FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1976995262> ?p ?o ?g. }

• W1976995262 abstract "ATP in the 100 muM-1 mM concentration range provoked a calcium-independent increase of the oxidation of dichlorodihydrofluorescein (DCFH) to dichlorofluorescein (DCF) by mouse submandibular cells. 3'-O-(4-benzoyl)benzoyl adenosine 5'-triphosphate (BzATP), a P2X(7) agonist, but not a muscarinic or an adrenergic agonist, reproduced the effect of ATP. The inhibition of phospholipase C by U73122 or the potentiation of P2X(4) receptor activation with ivermectin did not modify the response to ATP. ATP did not increase the oxidation of DCFH in cells isolated from submandibular glands of P2X(7) knockout mice or in cells pretreated with a P2X(7) antagonist. The inhibition of protein kinase C or of mitogen-activated protein kinase (MAP kinase) or of reduced nicotinamide adenine dinucleotide phosphate (NADPH) oxidase blocked the oxidation of DCFH without affecting the increase of the intracellular concentration of calcium or the uptake of ethidium bromide in response to extracellular ATP. From these results it is concluded that the activation of the P2X(7) receptors from submandibular glands triggers an intracellular signalling cascade involving protein kinase C and MAP kinase leading to the stimulation of NADPH oxidase and the subsequent generation of reactive oxygen species." @default.
• W1976995262 created "2016-06-24" @default.
• W1976995262 creator A5010212856 @default.
• W1976995262 creator A5025256752 @default.
• W1976995262 creator A5026504454 @default.
• W1976995262 creator A5041608898 @default.
• W1976995262 creator A5066125181 @default.
• W1976995262 creator A5069060358 @default.
• W1976995262 creator A5070810300 @default.
• W1976995262 date "2008-06-26" @default.
• W1976995262 modified "2023-10-18" @default.
• W1976995262 title "Pharmacological evidence for the stimulation of NADPH oxidase by P2X7 receptors in mouse submandibular glands" @default.
• W1976995262 cites W1529396499 @default.
• W1976995262 cites W1647222892 @default.
• W1976995262 cites W1801129364 @default.
• W1976995262 cites W1963859587 @default.
• W1976995262 cites W1965164425 @default.
• W1976995262 cites W1965343786 @default.
• W1976995262 cites W2006646148 @default.
• W1976995262 cites W2006787990 @default.
• W1976995262 cites W2013561452 @default.
• W1976995262 cites W2022377321 @default.
• W1976995262 cites W2035705887 @default.
• W1976995262 cites W2035936653 @default.
• W1976995262 cites W2049509414 @default.
• W1976995262 cites W2054571187 @default.
• W1976995262 cites W2057810394 @default.
• W1976995262 cites W2084383502 @default.
• W1976995262 cites W2086096042 @default.
• W1976995262 cites W2091509360 @default.
• W1976995262 cites W2095799155 @default.
• W1976995262 cites W2101692904 @default.
• W1976995262 cites W2102538853 @default.
• W1976995262 cites W2107684604 @default.
• W1976995262 cites W2110060263 @default.
• W1976995262 cites W2114467922 @default.
• W1976995262 cites W2119780153 @default.
• W1976995262 cites W2131720570 @default.
• W1976995262 cites W2141260882 @default.
• W1976995262 cites W2153177211 @default.
• W1976995262 cites W2156346381 @default.
• W1976995262 cites W2161997291 @default.
• W1976995262 cites W2162473874 @default.
• W1976995262 cites W2170068073 @default.
• W1976995262 cites W4234810216 @default.
• W1976995262 cites W2113059786 @default.
• W1976995262 doi "https://doi.org/10.1007/s11302-008-9118-y" @default.
• W1976995262 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2583204" @default.
• W1976995262 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18581262" @default.
• W1976995262 hasPublicationYear "2008" @default.
• W1976995262 type Work @default.
• W1976995262 sameAs 1976995262 @default.
• W1976995262 citedByCount "22" @default.
• W1976995262 countsByYear W19769952622012 @default.
• W1976995262 countsByYear W19769952622013 @default.
• W1976995262 countsByYear W19769952622014 @default.
• W1976995262 countsByYear W19769952622017 @default.
• W1976995262 countsByYear W19769952622021 @default.
• W1976995262 crossrefType "journal-article" @default.
• W1976995262 hasAuthorship W1976995262A5010212856 @default.
• W1976995262 hasAuthorship W1976995262A5025256752 @default.
• W1976995262 hasAuthorship W1976995262A5026504454 @default.
• W1976995262 hasAuthorship W1976995262A5041608898 @default.
• W1976995262 hasAuthorship W1976995262A5066125181 @default.
• W1976995262 hasAuthorship W1976995262A5069060358 @default.
• W1976995262 hasAuthorship W1976995262A5070810300 @default.
• W1976995262 hasBestOaLocation W19769952621 @default.
• W1976995262 hasConcept C134018914 @default.
• W1976995262 hasConcept C170493617 @default.
• W1976995262 hasConcept C181199279 @default.
• W1976995262 hasConcept C184235292 @default.
• W1976995262 hasConcept C185592680 @default.
• W1976995262 hasConcept C24998067 @default.
• W1976995262 hasConcept C2777989768 @default.
• W1976995262 hasConcept C2778597717 @default.
• W1976995262 hasConcept C2778938600 @default.
• W1976995262 hasConcept C2779719074 @default.
• W1976995262 hasConcept C38485361 @default.
• W1976995262 hasConcept C48349386 @default.
• W1976995262 hasConcept C55493867 @default.
• W1976995262 hasConcept C57306754 @default.
• W1976995262 hasConcept C79879829 @default.
• W1976995262 hasConcept C86803240 @default.
• W1976995262 hasConcept C97029542 @default.
• W1976995262 hasConceptScore W1976995262C134018914 @default.
• W1976995262 hasConceptScore W1976995262C170493617 @default.
• W1976995262 hasConceptScore W1976995262C181199279 @default.
• W1976995262 hasConceptScore W1976995262C184235292 @default.
• W1976995262 hasConceptScore W1976995262C185592680 @default.
• W1976995262 hasConceptScore W1976995262C24998067 @default.
• W1976995262 hasConceptScore W1976995262C2777989768 @default.
• W1976995262 hasConceptScore W1976995262C2778597717 @default.
• W1976995262 hasConceptScore W1976995262C2778938600 @default.
• W1976995262 hasConceptScore W1976995262C2779719074 @default.
• W1976995262 hasConceptScore W1976995262C38485361 @default.
• W1976995262 hasConceptScore W1976995262C48349386 @default.
• W1976995262 hasConceptScore W1976995262C55493867 @default.
• W1976995262 hasConceptScore W1976995262C57306754 @default.
• W1976995262 hasConceptScore W1976995262C79879829 @default.
• W1976995262 hasConceptScore W1976995262C86803240 @default.

• next