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• W1977004554 endingPage "171" @default.
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• W1977004554 abstract "Schizophrenia may result from altered gene expression leading to abnormal neurodevelopment. In a search for genes with altered expression in schizophrenia, our previous work on human frontal cerebral cortex found the mRNA of Nogo, a myelin-associated protein which inhibits the outgrowth of neurites and nerve terminals, to be overexpressed in schizophrenia. Because those earlier results did not examine tissues for the separate Nogo A, B and C isoforms from age- and sex-matched individuals, we repeated the study for all three isoforms, using a new set of tissues from matched individuals, and using the more accurate method of quantitative real-time PCR (polymerase chain reaction). We found Nogo C to be overexpressed by 26% in the schizophrenia tissues, which is in accordance with our earlier results. The expression of Nogo B was statistically significantly reduced by 17% in the frontal cortices from individuals who had been diagnosed as having had severe depression. Furthermore, we show that there is a direct correlation between the expression of Nogo A and C and the presence of alleles with a CAA insert, irrespective of disease status. While upregulation of Nogo C expression may play a role in schizophrenia, altered Nogo B may contribute to the clinical condition of depression. Nogo A showed a statistically non-significant increase in expression in schizophrenia." @default.
• W1977004554 created "2016-06-24" @default.
• W1977004554 creator A5004545899 @default.
• W1977004554 creator A5080835979 @default.
• W1977004554 date "2006-11-01" @default.
• W1977004554 modified "2023-09-24" @default.
• W1977004554 title "Nogo A, B and C expression in schizophrenia, depression and bipolar frontal cortex, and correlation of Nogo expression with CAA/TATC polymorphism in 3′-UTR" @default.
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• W1977004554 doi "https://doi.org/10.1016/j.brainres.2006.08.071" @default.
• W1977004554 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17022955" @default.
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