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• W1976993923 endingPage "1913" @default.
• W1976993923 startingPage "1902" @default.
• W1976993923 abstract "Nine bromotyrosine-derived compounds were isolated from the Caribbean marine sponge Verongula rigida. Two of them, aeroplysinin-1 (1) and dihydroxyaerothionin (2), are known compounds for this species, and the other seven are unknown compounds for this species, namely: 3,5-dibromo-N,N,N-trimethyltyraminium (3), 3,5-dibromo-N,N,N, O-tetramethyltyraminium (4), purealidin R (5), 19-deoxyfistularin 3 (6), purealidin B (7), 11-hydroxyaerothionin (8) and fistularin-3 (9). Structural determination of the isolated compounds was performed using one- and two-dimensional NMR, MS and other spectroscopy data. All isolated compounds were screened for their in vitro activity against three parasitic protozoa: Leishmania panamensis, Plasmodium falciparum and Trypanosoma cruzi. Compounds 7 and 8 showed selective antiparasitic activity at 10 and 5 µM against Leishmania and Plasmodium parasites, respectively. Cytotoxicity of these compounds on a human promonocytic cell line was also assessed." @default.
• W1976993923 created "2016-06-24" @default.
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• W1976993923 date "2011-10-14" @default.
• W1976993923 modified "2023-09-25" @default.
• W1976993923 title "Antiparasitic Bromotyrosine Derivatives from the Marine Sponge Verongula rigida" @default.
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• W1976993923 doi "https://doi.org/10.3390/md9101902" @default.
• W1976993923 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3210611" @default.
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