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• W1977019010 abstract "A series of fatty acids (i.e., lauric, myristic, palmitic and stearic acid) decreased the release of piroxicam from FAPG (fatty alcohol-propylene glycol) base. The reason was due to an increase in lipophilicity of the base. The released piroxicam was found to be inversely proportional to the apparent viscosity of the ointments containing a fatty acid. However, these fatty acids enhanced the in vitro skin permeation of piroxicam. Lauric acid and myristic acid also promoted in vivo percutaneous absorption in rats. A small decrease in the release rate and high skin permeation compared to the control FAPG base (no fatty acid) were important in order to gain appreciable in vivo percutaneous absorption. The effect of fatty acid on the in vivo percutaneous absorption of piroxicam from the FAPG base can be estimated by comparing the in vitro rate of drug released from the base and the in vitro rate of drug absorption by the treated skin with those of containing no fatty acid." @default.
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• W1977019010 date "1994-05-01" @default.
• W1977019010 modified "2023-09-26" @default.
• W1977019010 title "Percutaneous absorption of piroxicam from FAPG base through rat skin: effects of fatty acid added to FAPG base" @default.
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• W1977019010 doi "https://doi.org/10.1016/0378-5173(94)90269-0" @default.
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