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- W1977010108 abstract "Hemorrhage and its deleterious effects on end-organ function are the leading causes of mortality and morbidity during warfare. We evaluated the effects of left ventricular assist device (LVAD) implantation on endorgan function and survival in a fixed-pressure bovine model of hemor-rhagic shock. Hemorrhage was induced in 8 calves to a mean arterial pressure of 40 mmHg which was then maintained for 30 min to simulate battlefield response time. Calves were resuscitated by administering 2 mL of Ringer's lactate for every 1 mL of blood lost. Four calves (Group 1) had an LVAD implanted after volume resuscitation. The remaining 4 calves (Group 2) underwent volume resuscitation only. All calves were monitored for and sacrificed at term (24 h). At 6 h post-hemorrhage, both groups had comparable hemoglobin levels (8.2±2.2 g/dL in Group 1 vs. 7.7±0.2 g/dL in Group 2, P=0.51) but differed in terms of plasma lactate (14.9±3.9 mmol/L in Group 1 vs. 50.5±23.3 mmol/L in Group 2, P=0.02), BUN (17.5±6.8 mg/dL in Group 1 vs. 37.5±3.5 mg/dL in Group 2, P=0.02), and creatinine (1.4±0.5 mg/dL in Group 1 vs. 2.4±0.1 mg/dL in Group 2, P=0.04). Mean survival was significantly longer in Group 1 than in Group 2 (22.75±2.5 h [range, 19–24 h] vs. 9.75±9.76 h [range, 2–24 h]) P<0.04). Within 6 h of hemorrhage, cardiac output increased significantly in Group 1 (4.4±1.6 L/min at baseline (pre-hemorrhage) vs. 8.5±1.6 L/min at 6 h, P<0.03) but remained unchanged in Group 2 (4.9±1.3 l/min at baseline vs. 5.4±1.2 L/min at 6 h, P=0.64). LVAD implantation improves survival and endorgan perfusion in a bovine model of hemorrhagic shock." @default.
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- W1977010108 date "2003-03-01" @default.
- W1977010108 modified "2023-10-18" @default.
- W1977010108 title "TREATMENT OF HEMORRHAGIC SHOCK WITH A LVAD" @default.
- W1977010108 doi "https://doi.org/10.1097/00002480-200303000-00106" @default.
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