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• W1977025906 abstract "Abstract Nevus anemicus ( NA ) is a cutaneous anomaly characterized by pale, well‐defined patches with limited vascularization after rubbing. They are largely known to be associated with neurofibromatosis 1 ( NF 1) and have received little attention in the literature until recently. We sought to characterize the prevalence and clinical features of patients with NA and NF 1. We conducted an observational prospective study of 99 children with NF 1 at the Hospital Niño Jesús, Madrid, Spain, from January 1, 2012, through July 31, 2013, and reviewed three other series of patients with NF 1 and NA recently reported. The prevalence of NA in children with NF 1 ranged from 8.8% to 51%, being much more prevalent at younger ages. Prospective studies yielded a higher prevalence than retrospective studies. NA was located most commonly on the trunk, particularly on the anterior chest wall, and was often multiple. Patients with segmental NF 1 or isolated café au lait spots rarely had NA , and NA was absent in other genodermatoses. The collection of data was not homogeneous in all studies. NA has a high prevalence in individuals with NF 1 patients but seems to be absent in connection with other genodermatoses, therefore its presence can assist in the diagnosis of suspected cases of NF 1. The subtle clinical appearance of NA makes its detection difficult, and physicians involved in the care of children with NF 1 must be aware of its possible presence and significance." @default.
• W1977025906 created "2016-06-24" @default.
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• W1977025906 date "2015-02-18" @default.
• W1977025906 modified "2023-10-14" @default.
• W1977025906 title "Nevus Anemicus: A Distinctive Cutaneous Finding in Neurofibromatosis Type 1" @default.
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• W1977025906 doi "https://doi.org/10.1111/pde.12525" @default.
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