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- W1977014717 abstract "Hop extract is a long used medicinal product and, regarding hormonal activities, in 1999 a number of prenylflavanones have been identified as its major constituents with 8-prenylnaringenin (8-PN) being the main active estrogenic compound. There have been several <i>in vivo</i> studies performed that demonstrate the potential of hop extract and the single compound 8-PN to alleviate climacteric symptoms like osteoporosis, vasomotoric complaints, and sexual motivation. On the other hand, only a few clinical studies have been performed so far, and these mainly focused on menopausal discomforts, especially hot flushes, yielding rather inconclusive results. Despite preferentially activating estrogen receptor <i>α</i>, 8-PN is only slightly uterotrophic, but it also elucidates estrogenic effects on the mammary gland. In conclusion, although hop extract and especially 8-PN are promising candidates as a relief for climacteric symptoms, data on the safety and efficacy is still scarce." @default.
- W1977014717 created "2016-06-24" @default.
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- W1977014717 date "2013-03-19" @default.
- W1977014717 modified "2023-09-25" @default.
- W1977014717 title "Hop Extracts and Hop Substances in Treatment of Menopausal Complaints" @default.
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- W1977014717 doi "https://doi.org/10.1055/s-0032-1328330" @default.
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