 cites W2068045946 @default.
• W1976988157 cites W2068053744 @default.
• W1976988157 cites W2068626034 @default.

• next