FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1977015903> ?p ?o ?g. }

• W1977015903 endingPage "1998" @default.
• W1977015903 startingPage "1997" @default.
• W1977015903 abstract "Ravinder Dhallan and colleagues1Dhallan R Guo X Emche S et al.A non-invasive test for prenatal diagnosis based on fetal DNA present in maternal blood: a preliminary study.Lancet. 2007; 369: 474-481Summary Full Text Full Text PDF PubMed Scopus (110) Google Scholar allude to the possible non-invasive detection of fetal aneuploidies by the quantitative analysis of paternally inherited single-nucleotide polymorphisms (SNPs) in cell-free fetal DNA. Although very high degrees of specificity were claimed, only two out of three cases with trisomy 21 were detected. Therefore this approach is no improvement over current screening strategies that use combinations of ultrasound and serum analytes. It is also inferior to that attained in a report in which cell-free fetal mRNA was used.2Lo YM Tsui NB Chiu RW et al.Plasma placental RNA allelic ratio permits noninvasive prenatal chromosomal aneuploidy detection.Nat Med. 2007; 13: 218-223Crossref PubMed Scopus (319) Google Scholar For this approach to be accepted in clinical practice, it will need to be verified independently, preferably in large multicentre studies. There are, however, several issues which will make an independent assessment difficult. These include the selection of candidate SNP loci, which is described in a patent not readily available to the research community. Additionally, how a quantitative procedure relying on numerous steps (preamplification, PCR, biotin-mediated capture, fluorescent labelling, electrophoresis, and digital imaging) can permit results involving 4 decimal places is unclear. Finally, this study relies on a former report wherein the authors suggested that the use of formaldehyde would increase the proportion of cell-free fetal DNA in maternal blood samples3Dhallan R Au WC Mattagajasingh S et al.Methods to increase the percentage of free fetal DNA recovered from the maternal circulation.JAMA. 2004; 291: 1114-1119Crossref PubMed Scopus (119) Google Scholar—a feature which could not be reproduced in several independent studies.4Chinnapapagari SK Holzgreve W Lapaire O Zimmermann B Hahn S Treatment of maternal blood samples with formaldehyde does not alter the proportion of circulatory fetal nucleic acids (DNA and mRNA) in maternal plasma.Clin Chem. 2005; 51: 652-655Crossref PubMed Scopus (43) Google Scholar, 5Chung GT Chiu RW Chan KC Lau TK Leung TN Lo YM Lack of dramatic enrichment of fetal DNA in maternal plasma by formaldehyde treatment.Clin Chem. 2005; 51: 655-658Crossref PubMed Scopus (48) Google Scholar Hence this report in its current form could be too preliminary. The research activities of the Laboratory for Prenatal Medicine and Gynaecological Oncology at the Basel University Women's Hospital Department of Research are funded by the EU (SH is the scientific director of the FP6 SAFE network) and the Swiss National Science Foundation. Additionally, a research agreement involving a patent transfer for the “non-invasive detection of fetal genetic traits” has been signed with Sequenom Inc, USA. Non-invasive prenatal diagnosis of Down's syndrome – Authors' replyIn researching methods to increase the proportion of fetal DNA recovered from maternal blood, and developing non-invasive methods for prenatal diagnosis, the main objective should be to contribute practical solutions to real-world problems. Full-Text PDF" @default.
• W1977015903 created "2016-06-24" @default.
• W1977015903 creator A5021044213 @default.
• W1977015903 creator A5046857211 @default.
• W1977015903 creator A5079617677 @default.
• W1977015903 date "2007-06-01" @default.
• W1977015903 modified "2023-10-16" @default.
• W1977015903 title "Non-invasive prenatal diagnosis of Down's syndrome" @default.
• W1977015903 cites W2038777713 @default.
• W1977015903 cites W2043686152 @default.
• W1977015903 cites W2083027033 @default.
• W1977015903 cites W2109338675 @default.
• W1977015903 cites W2128727320 @default.
• W1977015903 doi "https://doi.org/10.1016/s0140-6736(07)60936-2" @default.
• W1977015903 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17574085" @default.
• W1977015903 hasPublicationYear "2007" @default.
• W1977015903 type Work @default.
• W1977015903 sameAs 1977015903 @default.
• W1977015903 citedByCount "6" @default.
• W1977015903 countsByYear W19770159032014 @default.
• W1977015903 countsByYear W19770159032020 @default.
• W1977015903 crossrefType "journal-article" @default.
• W1977015903 hasAuthorship W1977015903A5021044213 @default.
• W1977015903 hasAuthorship W1977015903A5046857211 @default.
• W1977015903 hasAuthorship W1977015903A5079617677 @default.
• W1977015903 hasBestOaLocation W19770159031 @default.
• W1977015903 hasConcept C104317684 @default.
• W1977015903 hasConcept C142724271 @default.
• W1977015903 hasConcept C152110520 @default.
• W1977015903 hasConcept C153911025 @default.
• W1977015903 hasConcept C172680121 @default.
• W1977015903 hasConcept C2776229224 @default.
• W1977015903 hasConcept C2777445551 @default.
• W1977015903 hasConcept C2778258057 @default.
• W1977015903 hasConcept C2779234561 @default.
• W1977015903 hasConcept C2779672484 @default.
• W1977015903 hasConcept C30481170 @default.
• W1977015903 hasConcept C54355233 @default.
• W1977015903 hasConcept C60644358 @default.
• W1977015903 hasConcept C70721500 @default.
• W1977015903 hasConcept C71924100 @default.
• W1977015903 hasConcept C86803240 @default.
• W1977015903 hasConceptScore W1977015903C104317684 @default.
• W1977015903 hasConceptScore W1977015903C142724271 @default.
• W1977015903 hasConceptScore W1977015903C152110520 @default.
• W1977015903 hasConceptScore W1977015903C153911025 @default.
• W1977015903 hasConceptScore W1977015903C172680121 @default.
• W1977015903 hasConceptScore W1977015903C2776229224 @default.
• W1977015903 hasConceptScore W1977015903C2777445551 @default.
• W1977015903 hasConceptScore W1977015903C2778258057 @default.
• W1977015903 hasConceptScore W1977015903C2779234561 @default.
• W1977015903 hasConceptScore W1977015903C2779672484 @default.
• W1977015903 hasConceptScore W1977015903C30481170 @default.
• W1977015903 hasConceptScore W1977015903C54355233 @default.
• W1977015903 hasConceptScore W1977015903C60644358 @default.
• W1977015903 hasConceptScore W1977015903C70721500 @default.
• W1977015903 hasConceptScore W1977015903C71924100 @default.
• W1977015903 hasConceptScore W1977015903C86803240 @default.
• W1977015903 hasIssue "9578" @default.
• W1977015903 hasLocation W19770159031 @default.
• W1977015903 hasLocation W19770159032 @default.
• W1977015903 hasOpenAccess W1977015903 @default.
• W1977015903 hasPrimaryLocation W19770159031 @default.
• W1977015903 hasRelatedWork W1977509624 @default.
• W1977015903 hasRelatedWork W2035803341 @default.
• W1977015903 hasRelatedWork W2326096981 @default.
• W1977015903 hasRelatedWork W2343579303 @default.
• W1977015903 hasRelatedWork W2371048051 @default.
• W1977015903 hasRelatedWork W2793312892 @default.
• W1977015903 hasRelatedWork W2924110259 @default.
• W1977015903 hasRelatedWork W3028925543 @default.
• W1977015903 hasRelatedWork W3038047282 @default.
• W1977015903 hasRelatedWork W4384282879 @default.
• W1977015903 hasVolume "369" @default.
• W1977015903 isParatext "false" @default.
• W1977015903 isRetracted "false" @default.
• W1977015903 magId "1977015903" @default.
• W1977015903 workType "article" @default.