FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1977016976> ?p ?o ?g. }

• W1977016976 endingPage "722" @default.
• W1977016976 startingPage "715" @default.
• W1977016976 abstract "The effect of p-nitrophenyl-beta-D-xylopyranoside on glomerular extracellular matrices (glomerular basement membrane and mesangial matrix) proteoglycans was studied. The proteoglycans of rat kidneys were labeled with [35S]sulfate in the presence or absence of beta-xyloside (2.5 mM) by using an isolated organ perfusion system. The proteoglycans from the glomeruli and perfusion medium were isolated and characterized by Sepharose CL-6B chromatography and by their behavior in CsCl density gradients. With xyloside treatment there was a twofold decrease in 35S-labeled macromolecules in the tissues but a twofold increase in those recovered in the medium as compared with the control. The labeled proteoglycans extracted from control kidneys eluted as a single peak with Kav = 0.25 (Mr = approximately 130,000), and approximately 95% of the radioactivity was associated with heparan sulfate proteoglycan (HS-PG), the remainder with chondroitin (or dermatan) sulfate proteoglycan (CS-PG). In the xyloside-treated kidneys, the proteoglycans extracted from the tissue eluted as two peaks, Kav = 0.25 (Mr = approximately 130,000) and 0.41 (Mr = approximately 46,000), which contained approximately 40 and approximately 60% of the total radioactivity, respectively. The first peak contained mostly the HS-PG (approximately 90%) while the second peak had a mixture of HS-PG (approximately 70%) and CS-PG (approximately 30%). In controls, approximately 90% of the radioactivity, mostly HS-PG, was confined to high density fractions of a CsCl density gradient. In contrast, in xyloside experiments, both HS-PG and CS-PG were distributed in variable proportions throughout the gradient. The incorporated 35S activity in the medium of xyloside-treated kidneys was twice that of the controls and had three to four times the amount of free chondroitin (or dermatan) sulfate glycosaminoglycan chains. The data suggest that beta-xyloside inhibits the addition of de novo synthesized glycosaminoglycan chains onto the core protein of proteoglycans and at the same time stimulates the synthesis of chondroitin or dermatan sulfate chains which are mainly discharged into the perfusion medium." @default.
• W1977016976 created "2016-06-24" @default.
• W1977016976 creator A5024912124 @default.
• W1977016976 creator A5032471667 @default.
• W1977016976 creator A5055907298 @default.
• W1977016976 creator A5074468285 @default.
• W1977016976 date "1984-08-01" @default.
• W1977016976 modified "2023-10-15" @default.
• W1977016976 title "Effect of beta-D-xyloside on the glomerular proteoglycans. I. Biochemical studies." @default.
• W1977016976 cites W1482945758 @default.
• W1977016976 cites W1495143544 @default.
• W1977016976 cites W1499403515 @default.
• W1977016976 cites W1520513696 @default.
• W1977016976 cites W1529402584 @default.
• W1977016976 cites W1532868691 @default.
• W1977016976 cites W1539463185 @default.
• W1977016976 cites W1549492646 @default.
• W1977016976 cites W1590922852 @default.
• W1977016976 cites W1598470014 @default.
• W1977016976 cites W1599892620 @default.
• W1977016976 cites W1652854341 @default.
• W1977016976 cites W1775749144 @default.
• W1977016976 cites W1973371244 @default.
• W1977016976 cites W1980741458 @default.
• W1977016976 cites W1987760446 @default.
• W1977016976 cites W1998741154 @default.
• W1977016976 cites W2003818367 @default.
• W1977016976 cites W2006741091 @default.
• W1977016976 cites W2014856172 @default.
• W1977016976 cites W2021169580 @default.
• W1977016976 cites W2021937321 @default.
• W1977016976 cites W2039689033 @default.
• W1977016976 cites W2058124482 @default.
• W1977016976 cites W206526553 @default.
• W1977016976 cites W2066866422 @default.
• W1977016976 cites W2067422836 @default.
• W1977016976 cites W2074108958 @default.
• W1977016976 cites W2074946617 @default.
• W1977016976 cites W2077299968 @default.
• W1977016976 cites W2077400092 @default.
• W1977016976 cites W2081173855 @default.
• W1977016976 cites W2081189780 @default.
• W1977016976 cites W2129084058 @default.
• W1977016976 cites W2138258437 @default.
• W1977016976 cites W2323835621 @default.
• W1977016976 cites W2345513599 @default.
• W1977016976 cites W2402696601 @default.
• W1977016976 cites W2405130845 @default.
• W1977016976 cites W2406262512 @default.
• W1977016976 cites W2409671498 @default.
• W1977016976 cites W2438306795 @default.
• W1977016976 doi "https://doi.org/10.1083/jcb.99.2.715" @default.
• W1977016976 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2113256" @default.
• W1977016976 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/6746744" @default.
• W1977016976 hasPublicationYear "1984" @default.
• W1977016976 type Work @default.
• W1977016976 sameAs 1977016976 @default.
• W1977016976 citedByCount "41" @default.
• W1977016976 countsByYear W19770169762015 @default.
• W1977016976 countsByYear W19770169762019 @default.
• W1977016976 countsByYear W19770169762021 @default.
• W1977016976 crossrefType "journal-article" @default.
• W1977016976 hasAuthorship W1977016976A5024912124 @default.
• W1977016976 hasAuthorship W1977016976A5032471667 @default.
• W1977016976 hasAuthorship W1977016976A5055907298 @default.
• W1977016976 hasAuthorship W1977016976A5074468285 @default.
• W1977016976 hasBestOaLocation W19770169761 @default.
• W1977016976 hasConcept C153074725 @default.
• W1977016976 hasConcept C181199279 @default.
• W1977016976 hasConcept C185592680 @default.
• W1977016976 hasConcept C189165786 @default.
• W1977016976 hasConcept C2776735749 @default.
• W1977016976 hasConcept C2778066728 @default.
• W1977016976 hasConcept C2779335624 @default.
• W1977016976 hasConcept C2779553658 @default.
• W1977016976 hasConcept C2779881004 @default.
• W1977016976 hasConcept C43617362 @default.
• W1977016976 hasConcept C55493867 @default.
• W1977016976 hasConcept C86803240 @default.
• W1977016976 hasConceptScore W1977016976C153074725 @default.
• W1977016976 hasConceptScore W1977016976C181199279 @default.
• W1977016976 hasConceptScore W1977016976C185592680 @default.
• W1977016976 hasConceptScore W1977016976C189165786 @default.
• W1977016976 hasConceptScore W1977016976C2776735749 @default.
• W1977016976 hasConceptScore W1977016976C2778066728 @default.
• W1977016976 hasConceptScore W1977016976C2779335624 @default.
• W1977016976 hasConceptScore W1977016976C2779553658 @default.
• W1977016976 hasConceptScore W1977016976C2779881004 @default.
• W1977016976 hasConceptScore W1977016976C43617362 @default.
• W1977016976 hasConceptScore W1977016976C55493867 @default.
• W1977016976 hasConceptScore W1977016976C86803240 @default.
• W1977016976 hasIssue "2" @default.
• W1977016976 hasLocation W19770169761 @default.
• W1977016976 hasLocation W19770169762 @default.
• W1977016976 hasLocation W19770169763 @default.
• W1977016976 hasLocation W19770169764 @default.
• W1977016976 hasOpenAccess W1977016976 @default.
• W1977016976 hasPrimaryLocation W19770169761 @default.

• next